Tricyclic delta opioid modulators

ABSTRACT

The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims benefit to U.S. Provisional Application Ser. No.60/638,315, filed Dec. 22, 2004, incorporated herein by reference in itsentirety.

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

The research and development of the invention described below was notfederally sponsored.

BACKGROUND

The term “opiate” has been used to designate pharmacologically activealkaloids derived from opium, e.g., morphine, codeine, and manysemi-synthetic congeners of morphine. After the isolation of peptidecompounds with morphine-like actions, the term opioid was introduced torefer generically to all drugs with morphine-like actions. Includedamong opioids are various peptides that exhibit morphine-like activity,such as endorphins, enkephalins and dynorphins. However, some sourcesuse the term “opiate” in a generic sense, and in such contexts, opiateand opioid are interchangeable. Additionally, the term opioid has beenused to refer to antagonists of morphine-like drugs as well as tocharacterize receptors or binding sites that combine with such agents.

Opioids are generally employed as analgesics, but they may have manyother pharmacological effects as well. Morphine and related opioidsproduce certain of their major effects on the central nervous anddigestive systems. The effects are diverse, including analgesia,drowsiness, mood changes, respiratory depression, dizziness, mentalclouding, dysphoria, pruritus, increased pressure in the biliary tract,decreased gastrointestinal motility, nausea, vomiting, and alterationsof the endocrine and autonomic nervous systems.

When therapeutic doses of morphine are given to patients with pain, theyreport that the pain is less intense, less discomforting, or entirelygone. In addition to experiencing relief of distress, some patientsexperience euphoria. However, when morphine in a selected pain-relievingdose is given to a pain-free individual, the experience is not alwayspleasant; nausea is common, and vomiting may also occur. Drowsiness,inability to concentrate, difficulty in mentation, apathy, lessenedphysical activity, reduced visual acuity, and lethargy may ensue.

Two distinct classes of opioid molecules can bind opioid receptors: theopioid peptides (e.g., the enkephalins, dynorphins, and endorphins) andthe alkaloid opiates (e.g., morphine, etorphine, diprenorphine andnaloxone). Subsequent to the initial demonstration of opiate bindingsites (Pert, C. B. and Snyder, S. H., Science (1973) 179:1011-1014), thedifferential pharmacological and physiological effects of both opioidpeptide analogues and alkaloid opiates served to delineate multipleopioid receptors. Accordingly, three molecularly and pharmacologicallydistinct opioid receptor types have been described: delta, kappa and mu.Furthermore, each type is believed to have sub-types (Wollemann, M., JNeurochem (1990) 54:1095-1101; Lord, J. A., et al., Nature (1977)267:495-499).

All three of these opioid receptor types appear to share the samefunctional mechanisms at a cellular level. For example, the opioidreceptors cause inhibition of adenylate cyclase, and inhibition ofneurotransmitter release via both potassium channel activation andinhibition of Ca²⁺ channels (Evans, C. J., In: Biological Basis ofSubstance Abuse, S. G. Korenman & J. D. Barchas, eds., Oxford UniversityPress (in press); North, A. R., et al., Proc Natl Acad Sci USA (1990)87:7025-29; Gross, R. A., et al., Proc Natl Acad Sci USA (1990)87:7025-29; Sharma, S. K., et al., Proc Natl Acad Sci USA (1975)72:3092-96). Although the functional mechanisms are the same, thebehavioral manifestations of receptor-selective drugs differ greatly(Gilbert, P. E. & Martin, W. R., J Pharmacol Exp Ther (1976) 198:66-82).Such differences may be attributable in part to the anatomical locationof the different receptors.

Delta receptors have a more discrete distribution within the mammalianCNS than either mu or kappa receptors, with high concentrations in theamygdaloid complex, striatum, substantia nigra, olfactory bulb,olfactory tubercles, hippocampal formation, and the cerebral cortex(Mansour, A., et al., Trends in Neurosci (1988) 11:308-14). The ratcerebellum is remarkably devoid of opioid receptors including deltaopioid receptors.

D. Delorme, E. Roberts and Z. Wei, World Patent WO/28275 (1998)discloses diaryl methylidenylpiperidines that are opioid analgesics, butdoes not disclose or suggest the compounds of the present invention.

C. Kaiser, and others (J. Med. Chem. 1974, Volume 17, pages 57-61)disclose some piperidylidene derivatives of thioxanthenes, xanthenes,dibenoxepins and acridans that are neuroleptic agents. These authors,however, do not disclose or suggest either the structure or the activityof the compounds of the present invention.

British Patent GB 1128734 (1966) discloses derivatives of6,11-dihydrodibenzo[b,e]oxepine that are anticholinergic,anti-convulsive, muscle-relaxing, sedating, diuretic, and/or vasoactiveagents. These, agents, however, differ significantly from the compoundsof the present invention both structurally and pharmacologically.

There is a continuing need for new delta opioid receptor modulators asanalgesics. There is a further need for delta opioid receptor selectiveagonists as analgesics having reduced side effects. There is also a needfor delta opioid receptor antagonists as immunosuppressants,antiinflammatory agents, agents for the treatment of neurological andpsychiatric conditions, agents for the treatment of urological andreproductive conditions, medicaments for drug and alcohol abuse, agentsfor treating gastritis and diarrhea, cardiovascular agents and agentsfor the treatment of respiratory diseases, having reduced side effects.

SUMMARY

The present invention is directed, inter alia, to compounds of Formula(I) and compositions comprising a compound of Formula (I):

wherein:

-   -   G is —C(Z)N(R₁)R₂, C₆₋₁₀aryl, or a heterocycle selected from the        group consisting of imidazolyl, triazolyl, tetrazolyl,        oxadiazolyl, thiadiazolyl, oxathiadiazolyl, imidazolinyl,        tetrahydropyrimidinyl, thienyl, pyrazolyl, pyrimidinyl,        triazinyl, furyl, indazolyl, indolyl, indolinyl, isothiazolyl,        isoxazolyl, oxazolyl, isoxadiazolyl, benzoxazolyl, quinolinyl,        isoquinolinyl, and pyridinyl; wherein aryl and the heterocycles        of G are optionally substituted with one to three substituents        independently selected from the group consisting of C₁₋₈alkanyl,        C₂₋₈alkenyl, C₂₋₈alkynyl, C₁₋₈alkanyloxy, hydroxy(C₁₋₈)alkanyl,        carboxy(C₁₋₈)alkanyl, C₁₋₈alkanylcarbonylamino, halogen,        hydroxy, cyano, nitro, oxo, thioxo, amino, C₁₋₆alkanylamino,        di(C₁₋₆alkanyl)amino, C₁₋₈alkanylthio, C₁₋₈alkanylsulfonyl,        C₁₋₈alkanylsulfonylamino, aminocarbonyl, aminothiocarbonyl,        aminocarbonylamino, aminothiocarbonylamino,        C₁₋₈alkanylaminocarbonyl, di(C₁₋₈alkanyl)aminocarbonyl, and        C₁₋₆alkanyloxycarbonylamino;    -   R₁ is a substituent selected from the group consisting of        hydrogen, C₁₋₈alkanyl, C₂₋₈alkenyl, and C₂₋₈alkynyl;    -   R₂ is a substituent selected from the group consisting of        hydrogen; C₁₋₈alkanyl; C₂₋₈alkenyl; C₂₋₈alkynyl; C₆₋₁₀aryl; and        C₁₋₈cycloalkanyl; wherein C₁₋₈alkanyl is optionally substituted        with one to three substituents independently selected from the        group consisting of phenyl, amino, C₁₋₆alkanylamino,        di(C₁₋₆alkanyl)amino, C₁₋₆alkanyloxy, thioC₁₋₆alkanyloxy,        hydroxy, fluoro, chloro, cyano, aminocarbonyl,        C₁₋₈alkanylaminocarbonyl, di(C₁₋₈alkanyl)aminocarbonyl,        C₁₋₆alkanyloxycarbonyl, and aryloxy; and wherein any        aryl-containing substituents and C₁₋₈cycloalkanyl substituents        of R₂ are optionally substituted with one to three substituents        independently selected from the group consisting of C₁₋₈alkanyl,        C₂₋₈alkenyl, C₂₋₈alkynyl, C₁₋₈alkanyloxy, trifluoromethyl,        trifluoromethoxy, phenyl, halogen, cyano, hydroxy,        C₁₋₈alkanylthio, C₁₋₈alkanylsulfonyl, and        C₁₋₈alkanylsulfonylamino;    -   or R₁ and R₂ taken together with the nitrogen to which they are        attached form a 5-7 membered cycloheteroalkyl optionally        substituted with one to three substituents independently        selected from the group consisting of C₁₋₈alkanyl,        hydroxy(C₁₋₈)alkanyl, hydroxy, amino, C₁₋₆alkanylamino,        di(C₁₋₆alkanyl)amino, and halogen;    -   R₃ is a substituent selected from the group consisting of        hydrogen, C₁₋₈alkanyl, halo₁₋₃(C₁₋₈)alkanyl, C₂₋₈alkenyl,        C₂₋₈alkynyl, C₃₋₈cycloalkanyl, cycloalkanyl(C₁₋₈)alkanyl,        C₁₋₈alkanyloxy(C₁₋₈)alkanyl, C₁₋₈alkanylthio(C₁₋₈)alkanyl,        hydroxyC₁₋₈alkanyl, C₁₋₈alkanyloxycarbonyl,        halo₁₋₃(C₁₋₈)alkanylcarbonyl, formyl, thioformyl, carbamimidoyl,        phenylamino(C₁₋₈)alkanyl, phenyl(C₁₋₈)alkanyl,        phenyl(C₁₋₈)alkenyl, phenyl(C₁₋₈)alkynyl, naphthyl(C₁₋₈)alkanyl        and heteroaryl(C₁₋₈)alkanyl wherein the heteroaryl is selected        from the group consisting of benzo[1,3]dioxolyl, imidazolyl,        furanyl, pyridinyl, thienyl, indazolyl, indolyl, indolinyl,        isoindolinyl, isoquinolinyl, isothiazolyl, isoxazolyl, oxazolyl,        pyrazinyl, pyrazolyl, pyridazinyl, pyrimidinyl, pyrrolyl,        quinolinyl, isoquinolinyl, tetrazolyl, thiazolyl; wherein        phenyl, naphthyl and heteroaryl are optionally substituted with        one to three substituents independently selected from the group        consisting of C₁₋₆alkanyl, C₂₋₆alkenyl, C₁₋₆alkanyloxy, amino,        C₁₋₆alkanylamino, di(C₁₋₆alkanyl)amino, C₁₋₆alkanylcarbonyl,        C₁₋₆alkanylcarbonyloxy, C₁₋₆alkanylcarbonylamino,        C₁₋₆alkanylthio, C₁₋₆alkanylsulfonyl, halogen, hydroxy, cyano,        fluoro(C₁₋₆)alkanyl, thioureido, and fluoro(C₁₋₆)alkanyloxy;        alternatively, when phenyl and heteroaryl are optionally        substituted with alkanyl or alkanyloxy substituents attached to        adjacent carbon atoms, the two substituents can together form a        fused cyclic alkanyl or cycloheteroalkanyl selected from the        group consisting of —(CH₂)₃₋₅—, —O(CH₂)₂₋₄—, —(CH₂)₂₋₄O—, and        —O(CH₂)₁₋₃O—;    -   R₄ is one to three substituents independently selected from the        group consisting of hydrogen; C₁₋₆alkanyl; C₂₋₆alkenyl;        C₂₋₆alkynyl; aryl(C₂₋₆)alkynyl; C₁₋₆alkanyloxy; amino;        C₁₋₆alkanylamino; di(C₁₋₆alkanyl)amino; C₆₋₁₀arylamino wherein        C₆₋₁₀aryl is optionally substituted with one to three        substituents independently selected from the group consisting of        C₁₋₆alkanyl, C₁₋₆alkoxy, halogen, and hydroxyl; formylamino;        pyridinylamino; C₁₋₆alkanylcarbonyl; C₁₋₆alkanylcarbonyloxy;        C₁₋₆alkanyloxycarbonyl; aminocarbonyl; C₁₋₆alkanylaminocarbonyl;        di(C₁₋₆alkanyl)aminocarbonyl; C₁₋₆alkanylcarbonylamino;        C₁₋₆alkanylthio; C₁₋₆alkanylsulfonyl; halogen; hydroxy; cyano;        hydroxycarbonyl; C₆₋₁₀aryl; chromanyl; chromenyl; furanyl;        imidazolyl; indazolyl; indolyl; indolinyl; isoindolinyl;        isoquinolinyl; isothiazolyl; isoxazolyl; naphthyridinyl;        oxazolyl; pyrazinyl; pyrazolyl; pyridazinyl; pyridinyl;        pyrimidinyl; pyrrolyl; quinazolinyl; quinolinyl; quinolizinyl;        quinoxalinyl; tetrazolyl; thiazolyl; thienyl; fluoroalkanyl and        fluoroalkanyloxy; or optionally, when R₄ is two substituents        attached to adjacent carbon atoms, the two substituents together        form a single fused moiety; wherein the fused moiety is        —(CH₂)₃₋₅—, —O(CH₂)₂₋₄—, —(CH₂)₂₋₄O—, —O(CH₂)₁₋₃O—, or        —S—C(NH₂)═N—;    -   R₅ is one to two substituents independently selected from the        group consisting of hydrogen, C₁₋₆alkanyl, C₂₋₆alkenyl,        C₁₋₆alkanyloxy, amino, C₁₋₆alkanylamino, di(C₁₋₆alkanyl)amino,        C₁₋₆alkanylcarbonyl, C₁₋₆alkanylcarbonyloxy,        C₁₋₆alkanyloxycarbonyl, C₁₋₆alkanylaminocarbonyl,        C₁₋₆alkanylcarbonylamino, C₁₋₆alkanylthio, C₁₋₆alkanylsulfonyl,        halogen, hydroxy, cyano, fluoro(C₁₋₆)alkanyl and        fluoro(C₁₋₆)alkanyloxy;    -   A is —(CH₂)_(m)—, wherein m is 2 or 3;    -   Y is O or S;    -   Z is O, S, NH, N(C₁₋₆alkanyl), N(OH), N(OC₁₋₆alkanyl), or        N(phenyl);        and enantiomers, diastereomers, tautomers, solvates, or        pharmaceutically acceptable salts thereof.

The present invention is also directed to, inter alia, veterinary andpharmaceutical compositions containing compounds of Formula (I) whereinthe compositions are used to treat mild to severe pain in warm-bloodedanimals.

DETAILED DESCRIPTION

As used herein, the following underlined terms are intended to have thefollowing meanings:

“C_(a-b)” (where a and b are integers) refers to a radical containingfrom a to b carbon atoms inclusive. For example, C₁₋₃ denotes a radicalcontaining 1, 2 or 3 carbon atoms

“Alkyl:” refers to a saturated or unsaturated, branched, straight-chainor cyclic monovalent hydrocarbon radical derived by the removal of onehydrogen atom from a single carbon atom of a parent alkane, alkene oralkyne. Typical alkyl groups include, but are not limited to, methyl;ethyls such as ethanyl, ethenyl, ethynyl; propyls such as propan-1-yl,propan-2-yl , cyclopropan-1-yl, prop-1-en-1-yl, prop-1-en-2-yl,prop-2-en-1-yl, cycloprop-1-en-1-yl; cycloprop-2-en-1-yl,prop-1-yn-1-yl, prop-2-yn-1-yl, etc.; butyls such as butan-1-yl,butan-2-yl, 2-methyl-propan-1-yl, 2-methyl-propan-2-yl, cyclobutan-1-yl,but-1-en-1-yl, but-1-en-2-yl, 2-methyl-prop-1-en-1-yl, but-2-en-1-yl,but-2-en-2-yl, buta-1,3-dien-1-yl, buta-1,3-dien-2-yl,cyclobut-1-en-1-yl, cyclobut-1-en-3-yl, cyclobuta-1,3-dien-1-yl,but-1-yn-1-yl, but-1-yn-3-yl, but-3-yn-1-yl, etc.; and the like. Wherespecific levels of saturation are intended, the nomenclature “alkanyl”,“alkenyl” and/or “alkynyl” is used, as defined below. In preferredembodiments, the alkyl groups are (C₁-C₆) alkyl, with (C₁-C₃) beingparticularly preferred.

“Alkanyl:” refers to a saturated branched, straight-chain or cyclicmonovalent hydrocarbon radical derived by the removal of one hydrogenatom from a single carbon atom of a parent alkane. Typical alkanylgroups include, but are not limited to, methanyl; ethanyl; propanylssuch as propan-1-yl, propan-2-yl, cyclopropan-1-yl, etc.; butyanyls suchas butan-1-yl, butan-2-yl, 2-methyl-propan-1-yl, 2-methyl-propan-2-yl,cyclobutan-1-yl, etc.; and the like. In preferred embodiments, thealkanyl groups are (C₁₋₈) alkanyl, with (C₁₋₃) being particularlypreferred.

“Alkenyl” refers to an unsaturated branched, straight-chain or cyclicmonovalent hydrocarbon radical having at least one carbon-carbon doublebond derived by the removal of one hydrogen atom from a single carbonatom of a parent alkene. The radical may be in either the cis or transconformation about the double bond(s). Typical alkenyl groups include,but are not limited to, ethenyl; propenyls such as prop-1-en-1-yl,prop-1-en-2-yl, prop-2-en-1-yl, prop-2-en-2-yl, cycloprop-1-en-1-yl;cycloprop-2-en-1-yl; butenyls such as but-1-en-1-yl, but-1-en-2-yl,2-methyl-prop-1-en-1-yl, but-2-en-1-yl, but-2-en-1-yl, but-2-en-2-yl,buta-1,3-dien-1-yl, buta-1,3-dien-2-yl, cyclobut-1-en-1-yl,cyclobut-1-en-3-yl, cyclobuta-1,3-dien-1-yl, etc.; and the like.

“Alkynyl” refers to an unsaturated branched, straight-chain or cyclicmonovalent hydrocarbon radical having at least one carbon-carbon triplebond derived by the removal of one hydrogen atom from a single carbonatom of a parent alkyne. Typical alkynyl groups include, but are notlimited to, ethynyl; propynyls such as prop-1-yn-1-yl, prop-2-yn-1-yl,etc.; butynyls such as but-1-yn-1-yl, but-1-yn-3-yl, but-3-yn-1-yl,etc.; and the like.

“Heteroalkyl” and Heteroalkanyl” refer to alkyl or alkanyl radicals,respectively, in which one or more carbon atoms (and any necessaryassociated hydrogen atoms) are independently replaced with the same ordifferent heteroatoms (including any necessary hydrogen or other atoms).Typical heteroatoms to replace the carbon atom(s) include, but are notlimited to, N, P, O, S, Si, etc. Preferred heteroatoms are O, N and S.Thus, heteroalkanyl radicals can contain one or more of the same ordifferent heteroatomic groups, including, by way of example and notlimitation, epoxy (—O—), epidioxy (—O—O—), thioether (—S—), epidithio(—SS—), epoxythio (—O—S—), epoxyimino (—O—NR′—), imino (—NR′—), biimino(—NR′—NR′—), azino (═N—N═), azo (—N═N—), azoxy (—N—O—N—), azimino(—NR′—N═N—), phosphano (—PH—), λ⁴-sulfano (—SH₂—), sulfonyl (—S(O)₂—),and the like, where each R′ is independently hydrogen or (C₁-C₆) alkyl.

“Parent Aromatic Ring System:” refers to an unsaturated cyclic orpolycyclic ring system having a conjugated π electron system.Specifically included within the definition of “parent aromatic ringsystem” are fused ring systems in which one or more rings are aromaticand one or more rings are saturated or unsaturated, such as, forexample, indane, indene, phenalene, etc. Typical parent aromatic ringsystems include, but are not limited to, aceanthrylene, acenaphthylene,acephenanthrylene, anthracene, azulene, benzene, chrysene, coronene,fluoranthene, fluorene, hexacene, hexaphene, hexalene, as-indacene,s-indacene, indane, indene, naphthalene, octacene, octaphene, octalene,ovalene, penta-2,4-diene, pentacene, pentalene, pentaphene, perylene,phenalene, phenanthrene, picene, pleiadene, pyrene, pyranthrene,rubicene, triphenylene, trinaphthalene, and the like

“Aryl:” refers to a monovalent aromatic hydrocarbon radical derived bythe removal of one hydrogen atom from a single carbon atom of a parentaromatic ring system. Typical aryl groups include, but are not limitedto, radicals derived from aceanthrylene, acenaphthylene,acephenanthrylene, anthracene, azulene, benzene, chrysene, coronene,fluoranthene, fluorene, hexacene, hexaphene, hexalene, as-indacene,s-indacene, indane, indene, naphthalene, octacene, octaphene, octalene,ovalene, penta-2,4-diene, pentacene, pentalene, pentaphene, perylene,phenalene, phenanthrene, picene, pleiadene, pyrene, pyranthrene,rubicene, triphenylene, trinaphthalene, and the like. In preferredembodiments, the aryl group is (C₅₋₂₀) aryl, with (C₅₋₁₀) beingparticularly preferred. Particularly preferred aryl groups are phenyland naphthyl groups.

“Arylalkyl:” refers to an acyclic alkyl group in which one of thehydrogen atoms bonded to a carbon atom, typically a terminal carbonatom, is replaced with an aryl radical. Typical arylalkyl groupsinclude, but are not limited to, benzyl, 2-phenylethan-1-yl,2-phenylethen-1-yl, naphthylmethyl, 2-naphthylethan-1-yl,2-naphthylethen-1-yl, naphthobenzyl, 2-naphthophenylethan-1-yl and thelike. Where specific alkyl moieties are intended, the nomenclaturearylalkanyl, arylakenyl and/or arylalkynyl is used. [In preferredembodiments, the arylalkyl group is (C₆₋₂₆) arylalkyl, e.g., thealkanyl, alkenyl or alkynyl moiety of the arylalkyl group is (C₁₋₆) andthe aryl moiety is (C₅₋₂₀). In particularly preferred embodiments thearylalkyl group is (C₆₋₁₃), e.g., the alkanyl, alkenyl or alkynyl moietyof the arylalkyl group is (C₁₋₃) and the aryl moiety is (C₅₋₁₀). Evenmore preferred arylalkyl groups are phenylalkanyls.

“Alkanyloxy:” refers to a saturated branched, straight-chain or cyclicmonovalent hydrocarbon alcohol radical derived by the removal of thehydrogen atom from the hydroxide oxygen of the alcohol. Typicalalkanyloxy groups include, but are not limited to, methanyloxy;ethanyloxy; propanyloxy groups such as propan-1-yloxy (CH₃CH₂CH₂O—),propan-2-yloxy ((CH₃)₂CHO—), cyclopropan-1-yloxy, etc.; butanyloxygroups such as butan-1-yloxy, butan-2-yloxy, 2-methyl-propan-1-yloxy,2-methyl-propan-2-yloxy, cyclobutan-1-yloxy, etc.; and the like. Inpreferred embodiments, the alkanyloxy groups are (C₁₋₈) alkanyloxygroups, with (C₁₋₃) being particularly preferred.

“Parent Heteroaromatic Ring System:” refers to a parent aromatic ringsystem in which one carbon atom is replaced with a heteroatom.Heteroatoms to replace the carbon atoms include N, O, and S.Specifically included within the definition of “parent heteroaromaticring systems” are fused ring systems in which one or more rings arearomatic and one or more rings are saturated or unsaturated, such as,for example, arsindole, chromane, chromene, indole, indoline, xanthene,etc. Typical parent heteroaromatic ring systems include, but are notlimited to, carbazole, imidazole, indazole, indole, indoline,indolizine, isoindole, isoindoline, isoquinoline, isothiazole,isoxazole, naphthyridine, oxadiazole, oxazole, purine, pyran, pyrazine,pyrazole, pyridazine, pyridine, pyrimidine, pyrrole, pyrrolizine,quinazoline, quinoline, quinolizine, quinoxaline, tetrazole,thiadiazole, thiazole, thiophene, triazole, xanthene, and the like.

“Heteroaryl:” refers to a monovalent heteroaromatic radical derived bythe removal of one hydrogen atom from a single atom of a parentheteroaromatic ring system. Typical heteroaryl groups include, but arenot limited to, radicals derived from carbazole, imidazole, indazole,indole, indoline, indolizine, isoindole, isoindoline, isoquinoline,isothiazole, isoxazole, naphthyridine, oxadiazole, oxazole, purine,pyran, pyrazine, pyrazole, pyridazine, pyridine, pyrimidine, pyrrole,pyrrolizine, quinazoline, quinoline, quinolizine, quinoxaline,tetrazole, thiadiazole, thiazole, thiophene, triazole, xanthene, and thelike. In preferred embodiments, the heteroaryl group is a 5-20 memberedheteroaryl, with 5-10 membered heteroaryl being particularly preferred.

“Cycloheteroalkyl:” refers to a saturated or unsaturated monocyclic orbicyclic alkyl radical in which one carbon atom is replaced with N, O orS. In certain specified embodiments the cycloheteroalkyl may contain upto four heteroatoms independently selected from N, O or S. Typicalcycloheteroalkyl moieties include, but are not limited to, radicalsderived from imidazolidine, morpholine, piperazine, piperidine,pyrazolidine, pyrrolidine, quinuclidine, and the like. In preferredembodiments, the cycloheteroalkyl is a 3-6 membered cycloheteroalkyl.

“Cycloheteroalkanyl:” refers to a saturated monocyclic or bicyclicalkanyl radical in which one carbon atom is replaced with N, O or S. Incertain specified embodiments the cycloheteroalkanyl may contain up tofour heteroatoms independently selected from N, O or S. Typicalcycloheteroalkanyl moieties include, but are not limited to, radicalsderived from imidazolidine, morpholine, piperazine, piperidine,pyrazolidine, pyrrolidine, quinuclidine, and the like. In preferredembodiments, the cycloheteroalkanyl is a 3-6 memberedcycloheteroalkanyl.

“Cycloheteroalkenyl:” refers to a saturated monocyclic or bicyclicalkenyl radical in which one carbon atom is replaced with N, O or S. Incertain specified embodiments the cycloheteroalkenyl may contain up tofour heteroatoms independently selected from N, O or S. Typicalcycloheteroalkenyl moieties include, but are not limited to, radicalsderived from imidazoline, pyrazoline, pyrroline, indoline, pyran, andthe like. In preferred embodiments, the cycloheteroalkanyl is a 3-6membered cycloheteroalkanyl.

“Substituted:” refers to a radical in which one or more hydrogen atomsare each independently replaced with the same or differentsubstituent(s). Typical substituents include, but are not limited to,—X, —R, —O⁻, ═O, —OR, —O—OR, —SR, —S⁻, ═S, —NRR, ═NR, —CX₃, —CN, —OCN,—SCN, —NCO, —NCS, —NO, —NO₂, ═N₂, —N₃, —NHOH, —S(O)₂O⁻, —S(O)₂OH,—S(O)₂R, —P(O)(O⁻)₂, —P(O)(OH)₂, —C(O)R, —C(O)X, —C(S)R, —C(S)X,—C(O)OR, —C(O)O⁻, —C(S)OR, —C(O)SR, —C(S)SR, —C(O)NRR, —C(S)NRR and—C(NR)NRR, where each X is independently a halogen (preferably —F, —Clor —Br) and each R is independently —H, alkyl, alkanyl, alkenyl,alkynyl, alkylidene, alkylidyne, aryl, arylalkyl, arylheteroalkyl,heteroaryl, heteroarylalkyl or heteroaryl-heteroalkyl, as definedherein. Preferred substituents include hydroxy, halogen, C₁₋₈alkyl,C₁₋₈alkanyloxy, fluorinated alkanyloxy, fluorinated alkyl,C₁₋₈alkylthio, C₃₋₈cycloalkyl, C₃₋₈cycloalkanyloxy, nitro, amino,C₁₋₈alkylamino, C₁₋₈dialkylamino, C₃₋₈cycloalkylamino, cyano, carboxy,C₁₋₇alkanyloxycarbonyl, C₁₋₇alkylcarbonyloxy, formyl, carbamoyl, phenyl,aroyl, carbamoyl, amidino, (C₁₋₈alkylamino)carbonyl, (arylamino)carbonyland aryl(C₁₋₈alkyl)carbonyl.

With reference to substituents, the term “independently” means that whenmore than one of such substituent is possible, such substituents may bethe same or different from each other.

Throughout this disclosure, the terminal portion of the designated sidechain is described first, followed by the adjacent functionality towardthe point of attachment. Thus, for example, a“phenylC₁₋₆alkanylaminocarbonylC₁₋₆alkyl” substituent refers to a groupof the formula

The present invention is directed, inter alia, to compounds of Formula(I) and compositions comprising a compound of Formula (I):

wherein:

-   -   G is —C(Z)N(R₁)R₂, C₆₋₁₀aryl, or a heterocycle selected from the        group consisting of imidazolyl, triazolyl, tetrazolyl,        oxadiazolyl, thiadiazolyl, oxathiadiazolyl, imidazolinyl,        tetrahydropyrimidinyl, thienyl, pyrazolyl, pyrimidinyl,        triazinyl, furyl, indazolyl, indolyl, indolinyl, isothiazolyl,        isoxazolyl, oxazolyl, isoxadiazolyl, benzoxazolyl, quinolinyl,        isoquinolinyl, and pyridinyl; wherein aryl and the heterocycles        of G are optionally substituted with one to three substituents        independently selected from the group consisting of C₁₋₈alkanyl,        C₂₋₈alkenyl, C₂₋₈alkynyl, C₁₋₈alkanyloxy, hydroxy(C₁₋₈)alkanyl,        carboxy(C₁₋₈)alkanyl, C₁₋₈alkanylcarbonylamino, halogen,        hydroxy, cyano, nitro, oxo, thioxo, amino, C₁₋₆alkanylamino,        di(C₁₋₆alkanyl)amino, C₁₋₈alkanylthio, C₁₋₈alkanylsulfonyl,        C₁₋₈alkanylsulfonylamino, aminocarbonyl, aminothiocarbonyl,        aminocarbonylamino, aminothiocarbonylamino,        C₁₋₈alkanylaminocarbonyl, di(C₁₋₈alkanyl)aminocarbonyl, and        C₁₋₆alkanyloxycarbonylamino;    -   R₁ is a substituent selected from the group consisting of        hydrogen, C₁₋₈alkanyl, C₂₋₈alkenyl, and C₂₋₈alkynyl;    -   R₂ is a substituent selected from the group consisting of        hydrogen; C₁₋₈alkanyl; C₂₋₈alkenyl; C₂₋₈alkynyl; C₆₋₁₀aryl; and        C₁₋₈cycloalkanyl; wherein C₁₋₈alkanyl is optionally substituted        with one to three substituents independently selected from the        group consisting of phenyl, amino, C₁₋₆alkanylamino,        di(C₁₋₆alkanyl)amino, C₁₋₆alkanyloxy, thioC₁₋₆alkanyloxy,        hydroxy, fluoro, chloro, cyano, aminocarbonyl,        C₁₋₈alkanylaminocarbonyl, di(C₁₋₈alkanyl)aminocarbonyl,        C₁₋₆alkanyloxycarbonyl, and aryloxy; and wherein any        aryl-containing substituents and C₁₋₈cycloalkanyl substituents        of R₂ are optionally substituted with one to three substituents        independently selected from the group consisting of C₁₋₈alkanyl,        C₂₋₈alkenyl, C₂₋₈alkynyl, C₁₋₈alkanyloxy, trifluoromethyl,        trifluoromethoxy, phenyl, halogen, cyano, hydroxy,        C₁₋₈alkanylthio, C₁₋₈alkanylsulfonyl, and        C₁₋₈alkanylsulfonylamino;    -   or R₁ and R₂ taken together with the nitrogen to which they are        attached form a 5-7 membered cycloheteroalkyl optionally        substituted with one to three substituents independently        selected from the group consisting of C₁₋₈alkanyl,        hydroxy(C₁₋₈)alkanyl, hydroxy, amino, C₁₋₆alkanylamino,        di(C₁₋₆alkanyl)amino, and halogen;    -   R₃ is a substituent selected from the group consisting of        hydrogen, C₁₋₈alkanyl, halo₁₋₃(C₁₋₈)alkanyl, C₂₋₈alkenyl,        C₂₋₈alkynyl, C₃₋₈cycloalkanyl, cycloalkanyl(C₁₋₈)alkanyl,        C₁₋₈alkanyloxy(C₁₋₈)alkanyl, C₁₋₈alkanylthio(C₁₋₈)alkanyl,        hydroxyC₁₋₈alkanyl, C₁₋₈alkanyloxycarbonyl,        halo₁₋₃(C₁₋₈)alkanylcarbonyl, formyl, thioformyl, carbamimidoyl,        phenylimino(C₁₋₈)alkanyl, phenyl(C₁₋₈)alkanyl,        phenyl(C₁₋₈)alkenyl, phenyl(C₁₋₈)alkynyl, naphthyl(C₁₋₈)alkanyl        and heteroaryl(C₁₋₈)alkanyl wherein the heteroaryl is selected        from the group consisting of benzo[1,3]dioxolyl, imidazolyl,        furanyl, pyridinyl, thienyl, indazolyl, indolyl, indolinyl,        isoindolinyl, isoquinolinyl, isothiazolyl, isoxazolyl, oxazolyl,        pyrazinyl, pyrazolyl, pyridazinyl, pyrimidinyl, pyrrolyl,        quinolinyl, isoquinolinyl, tetrazolyl, thiazolyl; wherein        phenyl, naphthyl and heteroaryl are optionally substituted with        one to three substituents independently selected from the group        consisting of C₁₋₆alkanyl, C₂₋₆alkenyl, C₁₋₆alkanyloxy, amino,        C₁₋₆alkanylamino, di(C₁₋₆alkanyl)amino, C₁₋₆alkanylcarbonyl,        C₁₋₆alkanylcarbonyloxy, C₁₋₆alkanylcarbonylamino,        C₁₋₆alkanylthio, C₁₋₆alkanylsulfonyl, halogen, hydroxy, cyano,        fluoro(C₁₋₆)alkanyl, thioureido, and fluoro(C₁₋₆)alkanyloxy;        alternatively, when phenyl and heteroaryl are optionally        substituted with alkanyl or alkanyloxy substituents attached to        adjacent carbon atoms, the two substituents can together form a        fused cyclic alkanyl or cycloheteroalkanyl selected from the        group consisting of —(CH₂)₃₋₅—, —O(CH₂)₂₋₄—, —(CH₂)₂₋₄O—, and        —O(CH₂)₁₋₃O—;    -   R₄ is one to three substituents independently selected from the        group consisting of hydrogen; C₁₋₆alkanyl; C₂₋₆alkenyl;        C₂₋₆alkynyl; aryl(C₂₋₆)alkynyl; C₁₋₆alkanyloxy; amino;        C₁₋₆alkanylamino; di(C₁₋₆alkanyl)amino; C₆₋₁₀arylamino wherein        C₆₋₁₀aryl is optionally substituted with one to three        substituents independently selected from the group consisting of        C₁₋₆alkanyl, C₁₋₆alkoxy, halogen, and hydroxyl; formylamino;        pyridinylamino; C₁₋₆alkanylcarbonyl; C₁₋₆alkanylcarbonyloxy;        C₁₋₆alkanyloxycarbonyl; aminocarbonyl; C₁₋₆alkanylaminocarbonyl;        di(C₁₋₆alkanyl)aminocarbonyl; C₁₋₆alkanylcarbonylamino;        C₁₋₆alkanylthio; C₁₋₆alkanylsulfonyl; halogen; hydroxy; cyano;        hydroxycarbonyl; C₆₋₁₀aryl; chromanyl; chromenyl; furanyl;        imidazolyl; indazolyl; indolyl; indolinyl; isoindolinyl;        isoquinolinyl; isothiazolyl; isoxazolyl; naphthyridinyl;        oxazolyl; pyrazinyl; pyrazolyl; pyridazinyl; pyridinyl;        pyrimidinyl; pyrrolyl; quinazolinyl; quinolinyl; quinolizinyl;        quinoxalinyl; tetrazolyl; thiazolyl; thienyl; fluoroalkanyl and        fluoroalkanyloxy; or optionally, when R₄ is two substituents        attached to adjacent carbon atoms, the two substituents together        form a single fused moiety; wherein the fused moiety is        —(CH₂)₃₋₅—, —O(CH₂)₂₋₄—, —(CH₂)₂₋₄O—, —O(CH₂)₁₋₃O—, or        —S—C(NH₂)═N—;    -   R₅ is one to two substituents independently selected from the        group consisting of hydrogen, C₁₋₆alkanyl, C₂₋₆alkenyl,        C₁₋₆alkanyloxy, amino, C₁₋₆alkanylamino, di(C₁₋₆alkanyl)amino,        C₁₋₆alkanylcarbonyl, C₁₋₆alkanylcarbonyloxy,        C₁₋₆alkanyloxycarbonyl, C₁₋₆alkanylaminocarbonyl,        C₁₋₆alkanylcarbonylamino, C₁₋₆alkanylthio, C₁₋₆alkanylsulfonyl,        halogen, hydroxy, cyano, fluoro(C₁₋₆)alkanyl and        fluoro(C₁₋₆)alkanyloxy;    -   A is —(CH₂)_(m)—, wherein m is 2 or 3;    -   Y is O or S;    -   Z is O, S, NH, N(C₁₋₆alkanyl), N(OH), N(OC₁₋₆alkanyl), or        N(phenyl);        and enantiomers, diastereomers, tautomers, solvates, or        pharmaceutically acceptable salts thereof.

An embodiment of the present invention is directed to a compound ofFormula (I) wherein the structure is numbered as defined herein and thesubstituents are as defined herein.

The present invention is directed, inter alia, to analgesic andanti-pyretic uses of compositions comprising a compound of Formula (I):

wherein:

-   -   G is —C(Z)N(R₁)R₂, C₆₋₁₀aryl, or a heterocycle selected from the        group consisting of: imidazolyl, triazolyl, tetrazolyl,        oxadiazolyl, thiadiazolyl, oxathiadiazolyl, imidazolinyl,        tetrahydropyrimidinyl, thienyl, pyrazolyl, pyrimidinyl,        triazinyl, furyl, indazolyl, indolyl, indolinyl, isothiazolyl,        isoxazolyl, oxazolyl, isoxadiazolyl, benzoxazolyl, quinolinyl,        isoquinolinyl, and pyridinyl; wherein aryl and the heterocycles        of G are optionally substituted with one to three substituents        independently selected from the group consisting of C₁₋₈alkanyl,        C₂₋₈alkenyl, C₂₋₈alkynyl, C₁₋₈alkanyloxy, hydroxy(C₁₋₈)alkanyl,        carboxy(C₁₋₈)alkanyl, C₁₋₈alkanylcarbonylamino, halogen,        hydroxy, cyano, nitro, oxo, thioxo, amino, C₁₋₆alkanylamino,        di(C₁₋₆alkanyl)amino, C₁₋₈alkanylthio, C₁₋₈alkanylsulfonyl,        C₁₋₈alkanylsulfonylamino, aminocarbonyl, aminothiocarbonyl,        aminocarbonylamino, aminothiocarbonylamino,        C₁₋₈alkanylaminocarbonyl, di(C₁₋₈alkanyl)aminocarbonyl, and        C₁₋₆alkanyloxycarbonylamino;    -   R₁ is a substituent selected from the group consisting of        hydrogen, C₁₋₈alkanyl, C₂₋₈alkenyl, and C₂₋₈alkynyl;    -   R₂ is a substituent selected from the group consisting of        hydrogen; C₁₋₈alkanyl; C₂₋₈alkenyl; C₂₋₈alkynyl; C₆₋₁₀aryl; and        C₁₋₈cycloalkanyl; wherein C₁₋₈alkanyl is optionally substituted        with one to three substituents independently selected from the        group consisting of phenyl, amino, C₁₋₆alkanylamino,        di(C₁₋₆alkanyl)amino, C₁₋₆alkanyloxy, thioC₁₋₆alkanyloxy,        hydroxy, fluoro, chloro, cyano, aminocarbonyl,        C₁₋₈alkanylaminocarbonyl, di(C₁₋₈alkanyl)aminocarbonyl,        C₁₋₆alkanyloxycarbonyl, and aryloxy; and wherein any        aryl-containing substituents and C₁₋₈cycloalkanyl substituents        of R₂ are optionally substituted with one to three substituents        independently selected from the group consisting of C₁₋₈alkanyl,        C₂₋₈alkenyl, C₂₋₈alkynyl, C₁₋₈alkanyloxy, trifluoromethyl,        trifluoromethoxy, phenyl, halogen, cyano, hydroxy,        C₁₋₈alkanylthio, C₁₋₈alkanylsulfonyl, and        C₁₋₈alkanylsulfonylamino;    -   or R₁ and R₂ taken together with the nitrogen to which they are        attached form a 5-7 membered cycloheteroalkyl optionally        substituted with one to three substituents independently        selected from the group consisting of C₁₋₈alkanyl,        hydroxy(C₁₋₈)alkanyl, hydroxy, amino, C₁₋₆alkanylamino,        di(C₁₋₆alkanyl)amino, and halogen;    -   R₃ is a substituent selected from the group consisting of        hydrogen, C₁₋₈alkanyl, halo₁₋₃(C₁₋₈)alkanyl, C₂₋₈alkenyl,        C₂₋₈alkynyl, C₃₋₈cycloalkanyl, cycloalkanyl(C₁₋₈)alkanyl,        C₁₋₈alkanyloxy(C₁₋₈)alkanyl, C₁₋₈alkanylthio(C₁₋₈)alkanyl,        hydroxyC₁₋₈alkanyl, C₁₋₈alkanyloxycarbonyl,        halo₁₋₃(C₁₋₈)alkanylcarbonyl, formyl, thioformyl, carbamimidoyl,        phenylimino(C₁₋₈)alkanyl, phenyl(C₁₋₈)alkanyl,        phenyl(C₁₋₈)alkenyl, phenyl(C₁₋₈)alkynyl, naphthyl(C₁₋₈)alkanyl        and heteroaryl(C₁₋₈)alkanyl wherein the heteroaryl is selected        from the group consisting of benzo[1,3]dioxolyl, imidazolyl,        furanyl, pyridinyl, thienyl, indazolyl, indolyl, indolinyl,        isoindolinyl, isoquinolinyl, isothiazolyl, isoxazolyl, oxazolyl,        pyrazinyl, pyrazolyl, pyridazinyl, pyrimidinyl, pyrrolyl,        quinolinyl, isoquinolinyl, tetrazolyl, thiazolyl; wherein        phenyl, naphthyl and heteroaryl are optionally substituted with        one to three substituents independently selected from the group        consisting of C₁₋₆alkanyl, C₂₋₆alkenyl, C₁₋₆alkanyloxy, amino,        C₁₋₆alkanylamino, di(C₁₋₆alkanyl)amino, C₁₋₆alkanylcarbonyl,        C₁₋₆alkanylcarbonyloxy, C₁₋₆alkanylcarbonylamino,        C₁₋₆alkanylthio, C₁₋₆alkanylsulfonyl, halogen, hydroxy, cyano,        fluoro(C₁₋₆)alkanyl, thioureido, and fluoro(C₁₋₆)alkanyloxy;        alternatively, when phenyl and heteroaryl are optionally        substituted with alkanyl or alkanyloxy substituents attached to        adjacent carbon atoms, the two substituents can together form a        fused cyclic alkanyl or cycloheteroalkanyl selected from the        group consisting of —(CH₂)₃₋₅—, —O(CH₂)₂₋₄—, —(CH₂)₂₋₄O—, and        —O(CH₂)₁₋₃O—;    -   R₄ is one to three substituents independently selected from the        group consisting of hydrogen; C₁₋₆alkanyl; C₂₋₆alkenyl;        C₂₋₆alkynyl; aryl(C₂₋₆)alkynyl; C₁₋₆alkanyloxy; amino;        C₁₋₆alkanylamino; di(C₁₋₆alkanyl)amino; C₆₋₁₀arylamino wherein        C₆₋₁₀aryl is optionally substituted with one to three        substituents independently selected from the group consisting of        C₁₋₆alkanyl, C₁₋₆alkoxy, halogen, and hydroxy; formylamino;        pyridinylamino; C₁₋₆alkanylcarbonyl; C₁₋₆alkanylcarbonyloxy;        C₁₋₆alkanyloxycarbonyl; aminocarbonyl; C₁₋₆alkanylaminocarbonyl;        di(C₁₋₆alkanyl)aminocarbonyl; C₁₋₆alkanylcarbonylamino;        C₁₋₆alkanylthio; C₁₋₆alkanylsulfonyl; halogen; hydroxy; cyano;        hydroxycarbonyl; C₆₋₁₀aryl; chromanyl; chromenyl; furanyl;        imidazolyl; indazolyl; indolyl; indolinyl; isoindolinyl;        isoquinolinyl; isothiazolyl; isoxazolyl; naphthyridinyl;        oxazolyl; pyrazinyl; pyrazolyl; pyridazinyl; pyridinyl;        pyrimidinyl; pyrrolyl; quinazolinyl; quinolinyl; quinolizinyl;        quinoxalinyl; tetrazolyl; thiazolyl; thienyl; fluoroalkanyl and        fluoroalkanyloxy; or optionally; when R₄ is two substituents        attached to adjacent carbon atoms; the two substituents together        form a single fused moiety; wherein the fused moiety is        —(CH₂)₃₋₅—, —O(CH₂)₂₋₄—, —(CH₂)₂₋₄O—, —O(CH₂)₁₋₃O—, or        —S—C(NH₂)═N—;    -   R₅ is one to two substituents independently selected from the        group consisting of hydrogen, C₁₋₆alkanyl, C₂₋₆alkenyl,        C₁₋₆alkanyloxy, amino, C₁₋₆alkanylamino, di(C₁₋₆alkanyl)amino,        C₁₋₆alkanylcarbonyl, C₁₋₆alkanylcarbonyloxy,        C₁₋₆alkanyloxycarbonyl, C₁₋₆alkanylaminocarbonyl,        C₁₋₆alkanylcarbonylamino, C₁₋₆alkanylthio, C₁₋₆alkanylsulfonyl,        halogen, hydroxy, cyano, fluoro(C₁₋₆)alkanyl and        fluoro(C₁₋₆)alkanyloxy;    -   A is —(CH₂)_(m)—, wherein m is 2 or 3;    -   Y is O or S;    -   Z is O, S, NH, N(C₁₋₆alkanyl), N(OH), N(OC₁₋₆alkanyl), or        N(phenyl);        and enantiomers, diastereomers, tautomers, solvates, or        pharmaceutically acceptable salts thereof.

Embodiments of the present invention include compounds of Formula (I)wherein, preferably:

-   -   a) G is —C(Z)N(R₁)R₂, phenyl, or a heterocycle selected from the        group consisting of imidazolyl, triazolyl, tetrazolyl,        oxadiazolyl, thiadiazolyl, oxathiadiazolyl, imidazolinyl,        tetrahydropyrimidinyl, thienyl, pyrazolyl, pyrimidinyl,        triazinyl, isothiazolyl, isoxazolyl, oxazolyl, isoxadiazolyl,        and pyridinyl; wherein phenyl and the heterocycles of G are        optionally substituted with one to three substituents        independently selected from the group consisting of C₁₋₈alkanyl,        C₁₋₈alkanyloxy, hydroxy(C₁₋₈)alkanyl, carboxy(C₁₋₈)alkanyl,        C₁₋₈alkanylcarbonylamino, halogen, hydroxy, cyano, oxo, thioxo,        amino, C₁₋₆alkanylamino, di(C₁₋₆alkanyl)amino, C₁₋₈alkanylthio,        aminocarbonyl, aminothiocarbonyl, C₁₋₈alkanylaminocarbonyl,        di(C₁₋₈alkanyl)aminocarbonyl, and C₁₋₆alkanyloxycarbonylamino;    -   b) G is —C(Z)N(R₁)R₂, phenyl, or a heterocycle selected from the        group consisting of imidazolyl, tetrazolyl, oxadiazolyl,        thiadiazolyl, oxathiadiazolyl, imidazolinyl, thienyl, pyrazolyl,        pyrimidinyl, triazinyl, isothiazolyl, isoxazolyl, oxazolyl,        isoxadiazolyl, and pyridinyl; wherein phenyl and the        heterocycles of G (described herein) are optionally substituted        with one to three substituents independently selected from the        group consisting of C₁₋₄alkanyl, C₁₋₄alkanyloxy,        hydroxy(C₁₋₄)alkanyl, carboxy(C₁₋₄)alkanyl,        C₁₋₄alkanylcarbonylamino, hydroxy, cyano, oxo, thioxo, amino,        C₁₋₆alkanylamino, di(C₁₋₆alkanyl)amino, C₁₋₈alkanylthio,        aminocarbonyl, aminothiocarbonyl, C₁₋₈alkanylaminocarbonyl, and        di(C₁₋₈alkanyl)aminocarbonyl;    -   c) G is —C(Z)N(R₁)R₂, phenyl, or a heterocycle selected from the        group consisting of imidazolyl, tetrazolyl, oxadiazolyl,        thiadiazolyl, oxathiadiazolyl, thienyl, isothiazolyl,        isoxazolyl, isoxadiazolyl, and pyridinyl; wherein phenyl and the        heterocycles of G (described herein) are optionally substituted        with one to three substituents independently selected from the        group consisting of C₁₋₄alkanyl, C₁₋₄alkanyloxy,        hydroxy(C₁₋₄)alkanyl, C₁₋₄alkanylcarbonylamino, hydroxy, cyano,        oxo, thioxo, and aminocarbonyl;    -   d) R₁ is a substituent selected from the group consisting of        hydrogen and C₁₋₄alkanyl;    -   e) R₁ is selected from the group consisting of hydrogen, methyl,        ethyl, and propyl;    -   f) R₁ is selected from the group consisting of hydrogen, methyl,        or ethyl;    -   g) R₂ is selected from the group consisting of hydrogen;        C₁₋₄alkanyl; phenyl; and C₁₋₆cycloalkanyl; wherein C₁₋₄alkanyl        is optionally substituted with one to three substituents        independently selected from the group consisting of phenyl,        amino, C₁₋₆alkanylamino, di(C₁₋₆alkanyl)amino, C₁₋₄alkanyloxy,        hydroxy, fluoro, chloro, cyano, aminocarbonyl,        C₁₋₈alkanylaminocarbonyl, di(C₁₋₈alkanyl)aminocarbonyl, and        phenoxy; and wherein any phenyl-containing substituents and        C₁₋₆cycloalkanyl substituents of R₂ are optionally substituted        with one to three substituents independently selected from the        group consisting of C₁₋₈alkanyl, C₁₋₈alkanyloxy,        trifluoromethyl, phenyl, fluoro, hydroxy, C₁₋₈alkanylthio,        C₁₋₈alkanylsulfonyl, and C₁₋₈alkanylsulfonylamino; or R₁ and R₂        taken together with the nitrogen to which they are attached form        a 5-7 membered cycloheteroalkyl optionally substituted with one        to three substituents independently selected from the group        consisting of C₁₋₄alkanyl, hydroxy(C₁₋₄)alkanyl, hydroxy, amino,        C₁₋₆alkanylamino, di(C₁₋₆alkanyl)amino, and fluoro;    -   h) R₂ is selected from the group consisting of hydrogen,        C₁₋₄alkanyl, phenyl, and C₁₋₆cycloalkanyl, wherein C₁₋₄alkanyl        is optionally substituted with one to three substituents        independently selected from the group consisting of phenyl,        C₁₋₄alkanyloxy, hydroxy, fluoro, aminocarbonyl,        C₁₋₈alkanylaminocarbonyl, di(C₁₋₈alkanyl)aminocarbonyl, and        phenoxy; and wherein any phenyl-containing substituent of R₂ is        optionally substituted with one to three substituents        independently selected from the group consisting of C₁₋₆alkanyl,        C₁₋₆alkanyloxy, fluoro, hydroxy, and C₁₋₆alkanylthio; or R₁ and        R₂ taken together with the nitrogen to which they are attached        form a 5-7 membered cycloheteroalkyl optionally substituted with        one to three substituents independently selected from the group        consisting of C₁₋₄alkanyl and hydroxy;    -   i) R₂ is selected from the group consisting of hydrogen,        C₁₋₄alkanyl and phenyl, wherein C₁₋₄alkanyl is optionally        substituted with one to three substituents independently        selected from the group consisting of phenyl, C₁₋₄alkanyloxy,        hydroxy, fluoro, and phenoxy; and wherein any phenyl-containing        substituent of R₂ is optionally substituted with one to three        substituents independently selected from the group consisting of        C₁₋₆alkanyl, C₁₋₆alkanyloxy, fluoro, and hydroxy; or R₁ and R₂        taken together with the nitrogen to which they are attached form        a pyrrolidinyl or piperidinyl ring wherein said pyrrolidinyl or        piperidinyl is optionally substituted with a substituent        selected from the group consisting of C₁₋₃alkanyl and hydroxy;    -   j) R₃ is selected from the group consisting of hydrogen,        C₁₋₈alkanyl, C₂₋₈alkenyl, C₂₋₈alkynyl,        C₁₋₈alkanyloxy(C₁₋₈)alkanyl, C₁₋₈alkanylthio(C₁₋₈)alkanyl,        hydroxyC₁₋₈alkanyl, thioformyl, phenylimino(C₁₋₈)alkanyl,        phenyl(C₁₋₈)alkanyl, and heteroaryl(C₁₋₈)alkanyl wherein        heteroaryl is selected from the group consisting of        benzo[1,3]dioxolyl, imidazolyl, furanyl, pyridinyl, thienyl,        indolyl, indolinyl, isoquinolinyl, pyrazinyl, pyrazolyl,        pyridazinyl, pyrimidinyl, pyrrolyl, quinolinyl, isoquinolinyl,        tetrazolyl; wherein phenyl and heteroaryl are optionally        substituted with one to three substituents independently        selected from the group consisting of C₁₋₆alkanyloxy and        hydroxy; or optionally, when phenyl and heteroaryl are        optionally substituted with two substituents attached to        adjacent carbon atoms, the two substituents together form a        single fused moiety; wherein the moiety is selected from        —O(CH₂)₁₋₃O—;    -   k) R₃ is selected from the group consisting of hydrogen, methyl,        allyl, 2-methyl-allyl, propynyl, hydroxyethyl, methylthioethyl,        methoxyethyl, thioformyl, phenyliminomethyl, phenethyl, and        heteroaryl(C₁₋₈)alkanyl wherein the heteroaryl is selected from        the group consisting of benzo[1,3]dioxolyl, imidazolyl, furanyl,        pyridinyl, thienyl, pyrimidinyl, pyrrolyl, quinolinyl,        isoquinolinyl, tetrazolyl; wherein the phenyl in any        phenyl-containing substituent is optionally substituted with one        hydroxyl group;    -   l) R₃ is hydrogen, methyl, allyl, or heteroarylmethyl wherein        heteroaryl is selected from the group consisting of        benzo[1,3]dioxolyl, imidazolyl, furanyl, pyridinyl, and thienyl;    -   m) R₄ is one to three substituents independently selected from        the group consisting of hydrogen; C₁₋₆alkanyl; C₁₋₆alkanyloxy;        C₆₋₁₀arylamino wherein C₆₋₁₀aryl is optionally substituted with        one to three substituents independently selected from the group        consisting of C₁₋₆alkanyl; C₁₋₆alkoxy, halogen, and hydroxy;        formylamino; pyridinylamino; aminocarbonyl;        C₁₋₆alkanylaminocarbonyl; C₁₋₆alkanylcarbonylamino; halogen;        hydroxy; C₆₋₁₀aryl; chromanyl; chromenyl; furanyl; imidazolyl;        indazolyl; indolyl; indolinyl; isoindolinyl; isoquinolinyl;        isothiazolyl; isoxazolyl; naphthyridinyl; oxazolyl; pyrazinyl;        pyrazolyl; pyridazinyl; pyridinyl; pyrimidinyl; pyrrolyl;        quinazolinyl; quinolinyl; quinolizinyl; quinoxalinyl;        tetrazolyl; thiazolyl; and thienyl;    -   n) R₄ is one to two substituents independently selected from the        group consisting of hydrogen, C₁₋₄alkanyl, C₁₋₄alkanyloxy,        halogen, phenyl, furanyl, imidazolyl, indazolyl, indolyl,        indolinyl, isoindolinyl, isoquinolinyl, isothiazolyl,        isoxazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridazinyl,        pyridinyl, pyrimidinyl, pyrrolyl, quinolinyl, tetrazolyl,        thiazolyl, thienyl, and hydroxy;    -   o) R₄ is one to two substituents independently selected from the        group consisting of hydrogen, methyl, methoxy, bromo, fluoro,        α′- or β′-phenyl, α′- or β′-pyridinyl, α′- or β′-furanyl, and        hydroxy;    -   p) R₅ is one to two substituents independently selected from the        group consisting of hydrogen and halogen;    -   q) R₅ is hydrogen;    -   r) A is —(CH₂)₂₋₃—;    -   s) A is —(CH₂)₂—;    -   t) Y is O or S;    -   u) Z is O, NH, N(C₁₋₆alkanyl), N(OH), N(OC₁₋₆alkanyl), or        N(phenyl);    -   v) Z is O, NH, or N(OH);    -   w) Z is O or NH;    -   aa) G is —C(Z)N(R₁)R₂, phenyl, or a heterocycle selected from        the group consisting of tetrazolyl, oxadizolyl, furyl,        quinolinyl, thienyl, and pyridinyl; wherein phenyl and the        heterocycles of G are optionally substituted with one to three        substituents independently selected from the group consisting of        C₁₋₈alkanyl, C₁₋₈alkanyloxy, hydroxy(C₁₋₈)alkanyl,        carboxy(C₁₋₈)alkanyl, C₁₋₈alkanylcarbonylamino, halogen,        hydroxy, cyano, oxo, thioxo, amino, C₁₋₆alkanylamino,        di(C₁₋₆alkanyl)amino, C₁₋₈alkanylthio, aminocarbonyl,        aminothiocarbonyl, C₁₋₈alkanylaminocarbonyl,        di(C₁₋₈alkanyl)aminocarbonyl, and C₁₋₆alkanyloxycarbonylamino;    -   bb) G is —C(Z)N(R₁)R₂, phenyl, or a heterocycle selected from        the group consisting of tetrazolyl, oxadizolyl, furyl,        quinolinyl, thienyl, and pyridinyl; wherein phenyl and the        heterocycles of G are optionally substituted with one to three        substituents independently selected from the group consisting of        C₁₋₄alkanyl, C₁₋₄alkanyloxy, hydroxy(C₁₋₄)alkanyl,        C₁₋₄alkanylcarbonylamino, hydroxy, cyano, oxo, thioxo, and        aminocarbonyl;    -   cc) G is —C(Z)N(R₁)R₂; tetrazolyl; pyridinyl; oxadiazolyl        optionally substituted with oxo; or phenyl optionally        substituted with (C₁₋₈)alkanylcarbonylamino;    -   dd) G is —C(Z)N(R₁)R₂, 1H-tetrazol-4-yl,        4H-[1,2,4]-oxadiazol-5-oxo-3-yl, 2-methylcarbonylaminophenyl,        pyridin-3-yl or pyridin-4-yl;    -   dd) R₂ is selected from the group consisting of hydrogen and        C₁₋₄alkanyl; wherein C₁₋₄alkanyl is optionally substituted with        phenyl; or R₁ and R₂ taken together with the nitrogen to which        they are attached form a pyrrolidinyl wherein said pyrrolidinyl        is optionally substituted with hydroxy;    -   ee) R₂ is selected from the group consisting of hydrogen,        methyl, ethyl, and phenethyl; or R₁ and R₂ taken together with        the nitrogen to which they are attached form pyrrolidin-1-yl,        3-hydoxypyrrolidin-1-yl or 3-(S)-hydoxypyrrolidin-1-yl;    -   ff) R₃ is selected from the group consisting of hydrogen,        C₁₋₈alkanyl, C₂₋₈alkenyl, C₂₋₈alkynyl,        C₁₋₈alkanyloxy(C₁₋₈)alkanyl, C₁₋₈alkanylthio(C₁₋₈)alkanyl,        hydroxyC₁₋₈alkanyl, thioformyl, phenylimino(C₁₋₈)alkanyl,        phenyl(C₁₋₈)alkanyl, and heteroaryl(C₁₋₈)alkanyl wherein        heteroaryl is selected from the group consisting of        benzo[1,3]dioxolyl, imidazolyl, furanyl, pyridinyl, thienyl,        indolyl, indolinyl, isoquinolinyl, pyrazinyl, pyrazolyl,        pyridazinyl, pyrimidinyl, pyrrolyl, quinolinyl, thiazolyl,        isoquinolinyl, tetrazolyl; wherein phenyl and heteroaryl are        optionally substituted with one to three substituents        independently selected from the group consisting of        C₁₋₆alkanyloxy and hydroxy; or optionally, when phenyl and        heteroaryl are optionally substituted with two substituents        attached to adjacent carbon atoms, the two substituents together        form a single fused moiety; wherein the moiety is selected from        —O(CH₂)₁₋₃O—;    -   gg) R₃ is selected from the group consisting of hydrogen,        methyl, methylbutenyl, propenyl, benzyl, phenethyl, and        heteroaryl(C₁₋₈)alkanyl wherein the heteroaryl is selected from        the group consisting of imidazolyl, furanyl, pyridinyl, thienyl,        and thiazolyl;    -   hh) R₃ is selected from the group consisting of hydrogen,        methyl, 3-methyl-2-butenyl, 2-propenyl, benzyl, 2-phenethyl,        pyridin-2-ylmethyl, fur-3-ylmethyl, thiophene-2-ylmethyl,        1H-imidazol-2-ylmethyl, and thiazol-2-ylmethyl;    -   ii) R₄ is one to two substituents independently selected from        the group consisting of hydrogen, methyl, phenyl, bromo, fluoro,        aminocarbonyl, chloro and hydroxy;    -   jj) R₄ is one to two substituents independently selected from        the group consisting of hydrogen, α′-hydroxy and α′-methoxy;    -   kk) R₄ is unsubstituted or substituted at the α′ position;    -   ll) R₄ is hydrogen and Y is O;    -   mm) R₄ is α′-hydroxy and Y is O;    -   nn) R₄ is hydrogen and Y is S;    -   oo) R₄ is α′-hydroxy and Y is S;        and combinations of a) through oo) above.

One embodiment of the present invention is a compound of Formula (I)wherein:

-   -   G is —C(Z)N(R₁)R₂, phenyl, or a heterocycle selected from the        group consisting of imidazolyl, triazolyl, tetrazolyl,        oxadiazolyl, thiadiazolyl, oxathiadiazolyl, imidazolinyl,        tetrahydropyrimidinyl, thienyl, pyrazolyl, pyrimidinyl,        triazinyl, isothiazolyl, isoxazolyl, oxazolyl, isoxadiazolyl,        and pyridinyl; wherein phenyl and the heterocycles of G are        optionally substituted with one to three substituents        independently selected from the group consisting of C₁₋₈alkanyl,        C₁₋₈alkanyloxy, hydroxy(C₁₋₈)alkanyl, carboxy(C₁₋₈)alkanyl,        C₁₋₈alkanylcarbonylamino, halogen, hydroxy, cyano, oxo, thioxo,        amino, C₁₋₆alkanylamino, di(C₁₋₆alkanyl)amino, C₁₋₈alkanylthio,        aminocarbonyl, aminothiocarbonyl, C₁₋₈alkanylaminocarbonyl,        di(C₁₋₈alkanyl)aminocarbonyl, and C₁₋₆alkanyloxycarbonylamino;    -   R₁ is hydrogen or C₁₋₄alkanyl;    -   R₂ is selected from the group consisting of hydrogen;        C₁₋₄alkanyl; phenyl; and C₁₋₆cycloalkanyl; wherein C₁₋₄alkanyl        is optionally substituted with one to three substituents        independently selected from the group consisting of phenyl,        amino, C₁₋₆alkanylamino, di(C₁₋₆alkanyl)amino, C₁₋₄alkanyloxy,        hydroxy, fluoro, chloro, cyano, aminocarbonyl,        C₁₋₈alkanylaminocarbonyl, di(C₁₋₈alkanyl)aminocarbonyl, and        phenoxy; and wherein the phenyl and C₁₋₆cycloalkanyl        substituents of R₂ are optionally substituted with one to three        substituents independently selected from the group consisting of        C₁₋₈alkanyl, C₁₋₈alkanyloxy, trifluoromethyl, phenyl, fluoro,        hydroxy, C₁₋₈alkanylthio, C₁₋₈alkanylsulfonyl, and        C₁₋₈alkanylsulfonylamino; or R₁ and R₂ taken together with the        nitrogen to which they are attached form a 5-7 membered        cycloheteroalkyl optionally substituted with one to three        substituents independently selected from the group consisting of        C₁₋₄alkanyl, hydroxy(C₁₋₄)alkanyl, hydroxy, amino,        C₁₋₆alkanylamino, di(C₁₋₆alkanyl)amino, and fluoro;    -   R₃ is selected from the group consisting of hydrogen,        C₁₋₈alkanyl, C₂₋₈alkenyl, C₂₋₈alkynyl,        C₁₋₈alkanyloxy(C₁₋₈)alkanyl, C₁₋₈alkanylthio(C₁₋₈)alkanyl,        hydroxyC₁₋₈alkanyl, thioformyl, phenylimino(C₁₋₈)alkanyl,        phenyl(C₁₋₈)alkanyl, and heteroaryl(C₁₋₈)alkanyl wherein        heteroaryl is selected from the group consisting of        benzo[1,3]dioxolyl, imidazolyl, furanyl, pyridinyl, thienyl,        indolyl, indolinyl, isoquinolinyl, pyrazinyl, pyrazolyl,        pyridazinyl, pyrimidinyl, pyrrolyl, quinolinyl, isoquinolinyl,        tetrazolyl; wherein phenyl and heteroaryl are optionally        substituted with one to three substituents independently        selected from the group consisting of C₁₋₆alkanyloxy and        hydroxy; or optionally, when phenyl and heteroaryl are        optionally substituted with two substituents attached to        adjacent carbon atoms, the two substituents together form a        single fused moiety; wherein the moiety is selected from        —O(CH₂)₁₋₃O—;    -   R₄ is one to three substituents independently selected from the        group consisting of hydrogen; C₁₋₆alkanyl; C₁₋₆alkanyloxy;        C₆₋₁₀arylamino wherein C₆₋₁₀aryl is optionally substituted with        one to three substituents independently selected from the group        consisting of C₁₋₆alkanyl; C₁₋₆alkoxy, halogen, and hydroxy;        formylamino; pyridinylamino; aminocarbonyl;        C₁₋₆alkanylaminocarbonyl; C₁₋₆alkanylcarbonylamino; halogen;        hydroxy; C₆₋₁₀aryl; chromanyl; chromenyl; furanyl; imidazolyl;        indazolyl; indolyl; indolinyl; isoindolinyl; isoquinolinyl;        isothiazolyl; isoxazolyl; naphthyridinyl; oxazolyl; pyrazinyl;        pyrazolyl; pyridazinyl; pyridinyl; pyrimidinyl; pyrrolyl;        quinazolinyl; quinolinyl; quinolizinyl; quinoxalinyl;        tetrazolyl; thiazolyl; and thienyl;    -   R₅ is one to two substituents independently selected from the        group consisting of hydrogen and halogen;    -   A is CH₂CH₂;    -   Y is O or S;    -   Z is O, NH, N(C₁₋₆alkanyl), N(OH), N(OC₁₋₆alkanyl), or        N(phenyl); and    -   enantiomers, diastereomers, tautomers, solvates, and        pharmaceutically acceptable salts thereof.

Another embodiment of the present invention is a compound of Formula (I)wherein:

-   -   G is —C(Z)N(R₁)R₂, phenyl, or a heterocycle selected from the        group consisting of imidazolyl, tetrazolyl, oxadiazolyl,        thiadiazolyl, oxathiadiazolyl, imidazolinyl, thienyl, pyrazolyl,        pyrimidinyl, triazinyl, isothiazolyl, isoxazolyl, oxazolyl,        isoxadiazolyl, and pyridinyl; wherein phenyl and the        heterocycles of G (described herein) are optionally substituted        with one to three substituents independently selected from the        group consisting of C₁₋₄alkanyl, C₁₋₄alkanyloxy,        hydroxy(C₁₋₄)alkanyl, carboxy(C₁₋₄)alkanyl,        C₁₋₄alkanylcarbonylamino, hydroxy, cyano, oxo, thioxo, amino,        C₁₋₆alkanylamino, di(C₁₋₆alkanyl)amino, C₁₋₈alkanylthio,        aminocarbonyl, aminothiocarbonyl, C₁₋₈alkanylaminocarbonyl, and        di(C₁₋₈alkanyl)aminocarbonyl;    -   R₁ is selected from the group consisting of hydrogen, methyl,        ethyl, and propyl;    -   R₂ is selected from the group consisting of hydrogen,        C₁₋₄alkanyl, phenyl, and C₁₋₆cycloalkanyl; wherein C₁₋₄alkanyl        is optionally substituted with one to three substituents        independently selected from the group consisting of phenyl,        C₁₋₄alkanyloxy, hydroxy, fluoro, aminocarbonyl,        C₁₋₈alkanylaminocarbonyl, di(C₁₋₈alkanyl)aminocarbonyl, and        phenoxy; and wherein any phenyl-containing substituent of R₂ is        optionally substituted with one to three substituents        independently selected from the group consisting of C₁₋₆alkanyl,        C₁₋₆alkanyloxy, fluoro, hydroxy, and C₁₋₆alkanylthio; or R₁ and        R₂ taken together with the nitrogen to which they are attached        form a pyrrolidinyl or piperidinyl ring wherein said        pyrrolidinyl or piperidinyl is optionally substituted with a        substituent selected from the group consisting of C₁₋₃alkanyl        and hydroxy;    -   R₃ is selected from the group consisting of hydrogen, methyl,        allyl, 2-methyl-allyl, propynyl, hydroxyethyl, methylthioethyl,        methoxyethyl, thioformyl, phenyliminomethyl, phenethyl, and        heteroaryl(C₁₋₈)alkanyl wherein the heteroaryl is selected from        the group consisting of benzo[1,3]dioxolyl, imidazolyl, furanyl,        pyridinyl, thienyl, pyrimidinyl, pyrrolyl, quinolinyl,        isoquinolinyl, tetrazolyl wherein the phenyl in any        phenyl-containing substituent is optionally substituted with one        hydroxyl group;    -   R₄ is one to two substituents independently selected from the        group consisting of hydrogen, C₁₋₄alkanyl, C₁₋₄alkanyloxy,        halogen, phenyl, furanyl, imidazolyl, indazolyl, indolyl,        indolinyl, isoindolinyl, isoquinolinyl, isothiazolyl,        isoxazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridazinyl,        pyridinyl, pyrimidinyl, pyrrolyl, quinolinyl, tetrazolyl,        thiazolyl, thienyl, and hydroxy;    -   R₅ is hydrogen;    -   A is CH₂CH₂;    -   Y is O or S;    -   Z is O, NH, or N(OH); and    -   enantiomers, diastereomers, tautomers, solvates, and        pharmaceutically acceptable salts thereof.

Another embodiment of the present invention is directed to compositionscomprising a compound of Formula (I) wherein:

-   -   G is selected from —C(Z)N(R₁)R₂, phenyl, or a heterocycle        selected from the group consisting of imidazolyl, tetrazolyl,        oxadiazolyl, thiadiazolyl, oxathiadiazolyl, thienyl,        isothiazolyl, isoxazolyl, isoxadiazolyl, and pyridinyl; wherein        phenyl and the heterocycles of G are optionally substituted with        one to three substituents independently selected from the group        consisting of C₁₋₄alkanyl, C₁₋₄alkanyloxy, hydroxy(C₁₋₄)alkanyl,        C₁₋₄alkanylcarbonylamino, hydroxy, cyano, oxo, thioxo, and        aminocarbonyl;    -   R₁ is hydrogen, methyl, or ethyl;    -   R₂ is independently selected from the group consisting of        hydrogen, C₁₋₄alkanyl and phenyl; wherein C₁₋₄alkanyl is        optionally substituted with one to three substituents        independently selected from the group consisting of phenyl,        C₁₋₄alkanyloxy, hydroxy, fluoro, and phenoxy; and wherein any        phenyl-containing substituent of R₂ is optionally substituted        with one to three substituents independently selected from the        group consisting of C₁₋₆alkanyl, C₁₋₆alkanyloxy, fluoro, and        hydroxy; or R₁ and R₂ taken together with the nitrogen to which        they are attached form a pyrrolidinyl or piperidinyl ring        wherein said pyrrolidinyl or piperidinyl are optionally        substituted with a substituent selected from the group        consisting of C₁₋₃alkanyl and hydroxy;    -   R₃ is hydrogen, methyl, allyl, or heteroarylmethyl wherein        heteroaryl is selected from the group consisting of        benzo[1,3]dioxolyl, imidazolyl, furanyl, pyridinyl, and thienyl;    -   R₄ is one to two substituents independently selected from the        group consisting of hydrogen, C₁₋₄alkanyl, C₁₋₄alkanyloxy,        halogen, phenyl, furanyl, imidazolyl, indazolyl, indolyl,        indolinyl, isoindolinyl, isoquinolinyl, isothiazolyl,        isoxazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridazinyl,        pyridinyl, pyrimidinyl, pyrrolyl, quinolinyl, tetrazolyl,        thiazolyl, thienyl, and hydroxy;    -   A is CH₂CH₂;    -   Y is O or S;    -   Z is O or NH; and    -   enantiomers, diasteromers, tautomers, solvates, and        pharmaceutically acceptable salts thereof.

Another embodiment of the present invention is directed to compounds ofFormula (I) wherein:

-   -   G is —C(Z)N(R₁)R₂, phenyl, or a heterocycle selected from the        group consisting of tetrazolyl, oxadiazolyl, furyl, quinolinyl,        thienyl, and pyridinyl; wherein phenyl and the heterocycles of G        are optionally substituted with one to three substituents        independently selected from the group consisting of C₁₋₈alkanyl,        C₁₋₈alkanyloxy, hydroxy(C₁₋₈)alkanyl, carboxy(C₁₋₈)alkanyl,        C₁₋₈alkanylcarbonylamino, halogen, hydroxy, cyano, oxo, thioxo,        amino, C₁₋₆alkanylamino, di(C₁₋₆alkanyl)amino, C₁₋₈alkanylthio,        aminocarbonyl, aminothiocarbonyl, C₁₋₈alkanylaminocarbonyl,        di(C₁₋₈alkanyl)aminocarbonyl, and C₁₋₆alkanyloxycarbonylamino;    -   R₁ is C₁₋₄ alkanyl, or hydrogen;    -   R₂ is hydrogen or C₁₋₄ alkanyl optionally substituted with        phenyl;    -   or R₁ and R₂ taken together with the nitrogen to which they are        attached form a pyrrolidinyl ring optionally substituted with        hydroxy;    -   Z is NH or oxygen;    -   R₃ is pyridinyl(C₁₋₈)alkanyl, furyl(C₁₋₈)alkanyl, C₁₋₅ alkanyl,        hydrogen, C₂₋₈ alkenyl, thienyl(C₁₋₈)alkanyl,        imidazolyl(C₁₋₈)alkanyl, phenyl(C₁₋₈)alkanyl, or        thiazolyl(C₁₋₈)alkanyl;    -   R₄ is hydrogen, C₁₋₆ alkanyl, C₁₋₆ alkanyloxy, hydroxy, halogen,        aminocarbonyl, or phenyl;    -   R₅ is hydrogen;    -   A is CH₂CH₂;    -   Y is O or S;    -   Z is O or NH; and    -   enantiomers, diastereomers, tautomers, solvates, and        pharmaceutically acceptable salts thereof.

Another embodiment of the present invention is directed to compounds ofFormula (I) wherein:

-   -   G is —C(Z)N(R₁)R₂; tetrazolyl, oxadiazolyl optionally        substituted with oxo; phenyl optionally substituted with        (C₁₋₈)alkanylcarbonylamino; or pyridinyl;    -   R₁ is C₁₋₄ alkanyl, or hydrogen;    -   R₂ is hydrogen or C₁₋₄ alkanyl optionally substituted with        phenyl;    -   or R₁ and R₂ taken together with the nitrogen to which they are        attached form a pyrrolidinyl ring optionally substituted with        hydroxy;    -   Z is NH or oxygen;    -   R₃ is pyridinyl(C₁₋₈)alkanyl, furyl(C₁₋₈)alkanyl, C₁₋₅ alkanyl,        hydrogen, C₂₋₈ alkenyl, thienyl(C₁₋₈)alkanyl,        imidazolyl(C₁₋₈)alkanyl, phenyl(C₁₋₈)alkanyl, or        thiazolyl(C₁₋₈)alkanyl;    -   R₄ is hydrogen, α′-hydroxy, or α′-methoxy;    -   R₅ is hydrogen;    -   A is CH₂CH₂;    -   Y is O or S;    -   Z is O or NH; and    -   enantiomers, diastereomers, tautomers, solvates, and        pharmaceutically acceptable salts thereof.

Another embodiment of the present invention is directed to compounds ofFormula (I) wherein:

-   -   G is —C(Z)N(R₁)R₂, 1H-tetrazol-4-yl,        4H-[1,2,4]-oxadiazol-5-oxo-3-yl, 2-methylcarbonylaminophenyl,        3-furyl, quinolin-3-yl, thiophen-3-yl, pyridin-3-yl or        pyridin-4-yl,    -   R₁ is hydrogen, ethyl, or methyl,    -   R₂ is methyl, ethyl, phenethyl, or hydrogen;    -   or R₁ and R₂ taken together with the nitrogen to which they are        attached form pyrrolidin-1-yl, 3-hydroxypyrrolidin-1-yl, or        3-(S)-hydroxypyrrolidin-1-yl;    -   Z is NH or oxygen,    -   R₃ is pyridin-2-ylmethyl, fur-3-ylmethyl, methyl, hydrogen,        3-methyl-2-butenyl, thiophene-2-ylmethyl, 2-propenyl,        1H-imidazol-2-ylmethyl, 2-phenethyl, thiazol-2-ylmethyl, benzyl,        or allyl;    -   R₄ is hydrogen, α′-methyl, α′-phenyl, β″-bromo, β″-fluoro,        α′-aminocarbonyl, α′-chloro, α′-methoxy; or α′-hydroxy;    -   R₅ is hydrogen;    -   A is CH₂CH₂;    -   Y is O or S;    -   Z is O or NH; and    -   enantiomers, diastereomers, tautomers, solvates, and        pharmaceutically acceptable salts thereof.

Another embodiment of the present invention is directed to compounds ofFormula (I) wherein:

-   -   G is —C(Z)N(R₁)R₂, 1H-tetrazol-4-yl,        4H-[1,2,4]-oxadiazol-5-oxo-3-yl, 2-methylcarbonylaminophenyl,        pyridin-3-yl or pyridin-4-yl;    -   R₁ is hydrogen, ethyl, or methyl;    -   R₂ is methyl, ethyl, phenethyl, or hydrogen;    -   or R₁ and R₂ taken together with the nitrogen to which they are        attached form pyrrolidin-1-yl, 3-hydroxypyrrolidin-1-yl, or        3-(S)-hydroxypyrrolidin-1-yl;    -   Z is NH or oxygen;    -   R₃ is pyridin-2-ylmethyl, fur-3-ylmethyl, methyl, hydrogen,        3-methyl-2-butenyl, thiophene-2-ylmethyl, 2-propenyl,        1H-imidazol-2-ylmethyl, 2-phenethyl, thiazol-2-ylmethyl, or        benzyl;    -   R₄ is hydrogen, α′-hydroxy, or α′-methoxy;    -   R₅ is hydrogen;    -   A is CH₂CH₂;    -   Y is O or S;    -   Z is O or NH; and    -   enantiomers, diastereomers, tautomers, solvates, and        pharmaceutically acceptable salts thereof.

In certain embodiments of Formula (I) when R₁ and R₂ are taken togetherwith the nitrogen to which they are attached to form a 5-7 memberedcycloheteroalkyl optionally substituted with one to three substituentsindependently selected from the group consisting of C₁₋₈alkanyl,hydroxy(C₁₋₈)alkyanyl, hydroxy, amino, C₁₋₆alkanylamino,di(C₁₋₆alkanyl)amino, and halogen; Z is oxygen.

In certain embodiments of Formula (I) when R₁ and R₂ are taken togetherwith the nitrogen to which they are attached to form a pyrrolidinyl ringoptionally substituted with hydroxy, Z is oxygen.

Another embodiment of the present invention is a compound of Formula (I)wherein:

-   -   G is selected from —C(Z)N(R₁)R₂, 2-methylcarbonylaminophenyl,        2-aminocarbonyl-phenyl, 1H-tetrazol-4-yl,        2-methyl-tetrazol-5-yl, 4H-[1,2,4]-oxadiazol-5-oxo-3-yl,        4H-[1,2,4]-oxadiazol-5-thioxo-3-yl,        4H-[1,2,4]thiadiazol-5-oxo-3-yl,        [1,2,3,5]oxathiadiazol-2-oxo-4-yl, or pyridin-3-yl;    -   R₁ is hydrogen, methyl, or ethyl;    -   R₂ is selected from the group consisting of hydrogen,        C₁₋₄alkanyl and phenyl; wherein C₁₋₄alkanyl is optionally        substituted with one to three substituents independently        selected from the group consisting of phenyl, C₁₋₄alkanyloxy,        hydroxy, fluoro, and phenoxy; and wherein any phenyl-containing        substituent of R₂ is optionally substituted with one to three        substituents independently selected from the group consisting of        C₁₋₆alkanyl, C₁₋₆alkanyloxy, fluoro, and hydroxy;    -   or R₁ and R₂ taken together with the nitrogen to which they are        attached form a pyrrolidinyl or piperidinyl ring;    -   R₃ is selected from the group consisting of hydrogen,        C₁₋₈alkanyl, C₂₋₈alkenyl, C₂₋₈alkynyl,        C₁₋₈alkanyloxy(C₁₋₈)alkanyl, C₁₋₈alkanylthio(C₁₋₈)alkanyl,        hydroxyC₁₋₈alkanyl, thioformyl, phenylimino(C₁₋₈)alkanyl,        phenyl(C₁₋₈)alkanyl, and heteroaryl(C₁₋₈)alkanyl wherein        heteroaryl is selected from the group consisting of hydrogen,        methyl, allyl, or heteroarylmethyl; wherein heteroaryl is        selected from the group consisting of benzo[1,3]dioxolyl,        imidazolyl, furanyl, pyridinyl, and thienyl; wherein phenyl and        heteroaryl are optionally substituted with one to three        substituents independently selected from the group consisting of        C₁₋₆alkanyloxy and hydroxy; or optionally, when phenyl and        heteroaryl are optionally substituted with two substituents        attached to adjacent carbon atoms, the two substituents together        form a single fused moiety; wherein the moiety is selected from        —O(CH₂)₁₋₃O—;    -   R₄ is one to three substituents independently selected from the        group consisting of hydrogen, C₁₋₄alkanyl, C₁₋₄alkanyloxy,        halogen, phenyl, furanyl, imidazolyl, indazolyl, indolyl,        indolinyl, isoindolinyl, isoquinolinyl, isothiazolyl,        isoxazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridazinyl,        pyridinyl, pyrimidinyl, pyrrolyl, quinolinyl, tetrazolyl,        thiazolyl, thienyl, and hydroxy;    -   R₅ is hydrogen;    -   A is CH₂CH₂;    -   Y is O or S;    -   Z is O or NH; and        enantiomers, diastereomers, tautomers, solvates, and        pharmaceutically acceptable salts thereof.

Another embodiment of the present invention is directed to compositionscomprising a compound of Formula (I) wherein G is independently selectedfrom —C(Z)N(R₁)R₂, 2-methylcarbonylaminophenyl, 2-aminocarbonyl-phenyl,1H-tetrazol-4-yl, 2-methyl-tetrazol-5-yl,4H-[1,2,4]-oxadiazol-5-oxo-3-yl, 4H-[1,2,4]-oxadiazol-5-thioxo-3-yl,4H-[1,2,4]thiadiazol-5-oxo-3-yl, [1,2,3,5]oxathiadiazol-2-oxo-4-yl, andpyridin-3-yl; R₁ is hydrogen, methyl, or ethyl; R₂ is a substituentselected from the group consisting of hydrogen, C₁₋₄alkanyl and phenyl;wherein C₁₋₄alkanyl is optionally substituted with one to threesubstituents independently selected from the group consisting of phenyl,C₁₋₄alkanyloxy, hydroxy, and 2,6-dimethyl-phenoxy; and wherein the anyphenyl-containing substituent of R₂ is optionally substituted with oneto three substituents independently selected from the group consistingof C₁₋₆alkanyl, C₁₋₆alkanyloxy, fluoro, and hydroxy; or R₁ and R₂ takentogether with the nitrogen to which they are attached form apyrrolidinyl or piperidinyl ring wherein said pyrrolidinyl orpiperidinyl is optionally substituted with a substituent selected fromthe group consisting of C₁₋₃alkanyl and hydroxy; R₃ is a substituentselected from the group consisting of benzo[1,3]dioxol-5-ylmethyl,carbamimidoyl, 1-H-imidazol-4-ylmethyl, phenyliminomethyl,1-prop-2-ynyl, thioformyl, 2-hydroxyphenyl-methyl, hydroxy-ethyl,methoxy-ethyl, 2-methyl-allyl, 2-methyl-but-2-enyl, allyl,furan-3-ylmethyl, H, Me, methylthioethyl, phenethyl, pyridin-2-ylmethyl, and thiophen-2-ylmethyl; R₄ is one to two substituentsindependently selected from the group consisting of hydrogen,C₁₋₄alkanyl, C₁₋₄alkanyloxy, halogen, phenyl, furanyl, imidazolyl,indazolyl, indolyl, indolinyl, isoindolinyl, isoquinolinyl,isothiazolyl, isoxazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridazinyl,pyridinyl, pyrimidinyl, pyrrolyl, quinolinyl, tetrazolyl, thiazolyl,thienyl, and hydroxy; R₅ is H; A is CH₂CH₂; Y is O or S; and Z is O orNH.

Another embodiment of the present invention is directed to compositionscomprising a compound of Formula (I) wherein G is selected from—C(Z)N(R₁)R₂, 2-methylcarbonylaminophenyl, 2-aminocarbonyl-phenyl,1H-tetrazol-4-yl, 2-methyl-tetrazol-5-yl,4H-[1,2,4]-oxadiazol-5-oxo-3-yl, 4H-[1,2,4]-oxadiazol-5-thioxo-3-yl,4H-[1,2,4]thiadiazol-5-oxo-3-yl, [1,2,3,5]oxathiadiazol-2-oxo-4-yl, orpyridin-3-yl; R₁ is hydrogen, methyl, or ethyl; R₂ is a substituentselected from the group consisting of hydrogen, C₁₋₄alkanyl and phenyl;wherein C₁₋₄alkanyl is optionally substituted with one to threesubstituents independently selected from the group consisting of phenyl,methoxy, hydroxy, and 2,6-dimethyl-phenoxy; and wherein anyphenyl-containing substituent of R₂ is optionally substituted with oneto three substituents independently selected from the group consistingof C₁₋₆alkanyl, C₁₋₆alkanyloxy, fluoro, and hydroxy; or R₁ and R₂ takentogether with the nitrogen to which they are attached form apyrrolidinyl or piperidinyl ring wherein said pyrrolidinyl orpiperidinyl are optionally substituted with a substituent selected fromthe group consisting of C₁₋₃alkanyl and hydroxy; R₃ is a substituentselected from the group consisting of benzo[1,3]dioxol-5-ylmethyl,carbamimidoyl, 1-H-imidazol-4-yl methyl, phenyliminomethyl,1-prop-2-ynyl, thioformyl, 2-hydroxyphenyl-methyl, hydroxyethyl,methoxyethyl, allyl, furan-3-yl methyl, H, Me, methylthioethyl, andphenethyl; R₄ is one to two substituents independently selected from thegroup consisting of hydrogen, methyl, methoxy, bromo, fluoro, α′- orβ′-phenyl, α′- or β′-pyridinyl, α′- or β′-furanyl, and hydroxy; R₅ is H;A is CH₂CH₂; Y is O or S; and Z is O or NH.

Another embodiment of the present invention is directed to compositionscomprising a compound of Formula (I) wherein G is selected from—C(Z)N(R₁)R₂, 2-methylcarbonylaminophenyl, 2-aminocarbonyl-phenyl,1H-tetrazol-4-yl, 2-methyl-tetrazol-5-yl,4H-[1,2,4]-oxadiazol-5-oxo-3-yl, 4H-[1,2,4]-oxadiazol-5-thioxo-3-yl,4H-[1,2,4]thiadiazol-5-oxo-3-yl, [1,2,3,5]oxathiadiazol-2-oxo-4-yl, orpyridin-3-yl; R₁ is hydrogen, methyl, or ethyl; R₂ is a substituentselected from the group consisting of hydrogen, C₁₋₄alkanyl and phenyl;wherein C₁₋₄alkanyl is optionally substituted with one to threesubstituents independently selected from the group consisting of phenyl,methoxy, hydroxy, and 2,6-dimethyl-phenoxy; and wherein anyphenyl-containing substituent of R₂ is optionally substituted with oneto three substituents independently selected from the group consistingof C₁₋₆alkanyl, C₁₋₆alkanyloxy, fluoro, and hydroxy; alternatively R₁and R₂ are taken together with the nitrogen to which they are attachedto form a pyrrolidinyl or piperidinyl ring wherein said pyrrolidinyl orpiperidinyl are optionally substituted with a substituent selected fromthe group consisting of C₁₋₃alkanyl and hydroxy; R₃ is a substituentselected from the group consisting of H, benzo[1,3]dioxol-5-ylmethyl,1-H-imidazol-4-yl methyl, furan-3-ylmethyl, pyridin-2-ylmethyl, andphenyliminomethyl; R₄ is a substituent independently selected from thegroup consisting of hydrogen, methyl, methoxy, bromo, fluoro α′- orβ′-phenyl, α′- or β′-pyridinyl, α′- or β′-furanyl, and hydroxy; R₅ is H;A is CH₂CH₂; Y is O or S; and Z is O or NH.

Another embodiment of the present invention is directed to a compound ofFormula (I) wherein R₄ is preferably substituted at the α′- orβ′-position of Formula (I).

Another embodiment of the present invention is directed to compositionscomprising a compound selected from the group consisting of:

-   a compound of Formula (I) wherein G is N,N-diethylaminocarbonyl; R³    is 1H-imidazol-2-yl-methyl; R⁴ is α′-hydroxy; R⁵ is H; Y is O; and A    is —CH₂CH₂—;-   a compound of Formula (I) wherein G is N,N-diethylaminocarbonyl; R³    is furan-3-yl-methyl; R⁴ is α′-hydroxy; R⁵ is H; Y is O; and A is    —CH₂CH₂—;-   a compound of Formula (I) wherein G is N,N-diethylaminocarbonyl; R³    is H; R⁴ is α′-hydroxy; R⁵ is H; Y is O; and A is —CH₂CH₂—;-   a compound of Formula (I) wherein G is N,N-diethylaminocarbonyl; R³    is H; R⁴ is α′-methoxy; R⁵ is H; Y is O; and A is —CH₂CH₂—;-   a compound of Formula (I) wherein G is N,N-diethylaminocarbonyl; R³    is pyridin-2-yl-methyl; R⁴ is H; R⁵ is H; Y is O; A is —CH₂CH₂—;-   a compound of Formula (I) wherein G is N,N-diethylaminocarbonyl; R³    is furan-3-yl-methyl; R⁴ is H; R⁵ is H; Y is O; and A is —CH₂CH₂—;-   a compound of Formula (I) wherein G is N,N-diethylaminocarbonyl; R³    is thien-2-yl-methyl; R⁴ is H; R⁵ is H; Y is O; and A is —CH₂CH₂—;-   a compound of Formula (I) wherein G is N,N-diethylaminocarbonyl; R³    is benzyl; R⁴ is H; R⁵ is H; Y is O; and A is —CH₂CH₂—;-   a compound of Formula (I) wherein G is pyridin-3-yl; R³ is    furan-3-yl methyl; R⁴ is H; R⁵ is H; Y is O; and A is —CH₂CH₂—;-   a compound of Formula (I) wherein G is N,N-diethylaminocarbonyl; R³    is furan-2-yl methyl; R⁴ is H; R⁵ is H; Y is O; and A is —CH₂CH₂—;-   a compound of Formula (I) wherein G is N,N-diethylaminocarbonyl; R³    is H; R⁴ is α′-methyl; R⁵ is H; Y is O; and A is —CH₂CH₂—;-   a compound of Formula (I) wherein G is N,N-diethylaminocarbonyl; R³    is H; R⁴ is α′-phenyl; R⁵ is H; Y is O; and A is —CH₂CH₂—;-   a compound of Formula (I) wherein G is N,N-diethylaminocarbonyl; R³    is H; R⁴ is H; R⁵ is H; Y is O; and A is —CH₂CH₂—;-   a compound of Formula (I) wherein G is N,N-diethylaminocarbonyl; R³    is H; R⁴ is H; R⁵ is H; Y is O; and A is —CH₂CH₂—;-   a compound of Formula (I) wherein G is N,N-diethylaminocarbonyl; R³    is H; R⁴ is β″-bromo; R⁵ is H; Y is O; and A is —CH₂CH₂—;-   a compound of Formula (I) wherein G is N,N-diethylaminocarbonyl; R³    is H; R⁴ is H; R⁵ is H; Y is O; and A is —CH₂CH₂—;-   a compound of Formula (I) wherein G is N,N-diethylaminocarbonyl; R³    is H; R⁴ is α′-chloro; R⁵ is H; Y is O; and A is —CH₂CH₂—;-   a compound of Formula (I) wherein G is N,N-diethylaminocarbonyl; R³    is H; R⁴ is R″-fluoro; R⁵ is H; Y is O; and A is —CH₂CH₂—;-   a compound of Formula (I) wherein G is 2-methylcarbonylamino-phenyl;    R³ is H; R⁴ is H; R⁵ is H; Y is O; and A is —CH₂CH₂—;-   a compound of Formula (I) wherein G is pyrrolidin-1-yl; R³ is H; R⁴    is H; R⁵ is H; Y is O; and A is —CH₂CH₂—;-   a compound of Formula (I) wherein G is N,N-diethylaminocarbonyl; R³    is furan-3-yl-methyl; R⁴ is H; R⁵ is H; Y is O; and A is —CH₂CH₂—;

Another embodiment of the present invention is directed to compounds andcompositions comprising a compound selected from the group consistingof:

-   10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic    acid diethylamide;-   (3-Hydroxy-pyrrolidin-1-yl)-[10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-methanone;-   10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic    acid methyl-phenethyl-amide;-   Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine;-   Endo-10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5yl)-10H-phenoxazine;-   Endo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine;-   Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carbonitrile;-   Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-N,N-diethyl-10H-phenoxazine-3-carboxamidine;-   Endo-N,N-Diethyl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxamidine;-   Endo-N,N-Diethyl-10-(8-phenethyl-8-aza-bicyclo[3.2.1    ]oct-3-yl)-10H-phenoxazine-3-carboxamidine;-   Endo-3-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-4H-[1,2,4]oxadiazol-5-one;-   endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic    acid amide;-   Endo-3-[10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-4H-[1,2,4]oxadiazol-5-one;-   Endo-3-[10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-4H-[1,2,4]oxadiazol-5-one;-   10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic    acid diethylamide;-   10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-10H-phenoxazine-3-carboxylic    acid diethylamide;-   6-Methoxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic    acid diethylamide;-   6-Hydroxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic    acid diethylamide;-   6-Methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic    acid diethylamide;-   10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine;-   N,N-Diethyl-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxamidine;-   3-[10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-4H-[1,2,4]oxadiazol-5-one;-   10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenothiazine;-   N-{2-[10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-phenyl}-acetamide;-   10-[8-(3-Methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-3-pyridin-3-yl-10H-phenothiazine;-   3-Pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine;-   10-[8-(3-Methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-3-pyridin-4-yl-10H-phenothiazine;-   3-Pyridin-4-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine;-   3-Pyridin-4-yl-10-(8-thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine;-   N-{2-[10-(8-Allyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-phenyl}-acetamide;-   N-{2-[10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-phenyl}-acetamide;-   N-(2-{10-[8-(1H-Imidazol-2-ylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenothiazin-3-yl}-phenyl)-acetamide;-   N-{2-[10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-phenyl}-acetamide;-   10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenothiazine;-   N-{2-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-phenyl}-acetamide;-   10-(8-Allyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenothiazine;-   Endo-10-(8-Aza-bicyclo[3.2.1    ]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine;-   Endo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine;-   Endo-3-Pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine;-   Endo-10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine;-   Endo-3-Pyridin-3-yl-10-(8-thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine;-   Endo-10-(8-Aza-bicyclo[3.2.1 ]oct-3-yl)-3-chloro-10H-phenoxazine;-   Endo-10-(8-Aza-bicyclo[3.2.1    ]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine;-   Endo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine;-   Endo-3-Pyridin-4-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine;-   Endo-10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine;-   Endo-3-Pyridin-4-yl-10-(8-thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine;-   Exo-3-(3-Pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylic    acid tert-butyl ester;-   Exo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine;-   Exo-3-Pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine;-   Exo-10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine;-   Exo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-chloro-10H-phenoxazine;-   Exo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine;-   Exo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine;-   Exo-3-Pyridin-4-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine;-   Exo-10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine;-   Exo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine;-   Exo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carbonitrile;-   Exo-3-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-4H-[1,2,4]oxadiazol-5-one;-   6-Methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carbonitrile;-   6-Hydroxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carbonitrile;-   [10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1    ]oct-3-yl)-10H-phenothiazin-3-yl]-pyrrolidin-1-yl-methanone;-   [10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-pyrrolidin-1-yl-methanone;-   {10-[8-(3-Methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenothiazin-3-yl}-pyrrolidin-1-yl-methanone;-   [10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl)-10H-hydroxy-pyrrolidin-1-yl)-methanone;-   (3-Hydroxy-pyrrolidin-1-yl)-[10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-methanone;-   {10-[8-(3-Methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenothiazin-3-yl}-(3-methyl-pyrrolidin-1-yl)-methanone;-   [10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-pyrrolidin-1-yl-methanone;-   (3-Hydroxy-pyrrolidin-1-yl)-[10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-methanone;-   10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carboxylic    acid ethylamide;-   Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic    acid diethylamide;-   Endo-10-(8-Thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic    acid diethylamide;-   Endo-10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1    ]oct-3-yl)-10H-phenoxazine-3-carboxylic acid diethylamide;-   Endo-10-(8-Thiazol-2-ylmethyl-8-aza-bicyclo[3.2.1    ]oct-3-yl)-10H-phenoxazine-3-carboxylic acid diethylamide;-   Endo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1    ]oct-3-yl)-10H-phenoxazine-3-carboxylic acid diethylamide;-   Endo-10-(8-Pyridin-3-ylmethyl-8-aza-bicyclo[3.2.1    ]oct-3-yl)-10H-phenoxazine-3-carboxylic acid diethylamide;-   Endo-10-[8-(3-Methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenoxazine-3-carboxylic    acid diethylamide;-   Endo-10-[8-(1H-Imidazol-2-ylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenoxazine-3-carboxylic    acid diethylamide;-   Endo-10-(8-Benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic    acid diethylamide;-   Exo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic    acid diethylamide;-   Exo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic    acid diethylamide;-   Exo-10-(8-Pyridin-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic    acid diethylamide;-   Exo-10-(8-Thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic    acid diethylamide;-   Exo-10-[8-(3-Methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenoxazine-3-carboxylic    acid diethylamide;-   Exo-10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic    acid diethylamide;-   Exo-10-(8-Benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic    acid diethylamide;-   Exo-10-(8-Thiazol-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic    acid diethylamide;-   Exo-10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic    acid diethylamide;-   Exo-10-[8-(1H-Imidazol-2-ylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenoxazine-3-carboxylic    acid diethylamide;-   Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-7-pyridin-3-yl-10H-phenoxazin-4-ol;-   Endo-7-Pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-4-ol;-   Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-chloro-6-methoxy-10H-phenoxazine;-   Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-3-pyridin-3-yl-10H-phenoxazine;-   Endo-6-Methoxy-3-pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine;-   Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-7-pyridin-4-yl-10H-phenoxazin-4-ol;-   Endo-7-Pyridin-4-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-4-ol;-   Endo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-7-pyridin-4-yl-10H-phenoxazin-4-ol;-   Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-3-pyridin-4-yl-10H-phenoxazine;-   Endo-6-Methoxy-3-pyridin-4-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine;-   Endo-6-M    ethoxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine;-   Endo-N-{2-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-phenyl}-acetamide;-   Endo-N-{2-[10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-phenyl}-acetamide;-   Endo-N-{2-[10-(8-Thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-phenyl}-acetamide;-   Endo-N-{2-[10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-phenyl}-acetamide;-   Exo-N-{2-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-phenyl}-acetamide;-   Endo-N-{2-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-hydroxy-10H-phenoxazin-3-yl]-phenyl}-acetamide;-   Endo-N-{2-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-10H-phenoxazin-3-yl]-phenyl}-acetamide;-   10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenothiazine;-   10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenothiazine;-   10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenothiazine;-   N,N-Diethyl-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carboxamidine;-   N,N-Diethyl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carboxamidine;-   10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenothiazine;-   N,N-Diethyl-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carboxamidine;-   10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-3-pyridin-3-yl-10H-phenothiazine;-   10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-7-pyridin-3-yl-10H-phenothiazin-4-ol;-   6-Methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carboxylic    acid diethylamide;-   10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-10H-phenothiazine-3-carboxylic    acid diethylamide;-   10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-hydroxy-10H-phenothiazine-3-carboxylic    acid diethylamide; and-   enantiomers, diastereomers, tautomers, solvates, or pharmaceutically    acceptable salts thereof.

Another embodiment of the present invention is a composition comprisingthe dextrorotatory enantiomer of a compound of formula (I), wherein saidcomposition is substantially free from the levorotatory isomer of saidcompound. In the present context, substantially free means less than25%, preferably less than 10%, more preferably less than 5%, even morepreferably less than 2% and even more preferably less than 1% of thelevorotatory isomer calculated as.

${\% \mspace{14mu} {levorotatory}} = {\frac{\left( {{mass}\mspace{14mu} {levorotatory}} \right)}{\left( {{mass}\mspace{14mu} {dextrorotatory}} \right) + \left( {{mass}\mspace{14mu} {levorotatory}} \right)} \times 100}$

Another embodiment of the present invention is a composition comprisingthe levorotatory enantiomer of a compound of formula (I) wherein saidcomposition is substantially free from the dextrorotatory isomer of saidcompound. In the present context, substantially free from means lessthan 25%, preferably less than 10%, more preferably less than 5%, evenmore preferably less than 2% and even more preferably less than 1% ofthe dextrorotatory isomer calculated as

${\% \mspace{14mu} {dextrorotatory}} = {\frac{\left( {{mass}\mspace{14mu} {dextrorotatory}} \right)}{\left( {{mass}\mspace{14mu} {dextrorotatory}} \right) + \left( {{mass}\mspace{14mu} {levorotatory}} \right)} \times 100}$

In certain embodiments, the present invention provides the endo isomerof a compound of formula (I) wherein said compound is substantially freefrom the exo isomer of said compound. In certain embodiments, thepresent invention provides compositions comprising the endo isomer of acompound of formula (I) wherein said composition is substantially freefrom the exo isomer of said compound. In the present context,substantially free means less than 25%, preferably less than 10%, morepreferably less than 5%, even more preferably less than 2% and even morepreferably less than 1% of the exo isomer.

In certain embodiments, the present invention provides the exo isomer ofa compound of formula (I) wherein said compound is substantially freefrom the endo isomer of said compound. In certain embodiments, thepresent invention provides compositions comprising the exo isomer of acompound of formula (I) wherein said composition is substantially freefrom the endo isomer of said compound. In the present context,substantially free means less than 25%, preferably less than 10%, morepreferably less than 5%, even more preferably less than 2% and even morepreferably less than 1% of the endo isomer.

In other embodiments, compositions of the present invention comprise amixture of the exo and endo isomers of a compound of formula (I).

The compounds of the present invention may also be present in the formof pharmaceutically acceptable salts. For use in medicine, the salts ofthe compounds of this invention refer to non-toxic “pharmaceuticallyacceptable salts” (Ref. International J. Pharm., 1986, 33, 201-217; J.Pharm. Sci., 1997 (January), 66, 1, 1). Other salts well known to thosein the art may, however, be useful in the preparation of compoundsaccording to this invention or of their pharmaceutically acceptablesalts. Representative organic or inorganic acids include, but are notlimited to, hydrochloric, hydrobromic, hydriodic, perchloric, sulfuric,nitric, phosphoric, acetic, propionic, glycolic, lactic, succinic,maleic, fumaric, malic, tartaric, citric, benzoic, mandelic,methanesulfonic, hydroxyethanesulfonic, benzenesulfonic, oxalic, pamoic,2-naphthalenesulfonic, p-toluenesulfonic, cyclohexanesulfamic,salicylic, saccharinic or trifluoroacetic acid. Representative organicor inorganic bases include, but are not limited to, basic or cationicsalts such as benzathine, chloroprocaine, choline, diethanolamine,ethylenediamine, meglumine, procaine, aluminum, calcium, lithium,magnesium, potassium, sodium and zinc.

The present invention includes within its scope prodrugs of thecompounds of this invention. In general, such prodrugs will befunctional derivatives of the compounds that are readily convertible invivo into the required compound. Thus, in the methods of treatment ofthe present invention, the term “administering” shall encompass thetreatment of the various disorders described with the compoundspecifically disclosed or with a compound which may not be specificallydisclosed, but which converts to the specified compound in vivo afteradministration to the patient. Conventional procedures for the selectionand preparation of suitable prodrug derivatives are described, forexample, in “Design of Prodrugs”, ed. H. Bundgaard, Elsevier, 1985.

Where the compounds according to this invention have at least one chiralcenter, they may accordingly exist as enantiomers. Where the compoundspossess two or more chiral centers, they may additionally exist asdiastereomers. It is to be understood that all such isomers and mixturesthereof are encompassed within the scope of the present invention.Furthermore, some of the crystalline forms for the compounds may existas polymorphs and as such are intended to be included in the presentinvention. In addition, some of the compounds may form solvates withwater (i.e., hydrates) or common organic solvents, and such solvates arealso intended to be encompassed within the scope of this invention.

Where the processes for the preparation of the compounds according tothe invention give rise to mixture of stereoisomers, these isomers maybe separated by conventional techniques such as preparativechromatography. The compounds may be prepared in racemic form, orindividual enantiomers may be prepared either by enantiospecificsynthesis or by resolution. The compounds may, for example, be resolvedinto their component enantiomers by standard techniques, such as theformation of diastereomeric pairs by salt formation with an opticallyactive acid, such as (−)-di-p-toluoyl-d-tartaric acid and/or(+)-di-p-toluoyl-1-tartaric acid followed by fractional crystallizationand regeneration of the free base. The compounds may also be resolved byformation of diastereomeric esters or amides, followed bychromatographic separation and removal of the chiral auxiliary.Alternatively, the compounds may be resolved using a chiral HPLC column.

During any of the processes for preparation of the compounds of thepresent invention, it may be necessary and/or desirable to protectsensitive or reactive groups on any of the molecules concerned. This maybe achieved by means of conventional protecting groups, such as thosedescribed in Protective Groups in Organic Chemistry, ed. J. F. W.McOmie, Plenum Press, 1973; and T. W. Greene & P. G. M. Wuts, ProtectiveGroups in Organic Synthesis, John Wiley & Sons, 1991. The protectinggroups may be removed at a convenient subsequent stage using methodsknown from the art.

Even though the compounds of the present invention (including theirpharmaceutically, acceptable salts and pharmaceutically acceptablesolvates) can be administered alone, they will generally be administeredin admixture with a pharmaceutical carrier, excipient or diluentselected with regard to the intended route of administration andstandard pharmaceutical or veterinary practice. Thus, the presentinvention is directed to pharmaceutical and veterinary compositionscomprising compounds of Formula (I) and one or more pharmaceuticallyacceptable carriers, excipients or diluents.

By way of example, in the pharmaceutical and veterinary compositions ofthe present invention, the compounds of the present invention may beadmixed with any suitable binder(s), lubricant(s), suspending agent(s),coating agent(s), and/or solubilising agent(s).

Tablets or capsules of the compounds may be administered singly or twoor more at a time, as appropriate. It is also possible to administer thecompounds in sustained release formulations.

Alternatively, the compounds of the general Formula (I) can beadministered by inhalation or in the form of a suppository or pessary,or they may be applied topically in the form of a lotion, solution,cream, ointment or dusting powder. An alternative means of transdermaladministration is by use of a skin patch. For example, they can beincorporated into a cream consisting of an aqueous emulsion ofpolyethylene glycols or liquid paraffin. They can also be incorporated,at a concentration of between 1 and 10% by weight, into an ointmentconsisting of a white wax or white soft paraffin base together with suchstabilizers and preservatives as may be required.

For some applications, preferably the compositions are administeredorally in the form of tablets containing excipients such as starch orlactose, or in capsules or ovules either alone or in admixture withexcipients, or in the form of elixirs, solutions or suspensionscontaining flavoring or coloring agents.

The compositions (as well as the compounds alone) can also be injectedparenterally, for example intracavernosally, intravenously,intramuscularly or subcutaneously. In this case, the compositions willcomprise a suitable carrier or diluent.

For parenteral administration, the compositions are best used in theform of a sterile aqueous solution which may contain other substances,for example enough salts or monosaccharides to make the solutionisotonic with blood.

For buccal or sublingual administration the compositions may beadministered in the form of tablets or lozenges which can be formulatedin a conventional manner.

By way of further example, pharmaceutical and veterinary compositionscontaining one or more of the compounds of the invention describedherein as the active ingredient can be prepared by intimately mixing thecompound or compounds with a pharmaceutical carrier according toconventional pharmaceutical compounding techniques. The carrier may takea wide variety of forms depending upon the desired route ofadministration (e.g., oral, parenteral). Thus for liquid oralpreparations such as suspensions, elixirs and solutions, suitablecarriers and additives include water, glycols, oils, alcohols, flavoringagents, preservatives, stabilizers, coloring agents and the like; forsolid oral preparations, such as powders, capsules and tablets, suitablecarriers and additives include starches, sugars, diluents, granulatingagents, lubricants, binders, disintegrating agents and the like. Solidoral preparations may also be coated with substances such as sugars orbe enteric-coated so as to modulate the major site of absorption. Forparenteral administration, the carrier will usually consist of sterilewater and other ingredients may be added to increase solubility orpreservation. Injectable suspensions or solutions may also be preparedutilizing aqueous carriers along with appropriate additives.

Advantageously, compounds of the present invention may be administeredin a single daily dose, or the total daily dosage may be administered individed doses of two, three or four times daily. Furthermore, compoundsfor the present invention can be administered in intranasal form viatopical use of suitable intranasal vehicles, or via transdermal skinpatches well known to those skilled in that art. To be administered inthe form of a transdermal delivery system, the dosage administrationwill, of course, be continuous rather than intermittent throughout thedosage regimen.

It is also apparent to one skilled in the art that the therapeuticallyeffective dose for active compounds of the invention or a pharmaceuticalcomposition thereof will vary according to the desired effect.Therefore, optimal dosages to be administered may be readily determinedand will vary with the particular compound used, the mode ofadministration, the strength of the preparation, and the advancement ofthe disease condition. In addition, factors associated with theparticular subject being treated, including subject age, weight, dietand time of administration, will result in the need to adjust the doseto an appropriate therapeutic level. The above dosages are thusexemplary of the average case. There can, of course, be individualinstances where higher or lower dosage ranges are merited, and such arewithin the scope of this invention.

Compounds of this invention may be administered in any of the foregoingcompositions and dosage regimens or by means of those compositions anddosage regimens established in the art whenever use of the compounds ofthe invention as analgesics is required for a subject in need thereof.

The invention also provides a pharmaceutical or veterinary pack or kitcomprising one or more containers filled with one or more of theingredients of the pharmaceutical and veterinary compositions of theinvention. Optionally associated with such container(s) can be a noticein the form prescribed by a governmental agency regulating themanufacture, use or sale of pharmaceuticals or biological products,which notice reflects approval by the agency of manufacture, use or salefor human administration.

The compounds of the present invention may be used to treat mild tosevere pain in warm-blooded animals such as humans by administration ofan analgesically effective dose. The dosage range would be from about0.1 mg to about 15,000 mg, in particular from about 50 mg to about 3500mg or, more particularly from about 100 mg to about 1000 mg of activeingredient in a regimen of about 1 to 4 times per day for an average (70kg) human; although, it is apparent to one skilled in the art that thetherapeutically effective amount for active compounds of the inventionwill vary as will the types of pain being treated.

For oral administration, a pharmaceutical composition is preferablyprovided in the form of tablets containing 0.01, 10.0, 50.0, 100, 150,200, 250, and 500 milligrams of the active ingredient for thesymptomatic adjustment of the dosage to the subject to be treated.

Examples of pain intended to be within the scope of the presentinvention include, but are not limited to, inflammatory pain, centrallymediated pain, peripherally mediated pain, visceral pain, structural orsoft tissue injury related pain, progressive disease related pain,neuropathic pain and acute pain such as caused by acute injury, traumaor surgery and chronic pain such as headache and that caused byneuropathic conditions, post-stroke conditions, cancer, and migraine.

Compounds of the present invention are also useful asimmunosuppressants, antiinflammatory agents, agents for the treatmentand prevention of neurological and psychiatric conditions, for instance,depression and Parkinson's disease, agents for the treatment ofurological and reproductive conditions, for instance, urinaryincontinence and premature ejaculation, medicaments for drug and alcoholabuse, agents for treating gastritis and diarrhea, cardiovascular agentsand cardioprotective agents and agents for the treatment of respiratorydiseases.

The compounds of the present invention are also useful in treating paincaused by osteoarthritis, rheumatoid arthritis, fibromyalgia, migraine,headache, toothache, burn, sunburn, snake bite (in particular, venomoussnake bite), spider bite, insect sting, neurogenic bladder, benignprostatic hypertrophy, interstitial cystitis, rhinitis, contactdermatitis/hypersensitivity, itch, eczema, pharyngitis, mucositis,enteritis, cellulites, causalgia, sciatic neuritis, mandibular jointneuralgia, peripheral neuritis, polyneuritis, stump pain, phantom limbpain, post-operative ileus, cholecystitis, postmastectomy pain syndrome,oral neuropathic pain, Charcot's pain, reflex sympathetic dystrophy,Guillain-Barre syndrome, meralgia paresthetica, burning-mouth syndrome,post-herpetic neuralgia, trigeminal neuralgia, cluster headache,migraine headache, peripheral neuropathy, bilateral peripheralneuropathy, diabetic neuropathy, postherpetic neuralgia, trigeminalneuralgia, optic neuritis, postfebrile neuritis, migrating neuritis,segmental neuritis, Gombault's neuritis, neuronitis, cervicobrachialneuralgia, cranial neuralgia, geniculate neuralgia, glossopharyngialneuralgia, migrainous neuralgia, idiopathic neuralgia, intercostalsneuralgia, mammary neuralgia, Morton's neuralgia, nasociliary neuralgia,occipital neuralgia, red neuralgia, Sluder's neuralgia, splenopalatineneuralgia, supraorbital neuralgia, vidian neuralgia, inflammatory boweldisease, irritable bowel syndrome, sinus headache, tension headache,labor, childbirth, menstrual cramps, and cancer.

In regard to the use of the present compounds in treatment of thediseases or conditions such as those listed above, a therapeuticallyeffective dose can be determined by persons skilled in the art by theuse of established animal models. Such a dose would likely fall in therange of from about 0.01 mg to about 15,000 mg of active ingredientadministered 1 to 4 times per day for an average (70 kg) human.

General Synthetic Methods

Representative compounds of the present invention can be synthesized inaccordance with the general synthetic methods described below and areillustrated in the schemes that follow. Since the schemes are anillustration, the invention should not be construed as being limited bythe chemical reactions and conditions expressed. The preparation of thevarious starting materials used in the schemes is well within the skillof persons versed in the art.

The preparation of compounds of this invention is illustrated in Schemes1 through 11. The overall strategy in Scheme 1 is based on the synthesisof appropriately substituted compounds of formula 1.4 (Y═O, S) that arecondensed with an appropriately substituted compound of formula 1.5. Incompounds of formula 1.5, X₂ and X₃ can each be a halogen atom,trifluoromethanesulfonyloxy or a nitro group. In stage 1.1, a bridgedN1-protected 4-aminopiperidine 1.1 is condensed with a properlysubstituted O-protected phenol (Y═O) or thiophenol (Y═S) 1.2. Theprotective group on the N1 nitrogen of 1.1 (represented as P) mayinclude an alkanyl, alkenyl or aralkanyl group in which case they arethe therapeutically useful products of this invention. The group P mayalso be trifluoromethylcarbonyl, alkoxycarbonyl or aralkoxycarbonyl.Bridge A may include (CH₂)₂ and (CH₂)₃. Useful phenol or thiophenolprotective groups (R) include lower alkyl groups, benzyl, trialkylsilyland the like. Appropriate substituents on the protected phenol orthiophenol in the 2-position (X₁) may include halogens andtrifluoromethanesulfonyloxy. The Q group in the 5-position may be asubstituent such as fluoro, chloro, bromo, cyano, iodo, carboxy,dialkylaminosulfonyl or trifluoromethanesulfonyloxy. Stage 1.2 includesdeprotection of the phenol or thiophenol protective group. Suchtransformations may include the dealkylation of lower alkyl ethers togive their corresponding alcohols using reagents such as borontrihalides, or dealkylation of lower alkyl thioethers using reagentssuch as Na/NH₃. A benzyl protective group may be removed underconditions of hydrogenation in the presence of a transition metal suchas palladium. Trialkylsilyl protective groups may be removed bytreatment with a source of fluoride anion such as tetrabutyl ammoniumfluoride, or by exposure to an inorganic acid such as aqueous hydrogenchloride and the like.

In stage 1.3, hydroxyaniline (Y═O) or thioaniline (Y═S) 1.4 may becondensed with an appropriately substituted benzene moiety 1.5.Substituents X₂ and X₃ may include halogens,trifluoromethanesulfonyloxy, or a nitro group. Useful couplingconditions of the anilino nitrogen with a compound of formula 1.5include palladium catalyzed condensations in the presence of a phosphineligand such as Pd₂(dba)₃ and a base such as cesium carbonate. Couplingof the hydroxy or thio moiety with the remaining substituted phenylgroup may proceed using Ullmann type coupling conditions. In addition,the two steps described in stage 1.3 may be reversed with biaryl etheror biaryl thioether formation preceding the formation of the biarylamine. Alternatively, the condensation between compounds of formula 1.4and compounds of formula 1.5 to yield compounds of formula 1.6 in onestep may be affected by treatment with an inorganic base such aspotassium carbonate in a suitable solvent such as dimethyl formamide.

The regiochemical outcome of the condensation between compounds offormula 1.4 and compounds of formula 1.5 depends on the position of theR4 substituent in compounds of formula 1.5 and on the reactionconditions used for the condensation. An extensive review on this topicis available in the literature (see, for example: The Smiles and RelatedRearrangements of aromatic Systems' by W. E. Truce, E. M. Kreider, andW. W. Brand in Organic Reactions, 1970, Vol. 18, pp. 99-215).

The protective group P can be removed to obtain secondary amines 1 asillustrated for Stage 1.4. These transformations may be carried outusing certain acidic reagents such as hydrogen bromide or trimethylsilyliodide. Phenoxazines (Y═O) or phenothiazines (Y═S) of type 1.6 bearingreadily cleavable groups such as methyl, allyl or benzyl may betransformed into the aforementioned alkoxycarbonyl derivatives bytreatment with alkanylchloroformates such as ethyl chloroformate or1-chloroethyl chloroformate and thus serve as sources of phenoxazinesand phenothiazines 1. Phenoxazines or phenothiazines of type 1.6 bearinga trifluormethylcarbonyl group may be treated with potassium carbonatein an alcoholic solvent such as methanol to yield phenoxazines andphenothiazines 1.

Finally the secondary amines 1 may be converted to a compound of formula2 as shown in Stage 1.5. These transformations may be carried out byreductive alkylation using a carbonyl compound and a reducing agent suchas sodium borohydride, sodium cyanoborohydride, sodiumtriacetoxyborohydride, or tetramethylammonium triacetoxyborohydride.They may also be carried out by alkylation using an alkanyl, alkenyl oraralkyl halide and an organic or inorganic base.

The Q function in compounds 1 or 2 may be converted into group G, whichmay be —C(Z)NR₁ R₂, an aryl substituent, or an appropriate heterocycleas defined herein, to give compounds of formula I. When the Q functionis a halogen or trifluoromethanesulfonyloxy, it may be converted to anester via alkoxycarbonylation using carbon monoxide, an aliphaticalcohol, a trialkanyl amine, and a palladium catalyst such asbis(triphenylphosphine) palladium(II)dichloride. Subsequently, when Q isan ester, the ester may be hydrolyzed to a carboxylic acid. Thecarboxylic acid may then be coupled with ammonia, a primary amine, or asecondary amine to form a primary, secondary or tertiary amide,respectively. Alternatively, the conversion of a carboxylic acid to anamide may be carried out via an acid chloride using thionyl chloride,oxalyl chloride, or the like, followed by a Schotten-Baumann reactionusing ammonia or an amine in the presence of an alkali metal hydroxide.Alternatively, the conversion of a carboxylic acid to an amide may becarried out via the use of peptide coupling agents such as1,3-dicyclohexylcarbondiimide (DCC),O-(7-azabenzotriazol-1-yl)-N,N,N′N′-tetramethyluroniumhexafluorophosphate (HATU),O-benzotriazol-1-yl-N,N,N′,N′-tetramethyluronium hexafluorophosphate(HBTU), or the like. Alternatively, the ester may be converted directlyto the amide by the action of a dimethylaluminum amide.

Alternatively, when the Q function is a halogen ortrifluoromethanesulfonyloxy, it may be converted directly to an amidevia aminocarbonylation using a carbon monoxide source such as molybdenumhexacarbonyl, an appropriate amine, and a palladium catalyst such asHermann's catalyst.

Alternatively, one may effect the transformation of the group Q to asubstituent G (wherein G is an amidino or heterocycle) by way of anitrile. Synthesis of the nitrile may be accomplished by treatment ofthe compounds 1 or 2 (when Q is bromo or trifluoromethanesulfonyloxy)with Zn(CN)₂ and a palladium catalyst such as (Ph₃P)₄Pd or by treatmentof the compounds 1 or 2 with CuCN at elevated temperatures. For thesynthesis of amidino functional groups, the nitrile is treated withhydroxylamine under basic conditions to afford an oxime. Treatment ofthe oxime with a primary or secondary amine, CuCl, and an alkali metalcarbonate under microwave irradiation in an alcoholic solvent providesthe amidino compounds of the present invention. Microwave acceleratedreactions may be performed using either a CEM Discover or a PersonalChemistry Smith Synthesizer microwave instrument. The oxime describedabove is instrumental in the preparation of compounds wherein G is aheterocycle. The oxime may be cyclized with a variety of electrophilesknown to one versed in the art to give the heterocycles of the presentinvention. For instance, reaction of an oxime with CDI providesoxadiazolones, and treatment of the oxime with TCDI provides thecorresponding oxadiazolethiones. Similarly, the treatment of the oximewith thionyl chloride in the presence of a tertiary amine givesoxathiadiazoles of the present invention.

Alternatively, compounds where Q is a halogen atom or atrifluoromethanesulfonyloxy group may participate in transitionmetal-mediated coupling reactions such as Suzuki, Stille or Negishichemistry. Desired end products of the present invention may includechemical modifications at R₄. Such transformations may include thedealkylation of lower alkyl ethers to give the corresponding alcoholsusing reagents such as boron trihalides. Compounds where R₄ is a halogenatom may participate in transition metal-mediated coupling reactionssuch as Suzuki, Stille or Negishi chemistry.

Scheme 2 outlines an alternative approach to the synthesis ofphenoxazines (Y═O) or phenothiazines (Y═S) 1.6. In this scheme, anappropriately substituted phenol (Y═O) or thiophenol (Y═S) of type 2.2is reacted with an appropriately substituted benzene moiety 2.1 in thepresence of a base, such as potassium carbonate or sodium hydroxide inan organic solvent, such as dimethyl formamide, dimethyl acetamide,dimethyl sulfoxide or the like as shown in stage 2.1. Appropriatesubstituents X₁ and X₂ in this scheme may include halogens andtrifluoromethanesulfonyloxy. In stage 2.2, the nitro functionality isreduced to the corresponding amine. This reduction can be accomplishedvia treatment with tin(II) chloride in an alcoholic solvent such asethanol. Stage 2.3 depicts the conversion of primary aniline 2.4 tosecondary aniline 2.6, which can be accomplished via reductivealkylation using a carbonyl compound 2.5 and a reducing agent such assodium borohydride, sodium cyanoborohydride, sodiumtriacetoxyborohydride, or tetramethylammonium triacetoxyborohydride.Stage 2.4 depicts formation of compounds of formula 1.6, which can beaccomplished by treatment of secondary aniline 2.6 with an appropriatebase such as potassium carbonate.

Scheme 3 illustrates an alternative synthesis of compound 2.3. In thisapproach, an appropriately substituted 2-nitrophenol (Y═O) or2-nitrothiophenol (Y═S) may be condensed with an appropriatelysubstituted benzene moiety of type 3.2 under Ullmann type couplingconditions. Appropriate substituents X₁ and X₂ include halogens andtrifluoromethanesulfonyloxy.

Scheme 4 illustrates an alternative approach to the synthesis ofphenoxazines (Y═O) or phenothiazines (Y═S) 1.6. Condensation ofappropriately substituted phenols (Y═O) or thiophenols (Y═S) 2.2 withsubstituted benzene moiety 1.5 under Ullmann type coupling conditions asshown in stage 4.1 may result in the formation of biaryl ethers (Y═O) orbiaryl thioethers (Y═S) 4.1. Appropriate X₁, X₂ and X₃ substituents mayinclude halogens and trifluoromethanesulfonyloxy. Palladium catalyzedcondensation of biaryl ethers or biaryl thioethers 4.1 with bridgedN1-protected 4-aminopiperidines 1.1 in the presence of a phosphineligand such as Pd₂(dba)₃ and a base such as cesium carbonate is shown instage 4.2 may result in the formation of phenoxazines or phenothiazines1.6.

An alternative approach to the synthesis of intermediate 4.1 is depictedin Scheme 5 and is based on the reaction of appropriately substitutedphenols (Y═O) or thiophenols (Y═S) 5.1 with an appropriately substitutedbenzene moiety 3.2 under Ullmann type coupling conditions (stage 5.1).Substituents X₁, X₂, and X₃ may include halogens ortrifluoromethanesulfonyloxy.

Scheme 6 illustrates an alternative approach to the synthesis ofintermediates 2.6. An appropriately substituted compound of formula 1.5may be reacted with bridged N1-protected 4-aminopiperidines 1.1 in thepresence of a palladium catalyst such as Pd₂(dba)₃, a phosphine ligandand a base such as cesium carbonate as shown in stage 6.1. AppropriateX₁ and X₂ substituents may include halogens andtrifluoromethanesulfonyloxy. Compounds of formula 6.1 may then bereacted with appropriately substituted phenols (Y═O) or thiophenols(Y═S) 2.2 under Ullmann type coupling conditions to yield anilines 2.6as shown in stage 6.2.

Scheme 7 illustrates an alternative approach to the synthesis ofphenoxazines (Y═O) or phenothiazines (Y═S) 1.6. Condensation ofappropriately substituted compounds of formula 3.2 with bridgedN1-protected 4-aminopiperidines 1.1 may result in formation ofintermediate 7.1 as shown in stage 7.1. Appropriate X₁, X₂, and X₃substituents may include halogens and trifluoromethanesulfonyloxy.Reaction of compounds 7.1 with appropriately substituted phenol (Y═O) orthiophenols (Y═S) 7.2 under Ullmann like coupling conditions may resultin formation of compounds 7.3 as shown in stage 7.2. Finally, ringclosure of compounds 7.4 may be accomplished in the presence of apalladium catalyst such as Pd₂(dba)₃, a phosphine ligand such as4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (xant phos) and a basesuch as potassium tert-butoxide or cesium carbonate as shown in stage7.3.

Scheme 8 illustrates an alternative synthesis of phenoxazines (Y═O) orphenothiazines (Y═S) 1.6 and is based on an Ullmann-like coupling ofbridged N1-protected 4-aminopiperidines 1.1 with appropriatelysubstituted and protected phenols (Y═O) or thiophenols (Y═S) 8.1 asshown in stage 8.1. Useful phenol or thiophenol protective groups forcompounds 8.1 include lower alkyl groups, benzyl, trialkylsilyl and thelike. Appropriate X₁, X₂, and X₃ substituents may include halogens andtrifluoromethanesulfonyloxy. The resulting compounds 8.2 may becondensed with appropriately functionalized benzene compounds 3.2 toyield diarylanilines 8.3. Stage 8.3 includes deprotection of the phenolor thiophenol protective group. Such transformations may include thedealkylation of lower alkyl ethers to give their corresponding alcoholsusing reagents such as boron trihalides or the dealkylation of the alkylthioethers using Na/NH₃. A benzyl protective group may be removed underconditions of hydrogenation in the presence of a transition metal suchas palladium. Trialkylsilyl protective groups may be removed bytreatment with a source of fluoride anion such as tetrabutyl ammoniumfluoride, or by exposure to an inorganic acid such as aqueous hydrogenchloride and the like. Finally, ring closure of compounds 8.3 tophenoxazines or phenothiazines 1.6 may be accomplished via an Ullmanntype transformation as shown in stage 8.4.

Scheme 9 illustrates another synthetic approach to compounds 7.4.Displacement of X₁ in appropriately substituted compounds of formula 9.2with appropriately substituted compounds of formula 9.1 as shown instage 9.1 may lead to biaryl ethers (Y═O) and biarylthioethers (Y═S)9.3. Appropriate X₁ and X₂ substituents may include halogens andtrifluoromethanesulfonyloxy. Reduction of compounds 9.3 to amines 9.4 asshown in stage 9.2 may be accomplished using tin(II) chloride in analcoholic solvent such as ethanol. Stage 9.3 depicts the conversion ofprimary anilines 9.4 to secondary anilines 7.4 and can be accomplishedvia reductive alkylation using a carbonyl compounds 2.5 and a reducingagent such as sodium borohydride, sodium cyanoborohydride, sodiumtriacetoxyborohydride, or tetramethylammonium triacetoxyborohydride.

Scheme 10 illustrates another synthetic approach to compounds 9.3. Forconstruction of diaryl ethers (Y═O) and diaryl thioethers (Y═S) 9.3,appropriately substituted 2-hydroxynitrobenzenes or 2-thionitrobenzenes10.1 may be caused to react with appropriately substituted compounds offormula 1.5 under Ullmann type conditions as shown in stage 10.1.Appropriate X₂ and X₃ substituents may include halogens andtrifluoromethanesulfonyloxy.

Scheme 11 illustrates another synthetic approach to compounds 1.6. Stage11.1 depicts the conversion of appropriately substituted2-hydroxyanilines (Y═O) 11.1 to compounds 11.2 (Y═O), which can beaccomplished via reductive alkylation using a carbonyl compound 2.5 anda reducing agent such as sodium borohydride, sodium cyanoborohydride,sodium triacetoxyborohydride, or tetramethylammoniumtriacetoxyborohydride. Appropriately substituted 2-hydroxyanilines 11.2may be caused to react with an appropriately substituted benzene 3.2under Ullmann type conditions or under basic conditions such aspotassium carbonate in DMF (when X₁═NO₂) as shown in stage 11.3 to yieldcompounds of formula 1.6. Appropriate X₁ and X₂ substituents may includehalogens, trifluoromethanesulfonyloxy, and a nitro group.

The regiochemical outcome of the condensation of compounds of formula11.2 with compounds of formula 3.2 depends on the position of the Qsubstituent in compounds of formula 3.2 and on the reaction conditionsused for the condensation. An extensive review on this topic isavailable in the literature (see, for example: The Smiles and RelatedRearrangements of aromatic Systems' by W. E. Truce, E. M. Kreider, andW. W. Brand in Organic Reactions, 1970, Vol. 18, pp. 99-215).

In compounds of formula 11.1 where Y is sulfur, an intermediate spirocompound of formula 11.3 may be formed. Compounds of formula 11.3 may beconverted to compounds of formula 11.2 (Y═S) by treatment with a hydridereagent such as lithium aluminum hydride or sodium borohydride.

In the above Schemes 1 through 11, the Q function of compounds 2 may beconverted into group G, which may be —C(Z)NR₁ R₂, an aryl substituent,or an appropriate heterocycle as defined herein, to give compounds offormula 3. When the Q function of compounds 2 is a halogen ortrifluoromethanesulfonyloxy, it may be converted to an ester viaalkoxycarbonylation using carbon monoxide, an aliphatic alcohol, atrialkanyl amine, and a palladium catalyst such asbis(triphenylphosphine) palladium(I1)dichloride. Subsequently, when Q isan ester, the ester may be hydrolyzed to a carboxylic acid. Thecarboxylic acid may then be coupled with ammonia, a primary amine, or asecondary amine to form a primary, secondary or tertiary amide,respectively. Alternatively, the conversion of a carboxylic acid to anamide may be carried out via an acid chloride using thionyl chloride,oxalyl chloride, or the like, followed by a Schotten-Baumann reactionusing ammonia or an amine in the presence of an alkali metal hydroxide.Alternatively, the conversion of a carboxylic acid to an amide may becarried out via the use of peptide coupling agents such as1,3-dicyclohexylcarbondiimide (DCC),O-(7-azabenzotriazol-1-yl)-N,N,N′N′-tetramethyluroniumhexafluorophosphate (HATU),O-benzotriazol-1-yl-N,N,N′,N′-tetramethyluronium hexafluorophosphate(HBTU), or the like. Alternatively, the ester may be converted directlyto the amide by the action of a dimethylaluminum amide.

Instead of proceeding to compounds 3 via an ester, one may effect thetransformation of the group Q to a substituent G (wherein G is anamidino or heterocycle) by way of a nitrile. Synthesis of the nitrilemay be accomplished by treatment of the compounds 2 (when Q is bromo ortrifluoromethanesulfonyloxy) with Zn(CN)₂ and a palladium catalyst suchas (Ph₃P)₄Pd or by treatment of the compounds 2 with CuCN at elevatedtemperatures. For the synthesis of amidino functional groups, thenitrile is treated with hydroxylamine under basic conditions to affordan oxime. Treatment of the oxime with a primary or secondary amine,CuCl, and an alkali metal carbonate under microwave irradiation in analcoholic solvent provides the amidino compounds of the presentinvention. Microwave accelerated reactions may be performed using eithera CEM Discover or a Personal Chemistry Smith Synthesizer microwaveinstrument. The oxime described above is instrumental in the preparationof compounds wherein G is a heterocycle. The oxime may be cyclized witha variety of electrophiles known to one versed in the art to give theheterocycles of the present invention. For instance, reaction of anoxime with CDI provides oxadiazolones, and treatment of the oxime withTCDI provides the corresponding oxadiazolethiones. Similarly, thetreatment of the oxime with thionyl chloride in the presence of atertiary amine gives oxathiadiazoles of the present invention.

An aryl substituent may be installed in place of the functional group Qby coupling compounds 2 (when Q is bromo or trifluoromethanesulfonyloxy)with a suitably substituted arylboronic acid in the presence of apalladium catalyst and an alkali metal carbonate.

Desired end products of the present invention may include chemicalmodifications at R₄. Such transformations may include the dealkylationof lower alkyl ethers to give their corresponding alcohols, usingreagents such as boron trihalides. Compounds where R₄ is a halogen atommay participate in transition metal-mediated coupling reactions such asSuzuki, Stille or Negishi chemistry.

It is generally preferred that the respective product of each processstep be separated from other components of the reaction mixture andsubjected to purification before its use as a starting material in asubsequent step. Separation techniques typically include evaporation,extraction, precipitation and filtration. Purification techniquestypically include column chromatography (Still, W. C. et. al., J. Org.Chem. 1978, 43, 2921), thin-layer chromatography, crystallization anddistillation. The structures of the final products, intermediates andstarting materials are confirmed by spectroscopic, spectrometric andanalytical methods including nuclear magnetic resonance (NMR), massspectrometry (MS) and liquid chromatography (HPLC). In the descriptionsfor the preparation of compounds of this invention, ethyl ether,tetrahydrofuran and dioxane are common examples of an ethereal solvent;benzene, toluene, hexanes and heptanes are typical hydrocarbon solventsand dichloromethane and dichloroethane are representative halogenatedhydrocarbon solvents. In those cases where the product is isolated asthe acid addition salt the free base may be obtained by techniques knownto those skilled in the art. In those cases in which the product isisolated as an acid addition salt, the salt may contain one or moreequivalents of the acid. Enantiomers of the compounds of the presentinvention may be separated using chiral HPLC.

Representative compounds of the present invention can be synthesized inaccordance with the general synthetic methods described above and areillustrated more particularly in the schemes that follow. Since theschemes are illustrations, the invention should not be construed asbeing limited by the chemical reactions and conditions expressed. Thepreparation of the various starting materials used in the schemes iswell within the skill of persons versed in the art.

ABBREVIATIONS

-   AcOH=acetic acid-   Boc=tert-butoxycarbonyl-   DIEA=N,N-diisopropyl-N-ethylamine-   DMF=N,N-dimethylformamide-   DMSO=dimethyl sulfoxide-   Et=ethyl-   h=hour(s)-   HBTU=O-benzotriazol-1-yl-N,N,N′,N′-tetramethyluronium    hexafluorophosphate-   K₂CO₃=potassium carbonate-   Me=methyl-   min=minute(s)-   rt=room temperature-   xantphos=4,5-bis(diphenylphosphino)-9,9-dimethylxanthene

Although the foregoing invention has been described in detail by way ofexample for purposes of clarity of understanding, it will be apparent tothe artisan that certain changes and modifications are comprehended bythe disclosure and can be practiced without undue experimentation withinthe scope of the appended claims, which are presented by way ofillustration not limitation.

All publications and patent documents cited above are herebyincorporated by reference in their entirety for all purposes to the sameextent as if each were so individually denoted.

Examples Example A

Procedure 13-Hydroxy-4-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-benzoic acidmethyl ester, 1a

To a solution of 4-amino-3-hydroxybenzoic acid methyl ester (2.0 g; 12mmol) and 8-methyl-8-aza-bicyclo[3.2.1]octan-3-one (1.1 g; 10.8 mmol) indichloroethane (30 mL) was added sodium triacetoxyborohydride (3.2 g;15.1 mmol) and acetic acid (0.65 mL; 11.4 mmol). The mixture was stirredat rt for 16 h. The mixture was diluted with 1N NaHCO₃ solution andchloroform was added. The organic layer separated, and the aqueous phasewas lyophilized. The lyophilized residue was purified via reverse phaseHPLC (eluent gradient: 10 to 50% acetonitrile in water containing 0.1%TFA) to yield 1.61 g (36.9%) of a mixture of endo and exo isomers of3-hydroxy-4-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-benzoic acidmethyl ester, 1a as a TFA salt. MS m/z (MH⁺) 291.

Procedure 210-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid methyl ester, 2a

A mixture of the TFA salt of3-hydroxy-4-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-benzoic acidmethyl ester, 1a (0.424 g, 0.734 mmol), 2-fluoronitrobenzene (95 μL, 0.9mmol) and potassium carbonate (564 mg, 4 mmol) in DMF was heated toreflux for 70 min. The mixture was allowed to cool to rt, filtered, andpurified via reverse phase HPLC to yield 440 mg (88%) of10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid methyl ester, 2a, as TFA salt. MS m/z (MH⁺) 365.1.

Procedure 3 10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic acid, 3a

To a solution of10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid methyl ester, 2a (440 mg, 0.646 mmol) in THF (5 mL) was added 1NNaOH (5 mL), and the mixture was stirred for 3 hr at rt. The solvent wasremoved, the residue was dissolved in DMF and acidified with a 2N TFAsolution, and purified via reverse phase HPLC to yield 295 mg (63%) of10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid, 3a, as a TFA salt. MS m/z (MH⁺) 351.1.

Procedure 4 10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic acid diethylamide, 4a

To a solution of the TFA salt of10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid 3a (65 mg, 0.14 mmol) and HBTU (64 mg; 0.17 mmol) in DMF (2 mL) wasadded triethylamine (69 μL, 0.43 mmol). The mixture was stirred for 1 hrat rt, and purified without prior quenching via reverse phase HPLC(eluent gradient: acetonitrile in water containing 0.1% TFA) to yield44.4 mg (61%) of title compound10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 4a as a TFA salt. MS m/z (MH⁺) 406.2.

(3-Hydroxy-pyrrolidin-1-yl)-[10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-methanone,5a

Using an adaptation of Procedure 4, and substituting3-hydroxypyrrolidine for diethylamine, the title compound(3-hydroxy-pyrrolidin-1-yl)-[10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-methanone,5a was obtained as a TFA salt. MS m/z (MH⁺) 420.1.

10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid methyl-phenethyl-amide

Using an adaptation of Procedure 4, and substitutingN-methyl-N-phenethylamine for diethylamine, the title compound10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid methyl-phenethyl-amide, 6a was obtained as a TFA salt. MS m/z (MH⁺)468.3.

Example B

Procedure 5Endo-3-(2-Hydroxy-phenylamino)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1b andExo-3-(2-Hydroxy-phenylamino)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2b

To a solution of 2-aminophenol (5.0 g; 45.82 mmol) and3-oxo-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester(15.5 g; 68.8 mmol) in dichloroethane (200 mL) was added acetic acid(2.62 mL; 45.77 mmol). The mixture was stirred at rt for 1 h and sodiumtriacetoxyborohydride (11.6 g; 54.73 mmol) was added in small portions.The mixture was stirred at rt for 16 h and treated with H₂O (200 mL).The organic layer was separated, dried over MgSO₄, filtered, andevaporated. The residue was purified via column chromatography (eluentgradient: 10 to 30% ethyl acetate in heptane) to yield 8 g (55%) ofendo-3-(2-hydroxy-phenylamino)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1b and 1.5 g (10%) ofexo-3-(2-hydroxy-phenylamino)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1b. MS m/z (MH⁺) 318.9.

Procedure 6Endo-3-(3-Cyano-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3b

To a solution of 4-fluoro-3-nitrobenzonitrile (0.29 g; 1.74 mmol) andendo-3-(2-hydroxy-phenylamino)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1b (0.55 g; 1.73 mmol) in DMF (6 mL) was addedpotassium carbonate (0.48 g; 3.47 mmol). The mixture was stirred at 170°C. for 30 min. The mixture was allowed to cool to rt and poured intoice-water 910 mL). The solid was separated via filtration, washed withwater, and dried to yield 0.63 g (86%) ofendo-3-(3-cyano-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3b. MS m/z (MH⁺) 417.9.The material was used assuch for the next reaction.

Procedure 7Endo-3-[3-(1H-Tetrazol-5-yl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 4b

To a solution ofendo-3-(3-cyano-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3b (1 g; 2.4 mmol) in DMF (20 mL) were addedsodium azide (0.47 g, 7.23 mmol) and ammonium chloride (0.39 g; 7.29mmol), and the mixture was heated at 120° C. for 16 h. The mixture wasallowed to cool to rt, and filtered. The filtrate was acidified with 1Nhydrochloric acid (10 mL) and extracted with ethyl acetate (3×10 mL).The combined organic layers were dried over MgSO₄, filtered, andevaporated. The residue was used as such for the next reaction.

Procedure 8Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b

To a solution ofendo-3-[3-(1H-tetrazol-5-yl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]-octane-8-carboxylicacid tert-butyl ester, 4b (2.4 mmol) in dioxane (5 mL) was added a 4Nhydrochloric acid solution (5 mL). The mixture was stirred at rt for 16h. The mixture was filtered, and the filtrate was evaporated. Theresidue was purified via reverse phase chromatography (eluent gradient:acetonitrile in water containing 0.1% TFA) to yieldcrudeendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b as a TFA salt. MS m/z (MH⁺) 360.9. The material was used as such inthe next reaction.

Procedure 9Endo-10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,6b

To a suspension of the HCl salt ofendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b (0.2 g; 0.5 mmol) and 2-pyridylcarboxaldehyde (0.071 mL; 0.74 mmol)in dichloroethane (4 mL) was added sodium triacetoxyborohydride (0.13 g;0.61 mmol). The mixture was stirred at rt for 15 h and a saturatedNaHCO₃ solution (3 mL). The organic layer was separated, and the aqueousphase was extracted with ethyl acetate (5 mL). The combined organiclayers were dried over MgSO₄, filtered, and evaporated. The residue waspurified via reverse phase HPLC (eluent: acetonitrile in watercontaining 0.1% TFA) to yield 139.8 mg (quant.) of title compoundendo-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,6b as a TFA salt. MS m/z (MH⁺) 452.0.

Endo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,7b

Using an adaptation of Procedure 9, and substituting phenylacetaldehydefor 2-pyridyl carboxaldehyde, the title compoundendo-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,7b was obtained as a TFA salt. MS m/z (MH⁺) 464.9.

Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carbonitrile,8b

Using an adaptation of Procedure 9, and substitutingendo-3-(3-cyano-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3b forendo-3-[3-(1H-tetrazol-5-yl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]-octane-8-carboxylicacid tert-butyl ester, 4b, the title compoundendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carbonitrile,8b was obtained as a TFA salt. MS m/z (MH⁺) 317.9.

Example C

Procedure 10Endo-3-[3-(N,N-Diethyl-carbamimidoyl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]-octane-8-carboxylicacid tert-butyl ester, 1c

To a solution of methylmagnesium bromide in diethyl ether (3.0 M, 2.4mL, 7.2 mmol) under nitrogen was added dropwise a solution ofdiethylamine (0.749 mL, 7.19 mmol) in diethyl ether (2 mL). The mixturewas heated to reflux for 30 min, cooled to rt, and a suspension ofendo-3-(3-cyano-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3b (1.0 g, 2.4 mmol) was added. The mixture wasstirred at 40° C. for 2 hr and water (10 mL) was added. The organiclayer was separated, and the aqueous layer was further extracted withchloroform (2×10 mL). The combined organic layers were dried overmagnesium sulfate, filtered, and evaporated, yielding title compoundendo-3-[3-(N,N-diethyl-carbamimidoyl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]-octane-8-carboxylicacid tert-butyl ester 1c. MS m/z (MH⁺) 491.0.The residue was used assuch for the next reaction.

Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-N,N-diethyl-10H-phenoxazine-3-carboxamidine,2c

Using an adaptation of Procedure 8, and substitutingendo-343-(N,N-Diethyl-carbamimidoyl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]-octane-8-carboxylicacid tert-butyl ester, 4b forendo-3-[3-(1H-tetrazol-5-yl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]-octane-8-carboxylicacid tert-butyl ester, 4b, the title compoundendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-N,N-diethyl-10H-phenoxazine-3-carboxamidine,2c was obtained as a TFA salt. MS m/z (MH⁺) 390.9.

Endo-N,N-Diethyl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxamidine,3c

Using an adaptation of Procedure 8, and substitutingendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-N,N-diethyl-10H-phenoxazine-3-carboxamidine,2c forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, the title compoundendo-N,N-diethyl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxamidine,3c was obtained as a TFA salt. MS m/z (MH⁺) 482.0.

Endo-N,N-Diethyl-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxamidine,4c

Using an adaptation of Procedure 9, substitutingendo-N,N-diethyl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxamidine,3c forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b and phenyl acetaldehyde for 2-pyridyl carboxaldehyde, the titlecompoundendo-N,N-diethyl-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxamidine,4c was obtained as a TFA salt. MS m/z (MH⁺) 495.0.

Example D

Procedure 11Endo-3-[3-(N-Hydroxycarbamimidoyl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1d andendo-3-(3-Carbamoyl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2d

To a solution ofendo-3-(3-cyano-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3b (1 g; 2.40 mmol) in ethanol (20 mL) were addedammonium hydroxide hydrochloride (0.5 g; 7.19 mmol) and potassiumcarbonate (0.66 g; 4.78 mmol), and the mixture was heated to reflux for16 h. The mixture was allowed to cool to rt, water (20 mL) was added,and the mixture was extracted with ethyl acetate (2×20 mL). The combinedorganic layers were dried over MgSO₄, filtered, and evaporated, yieldinga ˜2:1 mixture of title compoundsendo-343-(N-hydroxycarbamimidoyl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1d andendo-3-(3-carbamoyl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2d. The crude mixture was used as such in thenext reaction. 1d: MS m/z (MH⁺) 451.2, 2d: MS m/z (MH⁺) 458.3.

Procedure 12Endo-3-[3-(5-Oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3d

To a solution of the 2:1 mixture ofendo-3-[3-(N-hydroxycarbamimidoyl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1d andendo-3-(3-carbamoyl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2d (2.33 mmol) in dioxane (20 mL) was added1,1′-carbonyldiimidazole (0.57 g; 3.52 mmol), and the mixture wasstirred at 110° C. for 4 h. The mixture was allowed to cool to rt, andthe solution containing a crude mixture ofendo-3-[3-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]-octane-8-carboxylicacid tert-butyl ester, 3d (MS m/z (MH⁺) 477.1)andendo-3-(3-carbamoyl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2d was used as such in the next reaction.

Endo-3-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-4H-[1,2,4]oxadiazol-5-one,4d andendo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic acidamide, 5d

Using an adaptation of Procedure 8, and substituting a mixture ofendo-3-[3-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]-octane-8-carboxylicacid tert-butyl ester, 3d andendo-3-(3-carbamoyl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2d forendo-3-[3-(1H-tetrazol-5-yl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]-octane-8-carboxylicacid tert-butyl ester, 4b, the title compoundsendo-3-[10-(8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-4H-[1,2,4]oxadiazol-5-one,4d andendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic acidamide, 5d were obtained as TFA salts. 4d: MS m/z (MH⁺) 377.0; 5d: MS m/z(MH⁺) 335.9.

Endo-3-[10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-4H-[1,2,4]oxadiazol-5-one,6d

Using an adaptation of Procedure 9, and substitutingendo-3-[10-(8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-4H-[1,2,4]oxadiazol-5-one,4d forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, the title compoundendo-3-[10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-4H-[1,2,4]oxadiazol-5-one,6d was obtained as a TFA salt. MS m/z (MH⁺) 467.9.

Endo-3-[10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-4H-[1,2,4]oxadiazol-5-one,7d

Using an adaptation of Procedure 9, and substitutingendo-3-[10-(8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-4H-[1,2,4]oxadiazol-5-one,4d forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, and phenyl acetaldehyde for 2-pyridyl carboxaldehyde, the titlecompoundendo-3-[10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-4H-[1,2,4]oxadiazol-5-one,7d was obtained as a TFA salt MS m/z (MH⁺) 480.9.

Example E

Procedure 13 1-Fluoro-3-methoxy-2-nitrobenzene, 1e

To a solution of 2,6-difluoronitrobenzene (5 g, 32 mmol) in methanol (50mL) was added potassium hydroxide (1.8 g, 32.5 mmol), and the mixturewas heated to reflux for 3 hr. Water was added, and the mixture wasextracted with dichloromethane. The organic layer was separated, dried,filtered, and evaporated to yield 5.1 g (95%) of1-fluoro-3-methoxy-2-nitrobenzene, 1e. MS m/z (MH⁺) 172.

6-Methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic acid methyl ester, 2e

Using an adaptation of Procedure 2, and substituting1-fluoro-3-methoxy-2-nitrobenzene, 1e for 4-fluoro-3-nitrobenzonitrile,the title compound6-methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid methyl ester, 2e was obtained as a TFA salt and as a mixture ofendo and exo isomers. MS m/z (MH⁺) 395.

Procedure 146-Methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid, 3e

To a solution of the TFA salt of6-methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid methyl ester, 2e (270 mg, 0.7 mmol) in dioxane (15 mL) was addedsodium hydroxide (31 mg, 0.77 mmol) for10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid methyl ester, 2a, the title compound6-methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid, 3e was obtained as a mixture of endo and exo isomers. MS m/z (MH⁺)381.

10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 4e

Using an adaptation of Procedure 4, and substituting6-methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid, 3e for10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid, 3a, N,N-diisopropyl-N-ethylamine for triethylamine and HATU forHBTU, the title compound10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 4e was obtained as a TFA salt and as a mixture ofendo and exo isomers. MS m/z (MH⁺) 436.

Procedure 1510-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-10H-phenoxazine-3-carboxylicacid diethylamide, 5e

To a solution of the TFA salt of10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 4e (110 mg, 0.25 mmol) in methylene chloride (10 mL)was added 1-chloroethyl chloroformate (0.58 mL, 0.75 mmol). The mixturewas heated to reflux for 2 h. The mixture was evaporated, dissolved inmethanol (5 mL), and heated for 2 h at reflux. Water was added, and thesolution was extracted with methylene chloride. The organic phase wasseparated, evaporated, and purified via reverse phase HPLC to yield 69mg (44.8%) of title compound10-(8-aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-10H-phenoxazine-3-carboxylicacid diethylamide, 5e, as a TFA salt. MS m/z=422 (M+1).

6-Methoxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 6e

Using an adaptation of Procedure 9, and substituting10-(8-aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-10H-phenoxazine-3-carboxylicacid diethylamide, 5e forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, and phenyl acetaldehyde for 2-pyridylcarboxaldehyde, the titlecompound6-methoxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 6e was obtained as a TFA salt and as a mixture ofendo and exo isomers. MS m/z=526 (M+1).

Procedure 166-Hydroxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 7e

To a solution of the TFA salt of6-methoxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 6e (55 mg, 0.086 mmol) in 1,2-dichloromethane (5 mL)at 0° C. was added a 1M solution of BBr₃ (0.43 mL, 0.43 mmol). Themixture was allowed to stir for 2 h at rt. A saturated NaHCO₃ solutionwas added, and the organic phase was separated. The aqueous phase wasextracted with methylene chloride, and the combined organic phases weredried, filtered, and evaporated. The residue was purified via reversephase HPLC (eluent: CH3CN in water containing 0.1% TFA) to yield 23 mg(42.8%) of title compound6-hydroxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 7e as a TFA salt and as a mixture of endo and exoisomers. MS m/z=512 (M+1).

6-Methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 8e

Using an adaptation of Procedure 16, and substituting the TFA salt of10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 4e for TFA salt of6-methoxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 6e, the title compound6-methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 8e was obtained as a TFA salt and as a mixture ofendo and exo isomers after reverse phase chromatography (eluentgradient: acetonitrile in water containing 0.1% TFA). MS m/z (MH⁺) 422.

Example F

2-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-phenol, 1f

Using an adaptation of Procedure 5, and substituting8-methyl-8-aza-bicyclo[3.2.1]-octan-3-one for3-oxo-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester, thetitle compound 2-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-phenol, 1fwas obtained as a TFA salt and as a mixture of endo and exo isomersafter reverse phase chromatography (eluent gradient: acetonitrile inwater containing 0.1% TFA). MS m/z (MH⁺) 232.9.

10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carbonitrile,2f

Using an adaptation of Procedure 6, and substituting the TFA salt of2-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-phenol, 1f for3-(2-hydroxy-phenylamino)-8-aza-bicyclo[3.2.1]octane-8-carboxylic acidtert-butyl ester, 1b, the title compound10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carbonitrile,2f was obtained as a mixture of endo and exo isomers. MS m/z (MH⁺)332.0.

10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,3f

Using an adaptation of Procedure 7, and substituting10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carbonitrile,2f for3-(3-cyano-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2b, the title compound10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,3f was obtained as a TFA salt and as a mixture of endo and exo isomersafter reverse phase chromatography (eluent gradient: acetonitrile inwater containing 0.1% TFA). MS m/z (MH⁺) 375.1.

Example G

N,N-Diethyl-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxamidine,1g

Using an adaptation of Procedure 10, and substituting10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carbonitrile,2f forendo-3-(3-cyano-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3b, the title compoundN,N-diethyl-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxamidine,1g was obtained as a TFA salt and as a mixture of endo and exo isomersafter reverse phase chromatography (eluent gradient: acetonitrile inwater containing 0.1% TFA). MS m/z (MH⁺) 405.3.

Example H

N-Hydroxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxamidine,1h

Using an adaptation of Procedure 11, and substituting10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carbonitrile,2f forendo-3-(3-cyano-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3b, the title compoundN-Hydroxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxamidine,1h was obtained. MS m/z (MH⁺) 365.0.

Procedure 173-[10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-4H-[1,2,4]oxadiazol-5-one,2h

To a solution ofN-Hydroxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxamidine,1h (0.66 g; 1.81 mmol) in dioxane (20 mL) was added1,1′-carbonyldiimidazole (0.44 g; 2.71 mmol), and the mixture wasstirred at 110° C. for 4 h. The mixture was allowed to cool to rt, andthe solvent was evaporated. The residue was purified via reverse phaseHPLC (eluent gradient: 20 to 45% CH₃CN in H₂O containing 0.1% TFA) toyield 161 mg (17.6%) of title compound3-[10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-4H-[1,2,4]oxadiazol-5-one,2 h as a TFA salt. MS m/z (MH⁺) 390.9.

Example I

Procedure 18 Spiro Compound, 1i

A mixture of 2-aminothiophenol (4.3 mL, 39.9 mmol) and tropinone (5.6 g,39.9 mmol) was allowed to stir and sit for 16 h at rt. The mixture wasplaced under vacuum (<0.3 mm Hg) for 6 h. HPLC-MS analysis revealed ˜60%conversion to desired compound, 1i. The material was used as such forthe next reaction.

Procedure 19[2-(4-Bromo-2-nitrophenylsulfanyl)-phenyl]-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amine,2i

To the mixture obtained from the previous reaction (Procedure 18) wasadded THF (20 mL), and the mixture was cooled to −78° C. A 1M solutionof lithium aluminum hydride in diethyl ether (60 mL, 60 mmol) was addedin portions. The cooling bath was removed. More THF (60 mL) and 10 mL ofthe 1M solution of lithium aluminum hydride were added. The mixture wasstirred at rt for 90 min, cooled to −78° C., and treated with water (2.6mL). The cooling bath was removed, and the mixture was allowed to warmto rt. A 1N NaOH solution (10.6 mL) was added, and the mixture wasallowed to stir for 15 min. MgSO₄ (1 g) and THF (40 mL) were added, andthe mixite was filtered. To the filtrate was added2-fluoro-5-bromo-nitrobenzene (5.4 mL, 43.8 mmol), and the mixture wasstirred for 15 min. The reaction mixture was filtered, and the solid waswashed with THF (3×20 mL) and ethyl acetate (4×20 mL). The combinedfiltrates were evaporated, and the residue was purified via flash columnchromatography (eluent gradient: 20% EtOAc containing 1% Et₃N in heptaneto 20% MeOH containing 1% Et₃N in EtOAc), yielding 10 g (55.9%) of titlecompound[2-(4-bromo-2-nitrophenylsulfanyl)-phenyl]-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amine,2i as a mixture of endo and exo isomers.

Procedure 203-Bromo-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine, 3i

To a solution of[2-(4-bromo-2-nitrophenylsulfanyl)-phenyl]-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amine,2i (9.7 g, 21.6 mmol) in DMSO (220 mL) was added potassium carbonate(3.3 g, 23.8 mmol). The mixture was heated under a N₂ atmosphere to 170°C. for 45 min. The mixture was allowed to cool to rt, diluted with H₂O(250 mL), and extracted with EtOAc (4×100 mL). The organic phase wasdried over Na₂SO₄, filtered, and evaporated. The residue was purifiedvia flash column chromatography (eluent gradient: 1% Et₃N in EtOAc to30% MeOH in EtOAc containing 1% Et₃N), yielding 1.9 g (21.9%) of titlecompound3-bromo-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine, 3ias a mixture of endo and exo isomers. MS m/z (MH⁺) 401.1/403.1.

Procedure 2110-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-bromo-10H-phenothiazine, 4i

To a solution of3-bromo-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine, 3i(1.0 g, 2.49 mmol) in 1,2-dichloroethane (15 mL) were added1-chloroethyl chloroformate (807 μL, 7.5 mmol) andN,N-diisopropyl-N-ethylamine (1.4 mL, 7.97 mmol). The mixture was heatedto reflux for 2.5 h, allowed to cool to rt, and evaporated. The mixturewas evaporated and the residue was dissolved dissolved in methanol (15mL) and heated to reflux for 1 h. After work-up, the residue waspurified via flash column chromatography (eluent gradient: 0 to 30% MeOHin EtOAc containing 1% triethylamine) to yield 150 mg of recoveredstarting material 3i and 382 mg (66%) of title compound3-bromo-10-piperidin-4-yl-10H-phenothiazine, 4i as a mixture of endo andexo isomers. MS m/z (MH⁺) 387.1/389.1.

Procedure 223-Bromo-10-(8-furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine,5i

To a solution of 3-bromo-10-piperidin-4-yl-10H-phenothiazine, 4i (11.2mg; 0.029 mmol) and 3-furyl carboxaldehyde (8.4 mg; 0.087 mmol) indichloroethane (120 μL) was added acetic acid (5 μL) and a solution ofsodium triacetoxyborohydride (12 mg, 0.057 mmol) in DMF (100μ). Themixture was stirred at rt for 18 h, quenched with water (50 μL), andlyophilized. The thus obtained crude3-bromo-10-(8-furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine,5i as a mixture of endo and exo isomers was used as such for the nextreaction.

Procedure 2310-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenothiazine,6i

A mixture of3-bromo-10-(8-furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine,5i (13.5 mg, 0.029 mmol), 3-pyridyl boronic acid (10.7 mg, 0.087 mmol),potassium carbonate (12 mg, 0.087 mmol) and Pd(PPh₃)₄ (3 mg, 2.5 μmol)in NMP (300 μL) and H₂O (100 μL) was heated to 160° C. for 10 min in amicrowave. The mixture was absorbed onto a 1 g SPE cartridge and eluted(eluent: 10% methanol in ethyl acetate containing 1% triethylamine). Theeluent (˜15 mL) was collected and evaporated. The residue was purifiedvia reverse phase HPLC (eluent: acetonitrile in water containing 0.1%TFA) to yield title compound10-(8-furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenothiazine,6i as a TFA salt and as a mixture of endo and exo isomers. MS m/z (MH⁺)466.2.

N-{2-[10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-phenyl}-acetamide,7i

Using an adaptation of the method described in Procedure 23,substituting 2-acetylaminophenyl boronic acid for 3-pyridyl boronicacid, the title compoundN-{2-[10-(8-furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-phenyl}-acetamide,7i was obtained as a TFA salt and as a mixture of endo and exo isomers.MS m/z (MH⁺) 522.2.

10-[8-(3-Methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-3-pyridin-3-yl-10H-phenothiazine,8i

Using an adaptation of the methods described in Procedures 22 and 23,substituting 3-methyl-but-2-enal for 3-furyl carboxaldehyde in Procedure22, the title compound10-[8-(3-methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-3-pyridin-3-yl-10H-phenothiazine,8i was obtained as a TFA salt and as a mixture of endo and exo isomers.MS m/z (MH⁺) 454.3.

3-Pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine,9i

Using an adaptation of the methods described in Procedures 22 and 23,substituting 2-pyridyl carboxaldehyde for 3-furyl carboxaldehyde inProcedure 22, the title compound3-pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine,9i was obtained as a TFA salt and as a mixture of endo and exo isomers.MS m/z (MH⁺) 477.2.

10-[8-(3-Methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-3-pyridin-4-yl-10H-phenothiazine,10i

Using an adaptation of the methods described in Procedures 22 and 23,substituting 3-methyl-but-2-enal for 3-furyl carboxaldehyde in Procedure22, and 4-pyridyl boronic acid for 3-pyridyl boronic acid in Procedure23, the title compound10-[8-(3-methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-3-pyridin-4-yl-10H-phenothiazine,10i was obtained as a TFA salt and as a mixture of endo and exo isomers.MS m/z (MH⁺) 454.3.

3-Pyridin-4-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine,11i

Using an adaptation of the methods described in Procedures 22 and 23,substituting 2-pyridyl carboxaldehyde for 3-furyl carboxaldehyde inProcedure 22, and 4-pyridyl boronic acid for 3-pyridyl boronic acid inProcedure 23, the title compound3-pyridin-4-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine,11i was obtained as a TFA salt and as a mixture of endo and exo isomers.MS m/z (MH⁺) 477.3.

3-Pyridin-4-yl-10-(8-thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine,12i

Using an adaptation of the methods described in Procedures 22 and 23,substituting 2-thiophene carboxaldehyde for 3-furyl carboxaldehyde inProcedure 22, and 4-pyridyl boronic acid for 3-pyridyl boronic acid inProcedure 23, the title compound3-pyridin-4-yl-10-(8-thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine,12i was obtained as a TFA salt and as a mixture of endo and exo isomers.MS m/z (MH⁺) 482.2.

N-{2-[10-(8-Allyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-phenyl}-acetamide,13i

Using an adaptation of the methods described in Procedures 22 and 23,substituting propenal for 3-furyl carboxaldehyde in Procedure 22, and2-acetylaminophenyl boronic acid for 3-pyridyl boronic acid in Procedure23, the title compoundN-{2-[10-(8-allyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-phenyl}-acetamide,13i was obtained as a TFA salt and as a mixture of endo and exo isomers.

N-{2-[10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-phenyl}-acetamide,14i

Using an adaptation of the methods described in Procedures 22 and 23,substituting phenyl acetaldehyde for 3-furyl carboxaldehyde in Procedure22, and 2-acetylaminophenyl boronic acid for 3-pyridyl boronic acid inProcedure 23, the title compoundN-{2-[10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-phenyl}-acetamide,14i was obtained as a TFA salt and as a mixture of endo and exo isomers.MS m/z (MH⁺) 546.3.

N-(2-{10-[8-(1H-Imidazol-2-ylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenothiazin-3-yl}-phenyl)-acetamide,15i

Using an adaptation of the methods described in Procedures 22 and 23,substituting 1H-imidazole-2-carboxaldehyde for 3-furyl carboxaldehyde inProcedure 22, and 2-acetylaminophenyl boronic acid for 3-pyridyl boronicacid in Procedure 23, the title compoundN-(2-{10-[8-(1H-Imidazol-2-ylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenothiazin-3-yl}-phenyl)-acetamide,15i was obtained as a TFA salt and as a mixture of endo and exo isomers.MS m/z (MH⁺) 522.3.

N-{2-[10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-phenyl}-acetamide,16i

Using an adaptation of the method described in Procedure 23,substituting3-bromo-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine, 3ifor3-bromo-10-(8-furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine,5i and 2-acetylaminophenyl boronic acid for 3-pyridyl boronic acid, thetitle compoundN-{2-[10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-phenyl}-acetamide,16i was obtained as a TFA salt and as a mixture of endo and exo isomers.MS m/z (MH⁺) 456.2.

10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenothiazine, 17i

Using an adaptation of the method described in Procedure 23,substituting 3-bromo-10-piperidin-4-yl-10H-phenothiazine, 4i for3-bromo-10-(8-furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine,5i, the title compound10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenothiazine, 17iwas obtained as a TFA salt and as a mixture of endo and exo isomers. MSm/z (MH⁺) 386.2.

N-{2-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-phenyl}-acetamide,18i

Using an adaptation of the method described in Procedure 23,substituting10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-bromo-10H-phenothiazine, 4i for3-bromo-10-(8-furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine,5i and 2-acetylaminophenyl boronic acid for 3-pyridyl boronic acid, thetitle compoundN-{2-[10-(8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-phenyl}-acetamide,18i was obtained as a TFA salt and as a mixture of endo and exo isomers.MS m/z (MH⁺) 442.2.

10-(8-Allyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenothiazine,19i

Using an adaptation of the methods described in Procedures 22 and 23,substituting 2-propenal for 3-furyl carboxaldehyde in Procedure 22, thetitle compound10-(8-allyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenothiazine,19i was obtained as a TFA salt and as a mixture of endo and exo isomers.MS m/z (M+18+H) 444.2.

Endo-3-(4-Chloro-2-hydroxyphenylamino)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1j andexo-3-(4-chloro-2-hydroxyphenyl-amino)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2j

Using an adaptation of the method described in Procedure 1, substituting2-amino-5-chlorophenol for 4-amino-3-hydroxybenzoic acid methyl esterand 3-oxo-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl esterfor 8-methyl-8-aza-bicyclo[3.2.1]octan-3-one, a 3:1 mixture of titlecompoundsendo-3-(4-chloro-2-hydroxyphenylamino)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1j andexo-3-(4-chloro-2-hydroxyphenyl-amino)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2j was obtained. Compounds 1j and 2j wereseparated via flash column chromatography (eluent gradient: 3% to 65%EtOAc in hexane), yielding 70% of endo isomer 1j (first eluting isomer;and 19% of exo isomer 2j (second eluting isomer)

Endo-3-(3-Chlorophenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3j

Using an adaptation of the method described in Procedure 2, substitutingendo-3-(4-chloro-2-hydroxyphenylamino)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1j for the TFA salt of3-hydroxy-4-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-benzoic acidmethyl ester, 1a, the title compoundendo-3-(3-chlorophenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3j was obtained.

Procedure 24Endo-3-(3-Pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 4j

To a mixture of 3-pyridyl boronic acid (70.1 mg, 0.57 mmol),Cp₂Fe(P-tBu₂)₂PdCl₂ (62 mg, 0.095 mmol), potassium carbonate (88 mg,0.63 mmol) was added a solution ofendo-3-(3-chlorophenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3j (135 mg, 0.317 mmol) in dioxane (3 mL,degassed with argon for 5 min prior to use). The mixture was heated to120° C. for 30 min in a microwave (300 W). The mixture was allowed tocool to rt, water and ethyl acetate were added. The organic layer wasseparated, dried over MgSO4, filtered, and evaporated to yield 195 mg ofcrude title compoundendo-3-(3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 4j. The material was used as such for the nextreaction.

Procedure 25Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine,5j

The crudeendo-3-(3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 4j, obtained from the previous reaction, wastreated with TFA (3 mL), and the mixture was stirred for 30 min at rt.The TFA was removed under a nitrogen stream, and the residue waspurified via reverse phase HPLC (eluent gradient: 10% to 30% CH₃CN inwater containing 0.1% TFA). The desired fractions were combined,lyophilized, and dissolved in diethyl ether. The solution was washedwith a saturated NaHCO₃ solution. The aqueous phase was washed withdiethyl ether, and the combined organic phases were dried over MgSO₄,filtered, and evaporated to yield 58 mg (43% for 2 steps) of titlecompoundendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine,5j. MS m/z (MH⁺) 370.2.

Endo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine,6j

Using an adaptation of the method described in Procedure 9, substitutingendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine,5j for the HCl salt of10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,4b and phenyl acetaldehyde for 2-pyridylcarboxaldehyde, the titlecompoundendo-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine,6j was obtained as a TFA salt. MS m/z (MH⁺) 474.2.

Endo-3-Pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine,7j

Using an adaptation of the method described in Procedure 9, substitutingendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine,5j for the HCl salt of10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,4b and 2-pyridyl carboxaldehyde for 2-pyridylcarboxaldehyde, the titlecompoundendo-3-pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine,7j was obtained as a TFA salt. MS m/z (MH⁺) 461.2.

Endo-10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine,8j

Using an adaptation of the method described in Procedure 9, substitutingendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine,5j for the HCl salt of10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,4b and 3-furaldehyde for 2-pyridylcarboxaldehyde, the title compoundendo-10-(8-furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine,8j was obtained as a TFA salt. MS m/z (MH⁺) 450.2.

Endo-3-Pyridin-3-yl-10-(8-thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine,9j

Using an adaptation of the method described in Procedure 9, substitutingendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine,5j for the HCl salt of10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,4b and 2-thiophene carboxaldehyde for 2-pyridylcarboxaldehyde, the titlecompoundendo-3-pyridin-3-yl-10-(8-thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine,9j was obtained as a TFA salt. MS m/z (MH⁺) 466.2.

Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-chloro-10H-phenoxazine, 10j

Using an adaptation of the method described in Procedure 25,substituting endo-3-(3-chloro-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester, 3j forendo-3-(3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 4j, the title compoundendo-10-(8-aza-bicyclo[3.2.1]-oct-3-yl)-3-chloro-10H-phenoxazine, 10jwas obtained as a TFA salt after reverse phase HPLC purification(eluent: CH₃CN in water containing 0.1% TFA). MS m/z (MH⁺) 327.1.

Example K

Endo-3-(3-Pyridin-4-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1k

Using an adaptation of the method described in Procedure 24,substituting 4-pyridyl boronic acid for 3-pyridyl boronic acid, thetitle compoundendo-3-(3-pyridin-4-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1k was obtained.

Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine,2k

Using an adaptation of the method described in Procedure 25,substitutingendo-3-(3-pyridin-4-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1k forendo-3-(3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]-octane-8-carboxylicacid tert-butyl ester, 4j, the title compoundendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine,2k was obtained as a TFA salt after reverse phase HPLC purification(eluent gradient: 10% to 30% CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 370.2.

Endo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine,3k

Using an adaptation of the method described in Procedure 9, substitutingthe TFA salt ofendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine,2k for the HCl salt of10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,4b and phenyl acetaldehyde for 2-pyridyl carboxaldehyde, the titlecompoundendo-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine,3k was obtained as a TFA salt. MS m/z (MH⁺) 474.3.

Endo-3-Pyridin-4-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine,4k

Using an adaptation of the method described in Procedure 9, substitutingthe TFA salt ofendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine,2k for the HCl salt of10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,4b, the title compoundendo-3-pyridin-4-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine,4k was obtained as a TFA salt. MS m/z (MH⁺) 461.3.

Endo-10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine,5k

Using an adaptation of the method described in Procedure 9, substitutingthe TFA salt ofendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine,2k for the HCl salt of10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,4b and 3-furaldehyde for 2-pyridylcarboxaldehyde, the title compoundendo-10-(8-furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine,5k was obtained as a TFA salt. MS m/z (MH⁺) 450.3.

Endo-3-Pyridin-4-yl-10-(8-thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine,6k

Using an adaptation of the method described in Procedure 9, substitutingthe TFA salt ofendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine,2k for the HCl salt of10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,4b and 2-thiophene carboxaldehyde for 2-pyridylcarboxaldehyde, the titlecompoundendo-3-pyridin-4-yl-10-(8-thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine,6k was obtained as a TFA salt. MS m/z (MH⁺) 466.2.

Example L

Exo-3-(3-Chlorophenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1l

Using an adaptation of the method described in Procedure 2, substitutingexo-3-(4-chloro-2-hydroxyphenylamino)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2j for the TFA salt of3-hydroxy-4-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-benzoic acidmethyl ester, 1a, the title compoundexo-3-(3-chlorophenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1l was obtained.

Endo-3-(3-Pyridin-4-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2l

Using an adaptation of the method described in Procedure 24,substitutingexo-3-(3-chlorophenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1l forendo-3-(3-chlorophenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3j, the title compound3-(3-pyridin-4-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2l was obtained.

Exo-3-(3-Pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3l

Using an adaptation of the method described in Procedure 25,substitutingexo-3-(3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2l forendo-3-(3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]-octane-8-carboxylicacid tert-butyl ester, 4j, the title compoundexo-3-(3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3l was obtained as a TFA salt after reverse phaseHPLC purification (eluent gradient: 10% to 30% CH₃CN in water containing0.1% TFA). MS m/z (MH⁺) 370.2.

Exo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine,4l

Using an adaptation of the method described in Procedure 9, substitutingthe TFA salt ofexo-3-(3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3l for the HCl salt of 10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine, 4b and phenylacetaldehyde for 2-pyridyl carboxaldehyde, the title compoundexo-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine,4l was obtained as a TFA salt. MS m/z (MH⁺) 474.3.

Exo-3-Pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine,5l

Using an adaptation of the method described in Procedure 9, substitutingthe TFA salt ofexo-3-(3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3l for the HCl salt of10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,4b, the title compoundexo-3-pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine,5l was obtained as a TFA salt. MS m/z (MH⁺) 461.3.

Exo-10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine,6l

Using an adaptation of the method described in Procedure 9, substitutingthe TFA salt ofexo-3-(3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3l for the HCl salt of 10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine, 4b and 3-furaldehydefor 2-pyridyl carboxaldehyde, the title compoundexo-10-(8-furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine,6l was obtained as a TFA salt. MS m/z (MH⁺) 450.2.

Exo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-chloro-10H-phenoxazine, 7l

Using an adaptation of the method described in Procedure 25,substitutingexo-3-(3-chloro-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1l forendo-3-(3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 4j, the title compoundexo-10-(8-aza-bicyclo[3.2.1]-oct-3-yl)-3-chloro-10H-phenoxazine, 7l wasobtained as a TFA salt after reverse phase HPLC purification (eluent:CH₃CN in water containing 0.1% TFA). MS m/z (MH⁺) 327.1.

Example M

Exo-3-(3-Pyridin-4-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1m

Using an adaptation of the method described in Procedure 24,substituting 4-pyridyl boronic acid for 3-pyridyl boronic acid, thetitle compoundexo-3-(3-pyridin-4-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1m was obtained.

Exo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine, 2m

Using an adaptation of the method described in Procedure 25,substitutingexo-3-(3-pyridin-4-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1l forendo-3-(3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]-octane-8-carboxylicacid tert-butyl ester, 4j, the title compoundexo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine, 2mwas obtained as a TFA salt after reverse phase HPLC purification (eluentgradient: 10% to 30% CH₃CN in water containing 0.1% TFA). MS m/z (MH⁺)370.2.

Exo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine,3m

Using an adaptation of the method described in Procedure 9, substitutingthe TFA salt ofexo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine, 2mfor the HCl salt of10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,4b and phenyl acetaldehyde for 2-pyridyl carboxaldehyde, the titlecompoundexo-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine,3m was obtained as a TFA salt. MS m/z (MH⁺) 474.3.

Exo-3-Pyridin-4-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine,4m

Using an adaptation of the method described in Procedure 9, substitutingthe TFA salt ofexo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine, 2mfor the HCl salt of10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,4b, the title compoundexo-3-pyridin-4-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine,4m was obtained as a TFA salt. MS m/z (MH⁺) 461.2.

Exo-10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine,5m

Using an adaptation of the method described in Procedure 9, substitutingthe TFA salt ofexo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine, 2mfor the HCl salt of10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,4b and 3-furaldehyde for 2-pyridyl carboxaldehyde, the title compoundexo-10-(8-furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine,5m was obtained as a TFA salt. MS m/z (MH⁺) 450.2.

Example N

Exo-3-(3-Cyano-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1n

Using an adaptation of the method described in Procedure 6, substitutingexo-3-(2-hydroxy-phenylamino)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2b forendo-3-(2-hydroxy-phenylamino)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1b, the title compoundexo-3-(3-cyano-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1n was obtained. MS m/z (MH⁺) 439.9.

Exo-343-(1H-Tetrazol-5-yl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2n

Using an adaptation of the method described in Procedure 7, substitutingexo-3-(3-cyano-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1n forendo-3-(3-cyano-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3b, the title compoundexo-3-[3-(1H-tetrazol-5-yl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2n was obtained. MS m/z (MH⁺) 460.9.

Exo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,3n

Using an adaptation of the method described in Procedure 8, substitutingexo-3-[3-(1H-tetrazol-5-yl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]-octane-8-carboxylicacid tert-butyl ester, 2n forendo-3-[3-(1H-tetrazol-5-yl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]-octane-8-carboxylicacid tert-butyl ester, 4b, the title compoundexo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,3n was obtained as a TFA salt after purification via reverse phase HPLC(eluent: CH₃CN in water containing 0.1% TFA). MS m/z (MH⁺) 360.9.

Exo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carbonitrile, 4n

Using an adaptation of the method described in Procedure 25,substitutingexo-3-(3-cyano-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1n forendo-3-(3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 4j, and using a 1:1 solution of TFA;CH₂Cl₂instead of neat TFA, the title compoundexo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carbonitrile, 4nwas obtained as a TFA salt after reverse phase HPLC purification (eluentgradient: 20% to 45% CH₃CN in water containing 0.1% TFA). MS m/z (MH⁺)317.9.

Example O

Exo-3-[3-(N-Hydroxycarbamimidoyl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1o

Using an adaptation of the method described in Procedure 11,substitutingexo-3-(3-cyano-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1n forendo-3-(3-cyano-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3b, the title compoundexo-3-[3-(N-hydroxycarbamimidoyl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1o was obtained. MS m/z (MH⁺) 450.9.

Exo-3-[3-(5-Oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2o

Using an adaptation of the method described in Procedure 12,substitutingexo-3-[3-(N-hydroxycarbamimidoyl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1o for the mixture ofendo-3-[3-(N-hydroxycarbamimidoyl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1d andendo-3-(3-carbamoyl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2d, the title compoundexo-3-[3-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2o was obtained.

Exo-3-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-4H-[1,2,4]oxadiazol-5-one,3o

Using an adaptation of Procedure 8, and substitutingexo-3-[3-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2o forendo-3-[3-(1H-tetrazol-5-yl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]-octane-8-carboxylicacid tert-butyl ester, 4b, the title compoundexo-3-[10-(8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-4H-[1,2,4]oxadiazol-5-one,3o was obtained as TFA salt after purification via reverse phase HPLC(eluent gradient: 20% to 45% CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 376.8.

Example P

3-Methoxy-4-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-benzonitrile,1p

Using an adaptation of Procedure 2, substituting8-methyl-8-aza-bicyclo[3.2.1]oct-3-ylamine for the TFA salt of3-hydroxy-4-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-benzoic acidmethyl ester, 1a, 1-fluoro-3-methoxy-2-nitrobenzene, 1e for2-fluoronitrobenzene, and cesium carbonate for potassium carbonate, thetitle compound3-methoxy-4-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-benzonitrile,1p was obtained as TFA salt and as a mixture of endo and exo isomersafter purification via reverse phase HPLC (eluent gradient: 20% to 45%CH₃CN in water containing 0.1% TFA). MS m/z=272 (M+1).

3-Hydroxy-4-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-benzonitrile,2p

Using an adaptation of Procedure 13, substituting the TFA salt of3-methoxy-4-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-benzonitrile,1p for the TFA salt of6-methoxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 6e, the title compound3-hydroxy-4-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-benzonitrile,2p was obtained as TFA salt and as a mixture of endo and exo isomersafter purification via reverse phase HPLC (eluent gradient: 20% to 45%CH₃CN in water containing 0.1% TFA). MS m/z=258 (M+1).

6-Methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carbonitrile,3p

Using an adaptation of Procedure 2, substituting the TFA salt of3-hydroxy-4-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-benzonitrile,2p for the TFA salt of3-hydroxy-4-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-benzoic acidmethyl ester, 1a, and 1-fluoro-3-methoxy-2-nitrobenzene, 1e for2-fluoronitrobenzene, the title compound6-methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carbonitrile,3p was obtained as TFA salt and as a mixture of endo and exo isomersafter purification via reverse phase HPLC (eluent gradient: 20% to 45%CH₃CN in water containing 0.1% TFA). MS m/z=362 (M+1).

6-Hydroxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carbonitrile,4p

Using an adaptation of Procedure 13, substituting the TFA salt of6-methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carbonitrile,3p for the TFA salt of6-methoxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 6e, the title compound6-hydroxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carbonitrile,4p was obtained as TFA salt and as a mixture of endo and exo isomersafter purification via reverse phase HPLC (eluent gradient: 20% to 45%CH₃CN in water containing 0.1% TFA). MS m/z=348 (M+1).

Example Q

Procedure 26[10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-pyrrolidin-1-yl-methanone,1q

To a solution of a mixture of endo and exo isomers of3-bromo-10-piperidin-4-yl-10H-phenothiazine, 4i (15 mg, 0.04 mmol) indichloroethane (0.4 mL) were added 3-furaldehyde (10 μL, 0.12 mmol),acetic acid (5 μL) and sodium triacetoxy-borohydride (17 mg, 0.08 mmol).The mixture was allowed to stir at rt for 16 h, and quenched with a 2NNaOH solution (200 μL). The mixture was absorbed onto a 1 g SPEcartridge and eluted (eluent: 10% methanol in ethyl acetate containing1% triethylamine). The eluent (˜15 mL) was collected and evaporated. Theresidue was dissolved in THF (0.4 mL), and pyrrolidine (19 μL, 0.15mmol), Mo(CO)₆ (16 mg, 0.06 mmol), Herrmann's catalyst (6 mg, 0.006mmol), and DBU (27 μL, 0.18 mmol) were added. The mixture was irradiatedin a microwave oven at 150° C. for 15 min. The mixture was evaporated,and the residue was purified via reverse phase HPLC (eluent gradient:CH₃CN in water containing 0.1% TFA) to yield[10-(8-furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-pyrrolidin-1-yl-methanone,1q as a TFA salt and as a mixture of endo and exo isomers. MS m/z (MH⁺)486.2.

[10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-pyrrolidin-1-yl-methanone,2q

Using an adaptation of Procedure 26, substituting phenyl acetaldehydefor 3-furaldehyde, the title compound[10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-pyrrolidin-1-yl-methanone,2q was obtained as TFA salt and as a mixture of endo and exo isomersafter purification via reverse phase HPLC (eluent gradient: 20% to 45%CH₃CN in water containing 0.1% TFA). MS m/z=510.3 (M+1).

{10-[8-(3-Methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenothiazin-3-yl}-pyrrolidin-1-yl-methanone,3q

Using an adaptation of Procedure 26, substituting 3-methyl-but-2-enalfor 3-furaldehyde, the title compound{10-[8-(3-methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenothiazin-3-yl}-pyrrolidin-1-yl-methanone,3q was obtained as TFA salt and as a mixture of endo and exo isomersafter purification via reverse phase HPLC (eluent gradient: 20% to 45%CH₃CN in water containing 0.1% TFA). MS m/z=474.2 (M+1).

[10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-(3-hydroxy-pyrrolidin-1-yl)-methanone,4q

Using an adaptation of Procedure 26, substituting 3-hydroxypyrrolidinefor pyrrolidine, the title compound[10-(8-furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-(3-hydroxy-pyrrolidin-1-yl)-methanone,4q was obtained as TFA salt and as a mixture of endo and exo isomersafter purification via reverse phase HPLC (eluent gradient: 20% to 45%CH₃CN in water containing 0.1% TFA). MS m/z=502.2 (M+1).

(3-Hydroxy-pyrrolidin-1-yl)-[10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-methanone,5q

Using an adaptation of Procedure 26, substituting phenyl acetaldehydefor 3-furaldehyde and 3-hydroxypyrrolidine for pyrrolidine, the titlecompound(3-hydroxy-pyrrolidin-1-yl)-[10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-methanone,5q was obtained as TFA salt and as a mixture of endo and exo isomersafter purification via reverse phase HPLC (eluent gradient: 20% to 45%CH₃CN in water containing 0.1% TFA). MS m/z=526.2 (M+1).

{10-[8-(3-Methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenothiazin-3-yl}-(3-methyl-pyrrolidin-1-yl)-methanone,6q

Using an adaptation of Procedure 26, substituting 3-methyl-but-2-enalfor 3-furaldehyde and 3-hydroxypyrrolidine for pyrrolidine, the titlecompound{10-[8-(3-methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenothiazin-3-yl}-(3-methyl-pyrrolidin-1-yl)-methanone,6q was obtained as TFA salt and as a mixture of endo and exo isomersafter purification via reverse phase HPLC (eluent gradient: 20% to 45%CH₃CN in water containing 0.1% TFA). MS m/z=490.2 (M+1).

Example R

Procedure 27[10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-pyrrolidin-1-yl-methanone,1r

To a solution of3-bromo-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine, 3i(15 mg, 0.04 mmol) in THF (0.3 mL) was added pyrrolidine (12 μL, 0.15mmol), Mo(CO)₆ (16 mg, 0.06 mmol), Herrmann's catalyst (6 mg, 0.006mmol), and DBU (27 μL, 0.18 mmol), and the mixture was irradiated in amicrowave oven at 150° C. for 15 min. The mixture was evaporated, andthe residue was purified via reverse phase HPLC (eluent gradient: CH₃CNin water containing 0.1% TFA) to yield[10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-pyrrolidin-1-yl-methanone,1r as a TFA salt and a mixture of endo and exo isomers. MS m/z (MH⁺)420.2.

(3-Hydroxy-pyrrolidin-1-yl)-[10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-methanone,2r

Using an adaptation of Procedure 27, substituting 3-hydroxypyrrolidinefor pyrrolidine, the title compound(3-hydroxy-pyrrolidin-1-yl)-[10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazin-3-yl]-methanone,2r was obtained as TFA salt and as a mixture of endo and exo isomersafter purification via reverse phase HPLC (eluent gradient: 20% to 45%CH₃CN in water containing 0.1% TFA). MS m/z=436.2 (M+1).

10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carboxylicacid ethylamide, 3r

Using an adaptation of Procedure 27, substituting ethylamine forpyrrolidine, the title compound10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carboxylicacid ethylamide, 3r was obtained as TFA salt and as a mixture of endoand exo isomers after purification via reverse phase HPLC (eluentgradient: 20% to 45% CH₃CN in water containing 0.1% TFA). MS m/z=394.2(M+1).

Example T

Endo-3-(3-Diethylcarbamoyl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1t

Using an adaptation of Procedure 6, and substitutingendo-3-(2-hydroxy-phenylamino)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1b for3-(2-hydroxy-phenylamino)-8-aza-bicyclo[3.2.1]octane-8-carboxylic acidtert-butyl ester, 1b, the title compoundendo-3-(3-diethylcarbamoyl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1t was obtained. The crude material was used assuch in the next reaction.

Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic aciddiethylamide, 2t

Using an adaptation of Procedure 25, substitutingendo-3-(3-diethylcarbamoyl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1t forendo-3-(3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 4j, and using a 25% solution of TFA in methylenechloride instead of neat TFA, the title compoundendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic aciddiethylamide, 2t was obtained as a TFA salt after purification viareverse phase HPLC (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 392.1.

Endo-10-[8-Thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 3t

Using an adaptation of Procedure 9, and substitutingendo-10-(8-aza-bicyclo-[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 2t forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, thiophene-2-carboxaldehyde for 2-pyridyl carboxaldehyde,tetrabutylammonium triacetoxyborohydride for sodiumtriacetoxyborohydride, and tetrahydrofuran for dichloroethane, the titlecompoundendo-10-(8-thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 3t was obtained as a TFA salt after purification viareverse phase HPLC (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 488.1.

Endo-10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 4t

Using an adaptation of Procedure 9, and substitutingendo-10-(8-aza-bicyclo-[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 2t forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, tetrabutylammonium triacetoxyborohydride for sodiumtriacetoxyborohydride, and tetrahydrofuran for dichloroethane, the titlecompoundendo-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 4t was obtained as a TFA salt after purification viareverse phase HPLC (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 483.1.

Endo-10-(8-Thiazol-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 5t

Using an adaptation of Procedure 9, and substitutingendo-10-(8-aza-bicyclo-[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 2t forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, thiazol-2-ylmethyl carboxaldehyde for 2-pyridyl carboxaldehyde,tetrabutylammonium triacetoxyborohydride for sodiumtriacetoxyborohydride, and tetrahydrofuran for dichloroethane, the titlecompoundendo-10-(8-thiazol-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 5t was obtained as a TFA salt after purification viareverse phase HPLC (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 489.1.

Endo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 6t

Using an adaptation of Procedure 9, and substitutingendo-10-(8-aza-bicyclo-[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 2t forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, phenyl acetaldehyde for 2-pyridyl carboxaldehyde, tetrabutylammoniumtriacetoxy-borohydride for sodium triacetoxyborohydride, andtetrahydrofuran for dichloro-ethane, the title compoundendo-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 6t was obtained as a TFA salt after purification viareverse phase HPLC (eluent: CH₃CN in water containing 0.1% TFA).

Endo-10-(8-Pyridin-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 7t

Using an adaptation of Procedure 9, and substitutingendo-10-(8-aza-bicyclo-[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 2t forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, 3-pyridyl carboxaldehyde for 2-pyridyl carboxaldehyde,tetrabutylammonium triacetoxy-borohydride for sodiumtriacetoxyborohydride, and tetrahydrofuran for dichloro-ethane, thetitle compoundendo-10-(8-pyridin-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 7t was obtained as a TFA salt after purification viareverse phase HPLC (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 483.1.

Endo-10-[8-(3-Methyl-but-2-enyl)-8-aza-bicycio[3.2.1]oct-3-yl]-10H-phenoxazine-3-carboxylicacid diethylamide

Using an adaptation of Procedure 9, and substitutingendo-10-(8-aza-bicyclo-[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 2t forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, 3-methyl-but-2-enyl carboxaldehyde for 2-pyridyl carboxaldehyde,tetrabutylammonium triacetoxyborohydride for sodiumtriacetoxyborohydride, and tetrahydrofuran for dichloroethane, the titlecompoundendo-10-[8-(3-methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenoxazine-3-carboxylicacid diethylamide, 8t was obtained as a TFA salt after purification viareverse phase HPLC (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 460.1.

Endo-10-[8-(1H-Imidazol-2-ylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenoxazine-3-carboxylicacid diethylamide, 9t

Using an adaptation of Procedure 9, and substitutingendo-10-(8-aza-bicyclo-[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 2t forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, 1H-imidazol-2-ylmethyl carboxaldehyde for 2-pyridyl carboxaldehyde,tetrabutylammonium triacetoxyborohydride for sodiumtriacetoxyborohydride, and tetrahydrofuran for dichloroethane, the titlecompoundendo-10-[8-(1H-imidazol-2-ylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenoxazine-3-carboxylicacid diethylamide, 9t was obtained as a TFA salt after purification viareverse phase HPLC (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 472.1.

Endo-10-(8-Benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 10t

Using an adaptation of Procedure 9, and substitutingendo-10-(8-aza-bicyclo-[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 2t forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, benzaldehyde for 2-pyridyl carboxaldehyde, tetrabutylammoniumtriacetoxyborohydride for sodium triacetoxyborohydride, andtetrahydrofuran for dichloroethane, the title compoundendo-10-(8-benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 10t was obtained as a TFA salt after purification viareverse phase HPLC (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 482.1.

Example U

Exo-3-(3-Diethylcarbamoyl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1u

Using an adaptation of Procedure 6, and substitutingexo-3-(2-hydroxy-phenylamino)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2b for3-(2-hydroxy-phenylamino)-8-aza-bicyclo[3.2.1]octane-8-carboxylic acidtert-butyl ester, 1b, the title compoundexo-3-(3-diethylcarbamoyl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1u was obtained. The crude material was used assuch in the next reaction.

Exo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic aciddiethylamide, 2u

Using an adaptation of Procedure 25, substitutingexo-3-(3-diethylcarbamoyl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1u forendo-3-(3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 4j, and using a 25% solution of TFA in methylenechloride instead of neat TFA, the title compoundexo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic aciddiethylamide, 2u was obtained as a TFA salt after purification viareverse phase HPLC (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 392.1.

Exo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 3u

Using an adaptation of Procedure 9, and substitutingexo-10-(8-aza-bicyclo-[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic aciddiethylamide, 2u forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, phenyl acetaldehyde for 2-pyridyl carboxaldehyde, tetrabutylammoniumtriacetoxy-borohydride for sodium triacetoxyborohydride, andtetrahydrofuran for dichloro-ethane, the title compoundexo-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 3u was obtained as a TFA salt after purification viareverse phase HPLC (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺)

Exo-10-(8-Pyridin-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 4u

Using an adaptation of Procedure 9, and substitutingexo-10-(8-aza-bicyclo-[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic aciddiethylamide, 2u forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, 3-pyridyl carboxaldehyde for 2-pyridyl carboxaldehyde,tetrabutylammonium triacetoxy-borohydride for sodiumtriacetoxyborohydride, and tetrahydrofuran for dichloro-ethane, thetitle compoundexo-10-(8-pyridin-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 4u was obtained as a TFA salt after purification viareverse phase HPLC (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 483.1.

Exo-10-(8-Thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 5u

Using an adaptation of Procedure 9, and substitutingexo-10-(8-aza-bicyclo-[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic aciddiethylamide, 2u forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, thiophene-2-carboxaldehyde for 2-pyridyl carboxaldehyde,tetrabutylammonium triacetoxyborohydride for sodiumtriacetoxyborohydride, and tetrahydrofuran for dichloroethane, the titlecompoundexo-10-(8-thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 5u was obtained as a TFA salt after purification viareverse phase HPLC (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 488.1.

Exo-10-[8-(3-Methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenoxazine-3-carboxylicacid diethylamide, 6u

Using an adaptation of Procedure 9, and substitutingexo-10-(8-aza-bicyclo-[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic aciddiethylamide, 2u forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, 3-methyl-but-2-enyl carboxaldehyde for 2-pyridyl carboxaldehyde,tetrabutylammonium triacetoxyborohydride for sodiumtriacetoxyborohydride, and tetrahydrofuran for dichloroethane, the titlecompoundexo-10-[8-(3-methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenoxazine-3-carboxylicacid diethylamide, 6u was obtained as a TFA salt after purification viareverse phase HPLC (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 460.1.

Exo-10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 7u

Using an adaptation of Procedure 9, and substitutingexo-10-(8-aza-bicyclo-[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic aciddiethylamide, 2u forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, tetrabutylammonium triacetoxyborohydride for sodiumtriacetoxyborohydride, and tetrahydrofuran for dichloroethane, the titlecompoundexo-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 7u was obtained as a TFA salt after purification viareverse phase HPLC (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 483.1.

Exo-10-(8-Benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 8u

Using an adaptation of Procedure 9, and substitutingexo-10-(8-aza-bicyclo-[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic aciddiethylamide, 2u forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, benzaldehyde for 2-pyridyl carboxaldehyde, tetrabutylammoniumtriacetoxyborohydride for sodium triacetoxyborohydride, andtetrahydrofuran for dichloroethane, the title compoundexo-10-(8-benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 8u was obtained as a TFA salt after purification viareverse phase HPLC (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 482.1.

Exo-10-(8-Thiazol-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 9u

Using an adaptation of Procedure 9, and substitutingexo-10-(8-aza-bicyclo-[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic aciddiethylamide, 2u forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, thiazol-2-ylmethyl carboxaldehyde for 2-pyridyl carboxaldehyde,tetrabutylammonium triacetoxyborohydride for sodiumtriacetoxyborohydride, and tetrahydrofuran for dichloroethane, the titlecompoundexo-10-(8-thiazol-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 9u was obtained as a TFA salt after purification viareverse phase HPLC (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 489.1.

Exo-10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 10u

Using an adaptation of Procedure 9, and substitutingexo-10-(8-aza-bicyclo-[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic aciddiethylamide, 2u forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, thiazol-2-ylmethyl carboxaldehyde for 2-pyridyl carboxaldehyde,tetrabutylammonium triacetoxyborohydride for sodiumtriacetoxyborohydride, and tetrahydrofuran for dichloroethane, the titlecompoundexo-10-(8-furan-3-ylmethyl-8-aza-bicyclo[3.2.1]-oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 10u was obtained as a TFA salt after purification viareverse phase HPLC (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 472.1.

Exo-10-[8-(1H-Imidazol-2-ylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenoxazine-3-carboxylicacid diethylamide, 11 u

Using an adaptation of Procedure 9, and substitutingexo-10-(8-aza-bicyclo-[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic aciddiethylamide, 2u forendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine,5b, 1H-imidazol-2-ylmethyl carboxaldehyde for 2-pyridyl carboxaldehyde,tetrabutylammonium triacetoxyborohydride for sodiumtriacetoxyborohydride, and tetrahydrofuran for dichloroethane, the titlecompoundxxo-10-[8-(1H-imidazol-2-ylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenoxazine-3-carboxylicacid diethylamide, 11u was obtained as a TFA salt after purification viareverse phase HPLC (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(M H⁺) 472.1.

Example V

Endo-3-(3-Chloro-6-methoxy-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1v

Using an adaptation of Procedure 2, and substituting6-fluoro-2-methoxy-nitrobenzene, 1e for 4-fluoro-3-nitrobenzonitrile andendo-3-(4-chloro-2-hydroxy-phenylamino)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1j for the TFA salt of3-hydroxy-4-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-ylamino)-benzoic acidmethyl ester, 1a, the title compoundendo-3-(3-chloro-6-methoxy-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1v was obtained. MS m/z (MH⁺) 457.2.

Endo-3-(6-Methoxy-3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2v

Using an adaptation of the method described in Procedure 24,substitutingendo-3-(3-chloro-6-methoxy-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1v forendo-3-(3-chlorophenoxazin-10-yl)-8-aza-bicyclo[3.2.1]-octane-8-carboxylicacid tert-butyl ester, 3j, the title compoundendo-3-(6-methoxy-3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2v was obtained. MS m/z (MH⁺) 500.3.

Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-7-pyridin-3-yl-10H-phenoxazin-4-ol,3v

Using an adaptation of the method described in Procedure 16,substitutingendo-3-(6-methoxy-3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2v for the TFA salt of6-methoxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 6e, the title compoundendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-7-pyridin-3-yl-10H-phenoxazin-4-ol,3v was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 386.1.

Endo-7-Pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-4-ol,4v

Using an adaptation of the method described in Procedure 1, substitutingthe TFA salt ofendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-7-pyridin-3-yl-10H-phenoxazin-4-ol,3v for 4-amino-3-hydroxybenzoic acid methyl ester, and 2-pyridylcarboxaldehyde for 8-methyl-8-aza-bicyclo[3.2.1]octan-3-one, the titlecompoundendo-7-pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-4-ol,4v was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 477.2.

Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-chloro-6-methoxy-10H-phenoxazine, 5v

Using an adaptation of the method described in Procedure 25,substituting the TFA salt ofendo-7-pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-4-ol,4v forendo-3-(3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 4j, the title compoundendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-chloro-6-methoxy-10H-phenoxazine,5v was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 357.1.

Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-3-pyridin-3-yl-10H-phenoxazine,6v

Using an adaptation of the method described in Procedure 25,substitutingendo-3-(6-methoxy-3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2v forendo-3-(3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 4j, the title compoundendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-3-pyridin-3-yl-10H-phenoxazine,6v was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 400.2.

Endo-6-Methoxy-3-pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine,7v

Using an adaptation of the method described in Procedure 1, substitutingendo-3-(6-methoxy-3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 2v for 4-amino-3-hydroxybenzoic acid methylester, and 2-pyridyl carboxaldehyde for8-methyl-8-aza-bicyclo[3.2.1]octan-3-one, the title compoundendo-6-methoxy-3-pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine,7v was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 491.2.

Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-7-pyridin-4-yl-10H-phenoxazin-4-ol,8v

Using an adaptation of the methods described in Procedures 24 and 16,substitutingendo-3-(3-chloro-6-methoxy-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1v forendo-3-(3-chlorophenoxazin-10-yl)-8-aza-bicyclo[3.2.1]-octane-8-carboxylicacid tert-butyl ester, 3j, and 4-pyridylboronic acid for3-pyridylboronic acid in Procedure 24, the title compoundendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-7-pyridin-4-yl-10H-phenoxazin-4-ol,8v was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 386.2.

Endo-7-Pyridin-4-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-4-ol,9v

Using an adaptation of the method described in Procedure 1, substitutingthe TFA salt ofendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-7-pyridin-4-yl-10H-phenoxazin-4-ol,8v for 4-amino-3-hydroxybenzoic acid methyl ester, and 2-pyridylcarboxaldehyde for 8-methyl-8-aza-bicyclo[3.2.1]octan-3-one, the titlecompoundendo-7-pyridin-4-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-4-ol,9v was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 477.3.

Endo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-7-pyridin-4-yl-10H-phenoxazin-4-ol,10v

Using an adaptation of the method described in Procedure 1, substitutingthe TFA salt ofendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-7-pyridin-4-yl-10H-phenoxazin-4-ol,8v for 4-amino-3-hydroxybenzoic acid methyl ester, and phenylacetaldehyde for 8-methyl-8-aza-bicyclo[3.2.1]octan-3-one, the titlecompoundendo-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-7-pyridin-4-yl-10H-phenoxazin-4-ol,10v was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 490.3.

Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-3-pyridin-4-yl-10H-phenoxazine,11v

Using an adaptation of the methods described in Procedures 24 and 25,substitutingendo-3-(3-chloro-6-methoxy-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1v forendo-3-(3-chlorophenoxazin-10-yl)-8-aza-bicyclo[3.2.1]-octane-8-carboxylicacid tert-butyl ester, 3j, and 4-pyridylboronic acid for3-pyridylboronic acid in Procedure 24, the title compoundendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-3-pyridin-4-yl-10H-phenoxazine,11v was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 400.2.

Endo-6-Methoxy-3-pyridin-4-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine,12v

Using an adaptation of the method described in Procedure 1, substitutingthe TFA salt ofendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-3-pyridin-4-yl-10H-phenoxazine,11v for 4-amino-3-hydroxybenzoic acid methyl ester, and 2-pyridylcarboxaldehyde for 8-methyl-8-aza-bicyclo[3.2.1]octan-3-one, the titlecompoundendo-6-methoxy-3-pyridin-4-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine,12v was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 491.2.

Endo-6-Methoxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine,13v

Using an adaptation of the method described in Procedure 1, substitutingthe TFA salt ofendo-10-(8-aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-3-pyridin-4-yl-10H-phenoxazine,11v for 4-amino-3-hydroxybenzoic acid methyl ester, and phenylacetaldehyde for 8-methyl-8-aza-bicyclo[3.2.1]octan-3-one, the titlecompoundendo-6-methoxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine,13v was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 504.3.

Example X

Endo-3-[3-(2-Acetylaminophenyl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1x

Using an adaptation of the method described in Procedure 24,substitutingN-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetamidefor 3-pyridyl boronic acid, the title compoundendo-3-[3-(2-acetylaminophenyl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1x was obtained as a TFA salt after purificationvia reverse phase chromatography (eluent: CH₃CN in water containing 0.1%TFA).

Endo-N-{2-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-phenyl}-acetamide,2x

Using an adaptation of Procedure 25, substituting the TFA salt ofendo-3-[3-(2-acetylaminophenyl)-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1x forendo-3-(3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 4j, the title compoundendo-N-{2-[10-(8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-phenyl}-acetamide,2x was obtained as a TFA salt after purification via reverse phase HPLC(eluent: CH₃CN in water containing 0.1% TFA). MS m/z (MH⁺) 426.2.

Endo-N-{2-[10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-phenylyacetamide,3x

Using an adaptation of the method described in Procedure 1, substitutingthe TFA salt ofendo-N-{2-[10-(8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-phenyl}-acetamide,2x for 4-amino-3-hydroxybenzoic acid methyl ester, and phenylacetaldehyde for 8-methyl-8-aza-bicyclo[3.2.1]octan-3-one, the titlecompoundendo-N-{2-[10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-phenyl}-acetamide,3x was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 530.3.

Endo-N-{2-[10-(8-Thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-phenyl}-acetamide,4x

Using an adaptation of the method described in Procedure 1, substitutingthe TFA salt ofendo-N-{2-[10-(8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-phenyl}-acetamide,2x for 4-amino-3-hydroxybenzoic acid methyl ester, and 2-thiophenecarboxaldehyde for 8-methyl-8-aza-bicyclo[3.2.1]octan-3-one, the titlecompoundendo-N-{2-[10-(8-thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-phenyl}-acetamide,4x was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 522.2.

Endo-N-{2-[10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenoxazin-3-yl]-phenylyacetamide,5x

Using an adaptation of the method described in Procedure 1, substitutingthe TFA salt ofendo-N-{2-[10-(8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-phenyl}-acetamide,2x for 4-amino-3-hydroxybenzoic acid methyl ester, and 2-pyridylcarboxaldehyde for 8-methyl-8-aza-bicyclo[3.2.1]octan-3-one, the titlecompoundendo-N-{2-[10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-phenyl}-acetamide,5x was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 517.2.

Example Y

Exo-N-{2-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-phenyl}-acetamide,1y

Using an adaptation of the methods described in Procedures 24 and 25,and substitutingexo-3-(3-chlorophenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1l forendo-3-(3-chlorophenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3j, andN-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetamidefor 3-pyridyl boronic acid in Procedure 24, the title compoundexo-N-{2-[10-(8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-phenyl}-acetamide,1y was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 426.2.

Example Z

Endo-3-[3-(2-Acetylaminophenyl)-6-methoxy-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1z

Using an adaptation of the method described in Procedure 24,substitutingN-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetamidefor 3-pyridyl boronic acid, the title compoundendo-3-[3-(2-acetylaminophenyl)-6-methoxy-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1z was obtained as a TFA salt after purificationvia reverse phase chromatography (eluent: CH₃CN in water containing 0.1%TFA).

Endo-N-{2-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-hydroxy-10H-phenoxazin-3-yl]-phenyl}-acetamide,2z

Using an adaptation of the method described in Procedure 16,substituting the TFA salt ofendo-3-[3-(2-acetylaminophenyl)-6-methoxy-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1z for the TFA salt of6-methoxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 6e, the title compoundendo-N-{2-[10-(8-aza-bicyclo[3.2.1]oct-3-yl)-6-hydroxy-10H-phenoxazin-3-yl]-phenyl}-acetamide,2z was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 442.2.

Endo-N-{2-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-10H-phenoxazin-3-yl]-phenylyacetamide,3z

Using an adaptation of the method described in Procedure 25,substituting the TFA salt ofendo-3-[3-(2-acetylaminophenyl)-6-methoxy-phenoxazin-10-yl]-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 1z forendo-3-(3-pyridin-3-yl-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 4j, the title compoundendo-N-{2-[10-(8-aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-10H-phenoxazin-3-yl]-phenyl}-acetamide,3z was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA). MS m/z(MH⁺) 456.2.

Example AA

Procedure 2810-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carbonitrile, 1aa

To a solution of10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-bromo-10H-phenothiazine, 4i (50 mg,0.13 mmol) in DMF (750 μL) was added zinc cyanide (15 mg, 0.13 mmol) andtetrakistriphenylphosphine palladium (4 mg), the solution was purgedwith nitrogen, and the mixture was heated in the microwave for 5 min at160° C. The mixture was allowed to cool to rt, and purified via reversephase HPLC (eluent: CH₃CN in water containing 0.1% TFA) to yield titlecompound10-(8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carbonitrile, 1aaas a TFA salt and as a mixture of endo and exo isomers. MS m/z (MH⁺)334.1.

10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carbonitrile,2aa

Using an adaptation of the method described in Procedure 22,substituting the TFA salt of10-(8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carbonitrile, 1aafor 3-bromo-10-piperidin-4-yl-10H-phenothiazine, 4i, the title compound10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carbonitrile,2aa was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA) and as amixture of endo and exo isomers.

Procedure 2910-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenothiazine,3aa

To a solution of10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carbonitrile,2aa (10 mg, 29 μmol) in dimethoxyethane was added trimethylsilyl azide(15 μL, 115 μmol) and dibutyltin oxide (1.5 mg), and the mixture washeated in a microwave for 15 min at 150° C. The mixture was allowed tocool to rt, and purified via reverse phase HPLC (eluent: CH₃CN in watercontaining 0.1% TFA) to yield title compound10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenothiazine,3aa as a TFA salt and as a mixture of endo and exo isomers. MS m/z (MH⁺)481.2.

10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenothiazine,4aa

Using an adaptation of the methods described in Procedures 22 and 29,substituting the TFA salt of10-(8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carbonitrile, 1aafor 3-bromo-10-piperidin-4-yl-10H-phenothiazine, 4i and 2-pyridylcarboxaldehyde for 3-furyl carboxaldehyde in Procedure 22, the titlecompound10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenothiazine,4aa was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA) and as amixture of endo and exo isomers. MS m/z (MH⁺) 468.2.

10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenothiazine,5aa

Using an adaptation of the method described in Procedure 29,substituting the TFA salt of10-(8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carbonitrile, 1aafor10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carbonitrile,2aa, the title compound10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenothiazine,5aa was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA) and as amixture of endo and exo isomers.

MS m/z (MH⁺) 377.2.

N,N-Diethyl-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carboxamidine,6aa

Using an adaptation of the method described in Procedure 10,substituting the TFA salt of10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carbonitrile,2aa forendo-3-(3-cyano-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3b, the title compoundN,N-diethyl-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carboxamidine,6aa was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA) and as amixture of endo and exo isomers. MS m/z (MH⁺) 511.3.

N,N-Diethyl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carboxamidine,7aa

Using an adaptation of the methods described in Procedures 22 and 10,substituting the TFA salt of10-(8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carbonitrile, 1aaforendo-3-(3-cyano-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3b, and 2-pyridyl carboxaldehyde for 3-furylcarboxaldehyde, the title compoundN,N-diethyl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carboxamidine,7aa was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA) and as amixture of endo and exo isomers.

MS m/z (MH⁺) 498.3.

Example BB

10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carbonitrile,1bb

Using an adaptation of the method described in Procedure 28,substituting3-bromo-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine, 3iforendo-3-(3-cyano-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3b, the title compound10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carbonitrile,1bb was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA) and as amixture of endo and exo isomers. MS m/z (MH⁺) 348.1.

10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenothiazine,2bb

Using an adaptation of the method described in Procedure 29,substituting the TFA salt of10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carbonitrile,1bb for10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carbonitrile,2aa, the title compound10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenothiazine,2bb was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA) and as amixture of endo and exo isomers.

MS m/z (MH⁺) 391.1.

N,N-Diethyl-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carboxamidine,3bb

Using an adaptation of the method described in Procedure 10,substituting the TFA salt of10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carbonitrile,1bb forendo-3-(3-cyano-phenoxazin-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester, 3b, the title compoundN,N-diethyl-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carboxamidine,3bb was obtained as a TFA salt after purification via reverse phasechromatography (eluent: CH₃CN in water containing 0.1% TFA) and as amixture of endo and exo isomers. MS m/z (MH⁺) 421.2.

Example CC

Spiro Compound, 1cc

Using an adaptation of the method described in Procedure 18,substituting for 2-amino-5-bromothiophenol for 2-aminothiophenol, thetitle compound 1cc was obtained.

[2-(3-Methoxy-2-nitro-phenylsulfanyl)-phenyl]-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amine,2cc

Using an adaptation of the method described in Procedure 19,substituting spiro compound, 1cc for spiro compound 1i, the titlecompound[2-(3-methoxy-2-nitro-phenylsulfanyl)-phenyl]-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amine,2cc was obtained a mixture of endo and exo isomers.

3-Bromo-6-methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine,3cc

Using an adaptation of the method described in Procedure 20,substituting[2-(3-methoxy-2-nitro-phenylsulfanyl)-phenyl]-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amine,2cc for[2-(4-bromo-2-nitrophenylsulfanyl)-phenyl]-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amine,2i, the title compound3-bromo-6-methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine,3cc was obtained a mixture of endo and exo isomers.

10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-bromo-6-methoxy-10H-phenothiazine,4cc

Using an adaptation of the method described in Procedure 21,substituting3-bromo-6-methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine3cc for3-bromo-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine,3i, the title compound10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-bromo-6-methoxy-10H-phenothiazine,4cc was obtained a mixture of endo and exo isomers.

10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-7-bromo-10H-phenothiazin-4-ol, 5cc

Using an adaptation of the method described in Procedure 16,substituting10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-bromo-6-methoxy-10H-phenothiazine,4cc for6-methoxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 6e, a mixture of title compound10-(8-aza-bicyclo-[3.2.1]oct-3-yl)-7-bromo-10H-phenothiazin-4-ol, 5ccand starting material10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-bromo-6-methoxy-10H-phenothiazine,4cc was obtained a mixture of endo and exo isomers.

10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-3-pyridin-3-yl-10H-phenothiazine,6cc and10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-7-pyridin-3-yl-10H-phenothiazin-4-ol,7cc

Using an adaptation of the method described in Procedure 23,substituting a mixture of10-(8-aza-bicyclo[3.2.1]oct-3-yl)-3-bromo-6-methoxy-10H-phenothiazine,4cc and10-(8-aza-bicyclo-[3.2.1]oct-3-yl)-7-bromo-10H-phenothiazin-4-ol, 5ccfor3-bromo-10-(8-furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine,5i, a mixture of title compounds10-(8-aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-3-pyridin-3-yl-10H-phenothiazine,6cc and10-(8-aza-bicyclo[3.2.1]oct-3-yl)-7-pyridin-3-yl-10H-phenothiazin-4-ol,7cc was obtained. The compounds were separated via reverse phase HPLC(eluent: CH3CN in water containing 0.1% TFA) to yield 6cc [MS m/z (MH⁺)416.2] and 7cc [MS m/z (MH⁺) 402.2], bothy as TFA salts and mixtures ofendo and exo isomers.)

Example DD

6-Methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carboxylicacid diethylamide, 1dd

Using an adaptation of the method described in Procedure 26,substituting a mixture of endo and exo isomers of3-bromo-6-methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine,3cc for 3-bromo-10-piperidin-4-yl-10H-phenothiazine, 4i, title compound6-methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-carboxylicacid diethylamide, 1dd was obtained as a mixture of endo and exoisomers.

10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-10H-phenothiazine-3-carboxylicacid diethylamide, 2dd

Using an adaptation of the method described in Procedure 21,substituting3-bromo-6-methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine,3cc for3-bromo-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine,3i, title compound10-(8-aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-10H-phenothiazine-3-carboxylicacid diethylamide, 2dd was obtained as a TFA salt and as a mixture ofendo and exo isomers.

10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-hydroxy-10H-phenothiazine-3-carboxylicacid diethylamide, 3dd

Using an adaptation of the method described in Procedure 16,substituting10-(8-aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-10H-phenothiazine-3-carboxylicacid diethylamide, 2dd for6-methoxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide, 6e, a mixture of title compound10-(8-aza-bicyclo[3.2.1]oct-3-yl)-6-hydroxy-10H-phenothiazine-3-carboxylicacid diethylamide, 3dd was obtained. MS m/z (MH⁺) 424.2.

Biological Examples Rat Brain Delta Opioid Receptor Binding Assay

Procedure: Male, Wistar rats (150-250 g, VAF, Charles River, Kingston,N.Y.) were killed by CO₂, and their brains were removed and placedimmediately in ice cold Tris HCl buffer (50 mM, pH 7.4). The forebrainswere separated from the remainder of the brain by a coronal transection,beginning dorsally at the colliculi and passing ventrally through themidbrain-pontine junction. After dissection, the forebrains werehomogenized in Tris buffer in a Teflon®-glass homogenizer. Thehomogenate was diluted to a concentration of 1 g of forebrain tissue per80 mL Tris and centrifuged at 39,000×g for 10 min. The pellet wasresuspended in the same volume of Tris buffer containing 5 mM MgCl₂ withseveral brief pulses from a Polytron homogenizer. This particulatepreparation was used for the delta opioid binding assays. Followingincubation with the delta selective peptide ligand ˜4 nM [³H]DPDPE or0.15 nM [³H]naltrindole at 25° C. for 2.5 h in a 96-well plate withtotal volume of 1 mL, the plate contents were filtered through Wallacfiltermat B sheets on a Tomtec 96-well harvester. The filters wererinsed three times with 2 mL of 10 mM HEPES (pH 7.4), and dried in a 650W microwave oven for 1.75 min twice. To each sample area 2×50 μL ofBetaplate Scint scintillation fluid (LKB) was added and theradioactivity quantified on a LKB (Wallac) 1205 BetaPlate liquidscintillation counter.

Analysis: The data from the scintillation counter were used to calculateeither the % inhibition compared to control binding (when only a singleconcentration of test compound was evaluated) or a K_(i) value (when arange of concentrations was tested). Percent inhibition was calculatedas: [(total dpm-test compound dpm)/(total dpm-nonspecific dpm)]*100. Kdand Ki values were calculated using GraphPad PRISM data analysisprogram.

Rat Brain Mu Opioid Receptor Binding Assay

Procedure: Male, Wistar rats (150-250 g, VAF, Charles River, Kingston,N.Y.) were killed by CO₂, and their brains were removed and placedimmediately in ice cold Tris HCl buffer (50 mM, pH 7.4). The forebrainswere separated from the remainder of the brain by a coronal transection,beginning dorsally at the colliculi and passing ventrally through themidbrain-pontine junction. After dissection, the forebrains werehomogenized in Tris buffer in a Teflon®-glass homogenizer. Thehomogenate was diluted to a concentration of 1 g of forebrain tissue per80 mL Tris and centrifuged at 39,000×g for 10 min. The pellet wasresuspended in the same volume of Tris buffer containing 5 mM MgCl₂ withseveral brief pulses from a Polytron homogenizer. This particulatepreparation was used for the delta opioid binding assays. Followingincubation with the mu selective peptide ligand, ˜0.8 nM [³H]DAMGO, at25° C. for 2.5 h in a 96-well plate with total assay volume of 1 mL, theplate contents were filtered through Wallac filtermat B sheets on aTomtec 96-well harvester. The filters were rinsed three times with 2 mLof 10 mM HEPES (pH 7.4), and dried in a 650 W microwave oven for 1.75min twice. To each sample area 2×40 μL of Betaplate Scint scintillationfluid (LKB) was added and the radioactivity quantifed on a LKB (Wallac)1205 BetaPlate liquid scintillation counter.

Analysis: The data from the scintillation counter were used to calculateeither the % inhibition compared to control binding (when only a singleconcentration of test compound was evaluated) or a K₁ value (when arange of concentrations tested). Percent inhibition was calculated as:[(total dpm-test compound dpm)/(total dpm-nonspecific dpm)]*100. Kd andKi values were calculated using GraphPad PRISM data analysis program.

[³⁵S]GTPγS Binding Assay in NG108-15 Cell Membranes (delta opioid)

Methods: NG108-15 cell membranes can be purchased from Applied CellSciences (Rockville, Md.). 8 mg/mL of membrane protein suspended in 10mM TRIS-HCl pH 7.2, 2 mM EDTA, 10% sucrose. Membranes can be maintainedat 4-8° C. A 1 mL volume of membranes can be added into 10 mL coldbinding assay buffer. The assay buffer contained 50 mM Tris, pH 7.6, 5mM MgCl₂, 100 mM NaCl, 1 mM DTT and 1 mM EGTA. The membrane suspensioncan be homogenized twice with a Polytron, and centrifuged at 3000 rpmfor 10 min. The supernatant can be then centrifuged at 18,000 rpm for 20min. Ten mL assay buffer can be added into the pellet containing tube.The pellet and buffer can be mixed with a Polytron.

Incubation procedure: The pellet membranes (75 μg/mL) can bepreincubated with SPA (10 mg/mL) at 25° C. for 45 min in the assaybuffer. The SPA (5 mg/mL) coupled with membranes (37.5 μg/mL) can thenbe incubated with 0.1 nM [³⁵3] GTPγS in the same Tris buffer containing100 μM GDP in total volume of 200 μL. Increasing concentrations ofreceptor agonists can be used to stimulate [³⁵5]-GTP S binding. Thebasal binding can be tested in the absence of agonists and non-specificbinding can be tested in the presence of 10 μM unlabeled GTPγS. The datacan be analyzed on a Packard Top Count. DATA

-   % of Basal=(stimulated—non specific)*100/(basal—non specific).-   EC₅₀ value values can be calculated using GraphPad Prism.

[³⁵S]GTPγS Binding Assays in CHO-hMOR Cell Membranes

Methods: CHO-hMOR cell membranes can be purchased from Receptor Biology,Inc. (Baltimore, Md.). About 10 mg/mL of membrane protein can besuspended in 10 mM TRIS-HCl pH 7.2, 2 mM EDTA, 10% sucrose, and thesuspension kept on ice. A 1 mL volume of membranes can be added to 15 mLcold binding assay buffer containing 50 mM HEPES, pH 7.6, 5 mM MgCl₂,100 mM NaCl, 1 mM DTT and 1 mM EDTA. The membrane suspension can behomogenized with a Polytron and centrifuged at 3,000 rpm for 10 min. Thesupernatant can then be centrifuged at 18,000 rpm for 20 min. The pelletcan be resuspended in 10 mL assay buffer with a Polytron. The membranescan be preincubated with wheat germ agglutinin coated SPA beads(Amersham) at 25° C. for 45 min in the assay buffer. The SPA bead (5mg/mL) coupled membranes (10 μg/mL) can be then incubated with 0.5 nM[³⁵S]GTPγS in the assay buffer. The basal binding can be that takingplace in the absence of added test compound; this unmodulated bindingcan be considered as 100%, with agonist stimulated binding rising tolevels significantly above this value. A range of concentrations ofreceptor agonist can be used to stimulate [³⁵S]GTPγS binding. Both basaland non-specific binding can be tested in the absence of agonist;non-specific binding determination included 10 μM unlabeled GTPγS.

Compounds can be tested for function as antagonists by evaluating theirpotential to inhibit agonist-stimulated GTPγS binding. Radioactivity canbe quantified on a Packard TopCount. The following parameters can becalculated:

${\% \mspace{14mu} {stimulation}} = {\frac{\left( {{{test}\mspace{14mu} {compound}\mspace{14mu} {cpm}} - {{non}\text{-}{specific}\mspace{14mu} {cpm}}} \right)}{\left( {{{basal}\mspace{14mu} {cpm}} - {{non}\text{-}{specific}\mspace{14mu} {cpm}}} \right)} \times 100.}$${\% \mspace{14mu} {inhibition}} = {\frac{\begin{pmatrix}{{\% \mspace{14mu} {stimulation}\mspace{14mu} {by}\mspace{14mu} 1\mspace{14mu} {µM}\mspace{14mu} {DAMGO}} -} \\{\% \mspace{14mu} {stimulation}\mspace{14mu} {by}\mspace{14mu} {test}\mspace{14mu} {compound}}\end{pmatrix}}{\left( {{\% \mspace{14mu} {stimulation}\mspace{14mu} {by}\mspace{14mu} 1\mspace{14mu} {µM}\mspace{14mu} {DAMGO}} - 100} \right)} \times 100}$

-   EC₅₀ values can be calculated using Graph Pad Prism.

Biological Data Compound Number delta (Ki, nM) mu (Ki, nM) 4t 0.1 4aa0.1 6b 0.1 168.45 6d 0.1 336 9t 0.10 8t 0.18 4v 0.3 2z 0.62 10t 1.14 7e2.2 7t 2.43 7u 3.27 8v 5.2 3v 8.3 8j 18.8 8u 20.70 3t 25.1 3z 27.63 12v36.3 6u 44.49 3c 48.1 525 7v 56.6 5t 56.7 5x 81.82 2t 86.6 6e 99.5 7j103.6 7i 122.84 554.3 9v 136.3 4x 161.3 2u 196.5 6t 231.0 5k 246.7 6v263.2 6i 282.35 1055.7 4e 320.9 5aa 321.1 11i 366.9 170.985 4a 373 67613r 396.8 682.2 11v 399.5 5b 406 6849 5j 409.4 2x 414.6 4l 424.6 8i 443.5889.4 4k 444.8 5u 477.80 3m 480.1 12i 491.45 1450 2c 492 9448 5l 539.24u 542.55 13i 551.6 3740 6a 575 819 2h 598 2889 17i 629 1533.5 15i629.55 168.9 2m 634.2 9i 649.35 538.4 1r 651.95 2758 2k 695.5 2a 6975152 3l 729.1 2r 863.65 4340 4p 864.5 4m 868.9 4i 881 6613 1aa 930.9 18i940.75 8073 10i 949.05 317.3 6l 1269.1 5m 1278.5 3u 1356.30 16i 14532654 3x 1585.0 1y 1601.8 14i 1603.5 598.75 3f 1752 1435 8b 1896 >100001g 2041 4285 5a 2116 6091 5v 2260.0 3i 2532 3185 7d 2633 123 2f 2644.52752 4c 3106 89.0 6j 3261.5 3k 3388.0 3p 5123.0 19i 5191 254 7b 5475 2887l 6211.5 9j 11865.0 10j 13321.5 6k 14223.5 10v >10000 13v >10000

1. A method of providing analgesia comprising administering to a patienta compound of Formula (I):

wherein: G is —C(Z)N(R₁)R₂, C₆₋₁₀aryl, or a heterocycle selected fromthe group consisting of imidazolyl, triazolyl, tetrazolyl, oxadiazolyl,thiadiazolyl, oxathiadiazolyl, imidazolinyl, tetrahydropyrimidinyl,thienyl, pyrazolyl, pyrimidinyl, triazinyl, furyl, indazolyl, indolyl,indolinyl, isothiazolyl, isoxazolyl, oxazolyl, isoxadiazolyl,benzoxazolyl, quinolinyl, isoquinolinyl, and pyridinyl; wherein aryl andthe heterocycles of G are optionally substituted with one to threesubstituents independently selected from the group consisting ofC₁₋₈alkanyl, C₂₋₈alkenyl, C₂₋₈alkynyl, C₁₋₈alkanyloxy,hydroxy(C₁₋₈)alkanyl, carboxy(C₁₋₈)alkanyl, C_(1-g)alkanylcarbonylamino,halogen, hydroxy, cyano, nitro, oxo, thioxo, amino, C₁₋₆alkanylamino,di(C₁₋₆alkanyl)amino, C₁₋₈alkanylthio, C₁₋₈alkanylsulfonyl,C₁₋₈alkanylsulfonylamino, aminocarbonyl, aminothiocarbonyl,aminocarbonylamino, aminothiocarbonylamino, C₁₋₈alkanylaminocarbonyl,di(C₁₋₈alkanyl)aminocarbonyl, and C₁₋₆alkanyloxycarbonylamino; R₁ is asubstituent selected from the group consisting of hydrogen, C₁₋₈alkanyl,C₂₋₈alkenyl, and C₂₋₈alkynyl; R₂ is a substituent selected from thegroup consisting of hydrogen; C₁₋₈alkanyl; C₂₋₈alkenyl; C₂₋₈alkynyl;C₆₋₁₀aryl; and C₁₋₈cycloalkanyl; wherein C₁₋₈alkanyl is optionallysubstituted with one to three substituents independently selected fromthe group consisting of phenyl, amino, C₁₋₆ alkanylamino, di(C₁₋₆alkanyl)amino, C₁₋₆ alkanyloxy, thioC₁₋₆alkanyloxy, hydroxy, fluoro,chloro, cyano, aminocarbonyl, C₁ ₋₈ alkanylaminocarbonyl, di(C₁₋₈alkanyl)aminocarbonyl, C₁₋₆alkanyloxycarbonyl, and aryloxy; and whereinany aryl-containing substituents and C₁₋₈cycloalkanyl substituents of R₂are optionally substituted with one to three substituents independentlyselected from the group consisting of C₁₋₈alkanyl, C₂₋₈alkenyl,C₂₋₈alkynyl, C₁₋₈alkanyloxy, trifluoromethyl, trifluoromethoxy, phenyl,halogen, cyano, hydroxy, C₁₋₈ alkanylthio, C₁₋₈ alkanylsulfonyl, andC₁₋₈alkanylsulfonylamino; or R₁ and R₂ taken together with the nitrogento which they are attached form a 5-7 membered cycloheteroalkyloptionally substituted with one to three substituents independentlyselected from the group consisting of C₁₋₈alkanyl, hydroxy(C₁₋₈)alkanyl,hydroxy, amino, C₁₋₆alkanylamino, di(C₁₋₆ alkanyl)amino, and halogen; R₃is a substituent selected from the group consisting of hydrogen,C₁₋₈alkanyl, halo₁₋₃(C₁₋₈)alkanyl, C₂₋₈alkenyl, C₂₋₈alkynyl, C₃₋₈cycloalkanyl, cycloalkanyl(C₁₋₈)alkanyl, C₁ ₋₈alkanyloxy(C₁₋₈)alkanyl,C₁₋₈ alkanylthio(C₁₋₈)alkanyl, hydroxyC₁ ₋₈alkanyl,C₁₋₈alkanyloxycarbonyl, halo₁₋₃(C₁₋₈)alkanylcarbonyl, formyl,thioformyl, carbamimidoyl, phenylimino(C₁₋₈)alkanyl,phenyl(C₁₋₈)alkanyl, phenyl(C₁₋₈)alkenyl, phenyl(C₁₋₈)alkynyl,naphthyl(C₁₋₈)alkanyl and heteroaryl(C₁₋₈)alkanyl wherein the heteroarylis selected from the group consisting of benzo[1,3]dioxolyl, imidazolyl,furanyl, pyridinyl, thienyl, indazolyl, indolyl, indolinyl,isoindolinyl, isoquinolinyl, isothiazolyl, isoxazolyl, oxazolyl,pyrazinyl, pyrazolyl, pyridazinyl, pyrimidinyl, pyrrolyl, quinolinyl,isoquinolinyl, tetrazolyl, thiazolyl; wherein phenyl, naphthyl, andheteroaryl are optionally substituted with one to three substituentsindependently selected from the group consisting of C₁₋₆alkanyl, C₂₋₆alkenyl, C₁ ₋₆alkanyloxy, amino, C₁ ₋₆alkanylamino, di(C₁₋₆alkanyl)amino, C₁₋₆alkanylcarbonyl, C₁₋₆alkanylcarbonyloxy,C₁₋₆alkanylcarbonylamino, C₁₋₆alkanylthio, C₁₋₆alkanylsulfonyl, halogen,hydroxy, cyano, fluoro(C₁₋₆)alkanyl, thioureido, andfluoro(C₁₋₆)alkanyloxy; alternatively, when phenyl and heteroaryl areoptionally substituted with alkanyl or alkanyloxy substituents attachedto adjacent carbon atoms, the two substituents can together form a fusedcyclic alkanyl or cycloheteroalkanyl selected from the group consistingof —(CH₂)₃₋₅—, —O(CH₂)₂₋₄—, —(CH₂)₂₋₄O—, and —O(CH₂)₁₋₃O—; R₄ is one tothree substituents independently selected from the group consisting ofhydrogen; C₁₋₆alkanyl; C₂₋₆alkenyl; C₂₋₆alkynyl; aryl(C₂₋₆)alkynyl;C₁₋₆alkanyloxy; amino; C₁₋₆alkanylamino; di(C₁₋₆alkanyl)amino;C₆₋₁₀arylamino wherein C₆₋₁₀aryl is optionally substituted with one tothree substitutents independently selected from the group consisting ofC₁₋₆alkanyl, C₁₋₆alkoxy, halogen, and hydroxy; formylamino;pyridinylamino; C₁₋₆alkanylcarbonyl; C₁ ₋₆alkanylcarbonyloxy;C₁₋₆alkanyloxycarbonyl; aminocarbonyl; C₁₋₆alkanylaminocarbonyl;di(C₁₋₆alkanyl)aminocarbonyl; C₁ ₋₆alkanylcarbonylamino;C₁₋₆alkanylthio; C₁₋₆alkanylsulfonyl; halogen; hydroxy; cyano;hydroxycarbonyl; C₆₋₁₀aryl; chromanyl; chromenyl; furanyl; imidazolyl;indazolyl; indolyl; indolinyl; isoindolinyl; isoquinolinyl;isothiazolyl; isoxazolyl; naphthyridinyl; oxazolyl; pyrazinyl;pyrazolyl; pyridazinyl; pyridinyl; pyrimidinyl; pyrrolyl; quinazolinyl;quinolinyl; quinolizinyl; quinoxalinyl; tetrazolyl; thiazolyl; thienyl;fluoroalkanyl and fluoroalkanyloxy; or optionally; when R₄ is twosubstituents attached to adjacent carbon atoms, the two substituentstogether form a single fused moiety; wherein the fused moiety is—(CH₂)₃₋₅—, —O(CH₂)₂₋₄—, —(CH₂)₂₋₄O—, —O(CH₂)₁₋₃O—, or —S—C(NH₂)═N—; R₅is one to two substituents independently selected from the groupconsisting of hydrogen, C₁₋₆alkanyl, C₂₋₆alkenyl, C₁₋₆alkanyloxy, amino,C₁₋₆alkanylamino, di(C₁₋₆alkanyl)amino, C₁₋₆alkanylcarbonyl,C₁₋₆alkanylcarbonyloxy, C₁₋₆alkanyloxycarbonyl, C₁₋₆alkanylaminocarbonyl, C₁₋₆alkanylcarbonylamino, C₁₋₆alkanylthio,C₁₋₆alkanylsulfonyl, halogen, hydroxy, cyano, fluoro(C₁₋₆)alkanyl andfluoro(C₁₋₆)alkanyloxy; A is —(CH₂)_(m)—, wherein m is 2 or 3; Y is O; Zis O, S, NH, N(C₁₋₆alkanyl), N(OH), N(OC₁₋₆alkanyl), or N(phenyl); andenantiomers, diastereomers, tautomers, or pharmaceutically acceptablesalts thereof.
 2. The method according to claim 1 wherein G is—C(Z)N(R₁)R₂, phenyl, or a heterocycle selected from the groupconsisting of tetrazolyl, oxadizolyl, furyl, quinolinyl, thienyl, andpyridinyl; wherein phenyl and the heterocycles of G are optionallysubstituted with one to three substituents independently selected fromthe group consisting of C₁₋₈alkanyl, C₁₋₈alkanyloxy,ydroxyl(C₁₋₈)alkanyl, carboxy(C₁₋₈)alkanyl, C₁₋₈alkanylcarbonylamino,halogen, ydroxyl, cyano, oxo, thioxo, amino, C₁₋₆alkanylamino,di(C₁₋₆alkanyl)amino, C₁₋₈alkanylthio, aminocarbonyl, aminothiocarbonyl,C₁₋₈alkanylaminocarbonyl, di(C₁₋₈alkanyl)aminocarbonyl, andC₁₋₆alkanyloxycarbonylamino.
 3. The method according to claim 1 whereinG is —C(Z)N(R₁)R₂, phenyl, or a heterocycle selected from the groupconsisting of imidazolyl, triazolyl, tetrazolyl, oxadiazolyl,thiadiazolyl, oxathiadiazolyl, imidazolinyl, tetrahydropyrimidinyl,thienyl, pyrazolyl, pyrimidinyl, triazinyl, isothiazolyl, isoxazolyl,oxazolyl, isoxadiazolyl, and pyridinyl; wherein phenyl and theheterocycles of G are optionally substituted with one to threesubstituents independently selected from the group consisting ofC₁₋₈alkanyl, C₁₋₈alkanyloxy, ydroxyl(C₁₋₈)alkanyl, carboxy(C₁₋₈)alkanyl,C₁₋₈alkanylcarbonylamino, halogen, ydroxyl, cyano, oxo, thioxo, amino,C₁₋₆alkanylamino, di(C₁₋₆alkanyl)amino, C₁₋₈alkanylthio, aminocarbonyl,aminothiocarbonyl, C₁₋₈alkanylaminocarbonyl,di(C₁₋₈alkanyl)aminocarbonyl, and C₁₋₆alkanyloxycarbonylamino.
 4. Themethod according to claim 1 wherein G is —C(Z)N(R₁)R₂, phenyl, or aheterocycle selected from the group consisting of imidazolyl,tetrazolyl, oxadiazolyl, thiadiazolyl, oxathiadiazolyl, imidazolinyl,thienyl, pyrazolyl, pyrimidinyl, triazinyl, isothiazolyl, isoxazolyl,oxazolyl, isoxadiazolyl, and pyridinyl; wherein phenyl and theheterocycles of G are optionally substituted with one to threesubstituents independently selected from the group consisting ofC₁₋₄alkanyl, C₁₋₄alkanyloxy, ydroxyl(C₁₋₄)alkanyl, carboxy(C₁₋₄)alkanyl,C₁₋₄alkanylcarbonylamino, ydroxyl, cyano, oxo, thioxo, amino,C₁₋₆alkanylamino, di(C₁₋₆alkanyl)amino, C₁₋₈alkanylthio, aminocarbonyl,aminothiocarbonyl, C₁₋₈alkanylaminocarbonyl, anddi(C₁₋₈alkanyl)aminocarbonyl.
 5. The method according to claim 1 whereinG is —C(Z)N(R₁)R₂, phenyl, or a heterocycle selected from the groupconsisting of imidazolyl, tetrazolyl, oxadiazolyl, thiadiazolyl,oxathiadiazolyl, thienyl, isothiazolyl, isoxazolyl, isoxadiazolyl, andpyridinyl; wherein phenyl and the heterocycles of G are optionallysubstituted with one to three substituents independently selected fromthe group consisting of C₁₋₄alkanyl, C₁₋₄alkanyloxy,ydroxyl(C₁₋₄)alkanyl, C₁₋₄alkanylcarbonylamino, ydroxyl, cyano, oxo,thioxo, and aminocarbonyl.
 6. The method according to claim 1 wherein Gis —C(Z)N(R₁)R₂, phenyl, or a heterocycle selected from the groupconsisting of tetrazolyl, oxadizolyl, furyl, quinolinyl, thienyl, andpyridinyl; wherein phenyl and the heterocycles of G are optionallysubstituted with one to three substituents independently selected fromthe group consisting of C₁₋₄alkanyl, C₁₋₄alkanyloxy,ydroxyl(C₁₋₄)alkanyl, C₁₋₄alkanylcarbonylamino, ydroxyl, cyano, oxo,thioxo, and aminocarbonyl.
 7. The method according to claim 1 wherein Gis —C(Z)N(R₁)R₂, tetrazolyl, pyridinyl, oxadiazolyl optionallysubstituted with oxo, or phenyl optionally substituted with(C₁₋₈)alkanylcarbonylamino.
 8. The method according to claim 1 wherein Gis —C(Z)N(R₁)R₂, 1H-tetrazol-4-yl, 4H-[1,2,4]-oxadiazol-5-oxo-3-yl,2-methylcarbonylaminophenyl, pyridine-3-yl or pyridine-4-yl.
 9. Themethod according to claim 1 wherein R₁is a substituent selected from thegroup consisting of hydrogen and C₁₋₄alkanyl.
 10. The method accordingto claim 1 wherein R₁ is selected from the group consisting of hydrogen,methyl, ethyl, and propyl.
 11. The method according to claim 1 whereinR₁is selected from the group consisting of hydrogen, methyl, and ethyl.12. The method according to claim 1 wherein R₂ is selected from thegroup consisting of hydrogen; C₁₋₄alkanyl; phenyl; and C₁₋₆cycloalkanyl;wherein C₁₋₄alkanyl is optionally substituted with one to threesubstituents independently selected from the group consisting of phenyl,amino, C₁₋₆alkanylamino, di(C₁₋₆alkanyl)amino, C₁₋₄alkanyloxy, hydroxy,fluoro, chloro, cyano, aminocarbonyl, C₁₋₈alkanylaminocarbonyl,di(C₁₋₈alkanyl)aminocarbonyl, and phenoxy; and wherein anyphenyl-containing substituents and C₁₋₆cycloalkanyl substituents of R₂are optionally substituted with one to three substituents independentlyselected from the group consisting of C₁₋₈alkanyl, C₁₋₈alkanyloxy,trifluoromethyl, phenyl, fluoro, hydroxy, C₁₋₈alkanylthio,C₁₋₈alkanylsulfonyl, and C₁₋₈alkanylsulfonylamino; or R₁ and R₂ takentogether with the nitrogen to which they are attached form a 5-7membered cycloheteroalkyl optionally substituted with one to threesubstituents independently selected from the group consisting ofC₁₋₄alkanyl, hydroxy(C₁₋₄)alkanyl, hydroxy, amino, C₁₋₆alkanylamino,di(C₁₋₆alkanyl)amino, and fluoro.
 13. The method according to claim 1wherein R₂ is selected from the group consisting of hydrogen,C₁₋₄alkanyl, phenyl, and C₁₋₆cycloalkanyl; wherein C₁₋₄alkanyl isoptionally substituted with one to three substituents independentlyselected from the group consisting of phenyl, C₁₋₄alkanyloxy, hydroxy,fluoro, aminocarbonyl, C₁₋₈alkanylaminocarbonyl,di(C₁₋₈alkanyl)aminocarbonyl, and phenoxy; and wherein anyphenyl-containing substituent of R₂ is optionally substituted with oneto three substituents independently selected from the group consistingof C₁₋₆alkanyl, C₁₋₆alkanyloxy, fluoro, hydroxy, and C₁₋₆alkanylthio; orR₁ and R₂ taken together with the nitrogen to which they are attachedform a pyrrolidinyl or piperidinyl ring wherein said pyrrolidinyl orpiperidinyl is optionally substituted with a substituent selected fromthe group consisting of C₁₋₄alkanyl and hydroxy.
 14. The methodaccording to claim 1 wherein R₂ is selected from the group consisting ofhydrogen, C₁₋₄alkanyl and phenyl; wherein C₁₋₄alkanyl is optionallysubstituted with one to three substituents independently selected fromthe group consisting of phenyl, C₁₋₄alkanyloxy, hydroxy, fluoro, andphenoxy; and wherein any phenyl-containing substituent of R₂ isoptionally substituted with one to three substituents independentlyselected from the group consisting of C₁₋₆alkanyl, C₁₋₆alkanyloxy,fluoro, and hydroxy; or R₁ and R₂ taken together with the nitrogen towhich they are attached form a pyrrolidinyl or piperidinyl ring whereinsaid pyrrolidinyl or piperidinyl is optionally substituted with asubstituent selected from the group consisting of C₁₋₃alkanyl andhydroxy.
 15. The method according to claim 1 wherein R₂ is selected fromthe group consisting of hydrogen and C₁₋₄alkanyl; wherein C₁₋₄alkanyl isoptionally substituted with phenyl; or R₁ and R₂ taken together with thenitrogen to which they are attached form a pyrrolidinyl wherein saidpyrrolidinyl is optionally substituted with hydroxy.
 16. The methodaccording to claim 1 wherein R₂ is selected from the group consisting ofhydrogen, methyl, ethyl, and phenethyl; or R₁ and R₂ taken together withthe nitrogen to which they are attached form pyrrolidin-1-yl,3-hydoxypyrrolidin-1-yl or 3-(S)-hydoxypyrrolidin-1-yl.
 17. The methodaccording to claim 1 wherein R₃ is selected from the group consisting ofhydrogen, C₁₋₈alkanyl, C₂₋₈alkenyl, C₂₋₈alkynyl,C₁₋₈alkanyloxy(C₁₋₈)alkanyl, C₁₋₈alkanylthio(C₁₋₈)alkanyl,hydroxyC₁₋₈alkanyl, thioformyl, phenylimino(C₁₋₈)alkanyl,phenyl(C₁₋₈)alkanyl, and heteroaryl(C₁₋₈)alkanyl wherein heteroaryl isselected from the group consisting of benzo[1,3]dioxolyl, imidazolyl,furanyl, pyridinyl, thienyl, indolyl, indolinyl, isoquinolinyl,pyrazinyl, pyrazolyl, pyridazinyl, pyrimidinyl, pyrrolyl, quinolinyl,isoquinolinyl, tetrazolyl; wherein phenyl and heteroaryl are optionallysubstituted with one to three substituents independently selected fromthe group consisting of C₁₋₆alkanyloxy and hydroxy; or optionally, whenphenyl and heteroaryl are optionally substituted with two substituentsattached to adjacent carbon atoms, the two substituents together form asingle fused moiety; wherein the moiety is selected from —O(CH₂)₁₋₃O—.18. The method according to claim 1 wherein R₃ is selected from thegroup consisting of hydrogen, C₁₋₈alkanyl, C₂₋₈alkenyl, C₂₋₈alkynyl,C₁₋₈alkanyloxy(C₁₋₈)alkanyl, C₁₋₈alkanylthio(C₁₋₈)alkanyl,hydroxyC₁₋₈alkanyl, thioformyl, phenylimino(C₁₋₈)alkanyl,phenyl(C₁₋₈)alkanyl, and heteroaryl(C₁₋₈)alkanyl wherein heteroaryl isselected from the group consisting of benzo[1,3]dioxolyl, imidazolyl,furanyl, pyridinyl, thienyl, indolyl, indolinyl, isoquinolinyl,pyrazinyl, pyrazolyl, pyridazinyl, pyrimidinyl, pyrrolyl, quinolinyl,thiazolyl, isoquinolinyl, tetrazolyl; wherein phenyl and heteroaryl areoptionally substituted with one to three substituents independentlyselected from the group consisting of C₁₋₆alkanyloxy and hydroxy; oroptionally, when phenyl and heteroaryl are optionally substituted withtwo substituents attached to adjacent carbon atoms, the two substituentstogether form a single fused moiety; wherein the moiety is selected from—O(CH₂)₁₋₃O—.
 19. The method according to claim 1 wherein R₃ is selectedfrom the group consisting of hydrogen, methyl, allyl, 2-methyl-allyl,propynyl, hydroxyethyl, methylthioethyl, methoxyethyl, thioformyl,phenyliminomethyl, phenethyl, and heteroaryl(C₁₋₈)alkanyl wherein theheteroaryl is selected from the group consisting of benzo[1,3]dioxolyl,imidazolyl, furanyl, pyridinyl, thienyl, pyrimidinyl, pyrrolyl,quinolinyl, isoquinolinyl, tetrazolyl; wherein the phenyl in anyphenyl-containing substituent is optionally substituted with onehydroxyl group.
 20. The method according to claim 1 wherein R₃ isselected from the group consisting of hydrogen, methyl, methylbutenyl,propenyl, benzyl, phenethyl, and heteroaryl(C₁₋₈)alkanyl wherein theheteroaryl is selected from the group consisting of imidazolyl, furanyl,pyridinyl, thienyl, and thiazolyl.
 21. The method according to claim 1wherein R₃ is selected from the group consisting of hydrogen, methyl,3-methyl-2-butenyl, 2-propenyl, benzyl, 2-phenethyl, pyridin-2-ylmethyl,fur-3-ylmethyl, thiophene-2-ylmethyl, 1H-imidazol-2-ylmethyl, andthiazol-2-ylmethyl.
 22. The method according to claim 1 wherein R₃ ishydrogen, methyl, allyl, or heteroarylmethyl wherein heteroaryl isselected from the group consisting of benzo[1,3]dioxolyl, imidazolyl,furanyl, pyridinyl, and thienyl.
 23. The method according to claim 1wherein R₄ is one to three substituents independently selected from thegroup consisting of hydrogen; C₁₋₆alkanyl; C₁₋₆alkanyloxy;C₆₋₁₀arylamino wherein C₆₋₁₀aryl is optionally substituted with one tothree substitutents independently selected from the group consisting ofC₁₋₆alkanyl; C₁₋₆alkoxy, halogen, and hydroxy; formylamino;pyridinylamino; aminocarbonyl; C₁₋₆alkanylaminocarbonyl;C₁₋₆alkanylcarbonylamino; halogen; hydroxy; C₆₋₁₀aryl; chromanyl;chromenyl; furanyl; imidazolyl; indazolyl; indolyl; indolinyl;isoindolinyl; isoquinolinyl; isothiazolyl; isoxazolyl; naphthyridinyl;oxazolyl; pyrazinyl; pyrazolyl; pyridazinyl; pyridinyl; pyrimidinyl;pyrrolyl; quinazolinyl; quinolinyl; quinolizinyl; quinoxalinyl;tetrazolyl; thiazolyl; and thienyl.
 24. The method according to claim 1wherein R₄ is one to two substituents independently selected from thegroup consisting of hydrogen, C₁₋₄alkanyl, C₁₋₄alkanyloxy, halogen,phenyl, furanyl, imidazolyl, indazolyl, indolyl, indolinyl,isoindolinyl, isoquinolinyl, isothiazolyl, isoxazolyl, oxazolyl,pyrazinyl, pyrazolyl, pyridazinyl, pyridinyl, pyrimidinyl, pyrrolyl,quinolinyl, tetrazolyl, thiazolyl, thienyl, and hydroxy.
 25. The methodaccording to claim 1 wherein R₄ is one to two substituents independentlyselected from the group consisting of hydrogen, methyl, methoxy, bromo,fluoro, α′- or β′-phenyl, α′- or β′-pyridinyl, α′- or β′-furanyl, andhydroxy.
 26. The method according to claim 1 wherein R₄ is one to twosubstituents independently selected from the group consisting ofhydrogen, methyl, phenyl, bromo, fluoro, methoxy, aminocarbonyl, chloroand hydroxy.
 27. The method according to claim 1 wherein R₄ is hydrogen,α′-methoxy, or α′-hydroxy.
 28. The method according to claim 1 whereinR₄ is hydrogen.
 29. The method according to claim 1 wherein R₄ isα′-hydroxy.
 30. The method according to claim 1 wherein R₅ is one to twosubstituents independently selected from the group consisting ofhydrogen and halogen.
 31. The method according to claim 1 wherein R₅ ishydrogen.
 32. The method according to claim 1 wherein A is —(CH₂)₂₋₃—.33. The method according to claim 1 wherein A is —(CH₂)₂—.
 34. Themethod according to claim 1 wherein Z is O, NH, N(C₁₋₆alkanyl), N(OH),N(OC₁₋₆alkanyl), or N(phenyl).
 35. The method according to claim 1wherein Z is O, NH, or N(OH).
 36. The method according to claim 1wherein Z is O or NH.
 37. The method according to claim 1 wherein G is—C(Z)N(R₁)R₂, phenyl, or a heterocycle selected from the groupconsisting of tetrazolyl, oxadizolyl, furyl, quinolinyl, thienyl, orpyridinyl; wherein phenyl and the heterocycles of G are optionallysubstituted with one to three substituents independently selected fromthe group consisting of C₁₋₈alkanyl, C₁₋₈alkanyloxy,hydroxy(C₁₋₈)alkanyl, carboxy(C₁₋₈)alkanyl, C₁₋₈alkanylcarbonylamino,halogen, hydroxy, cyano, oxo, thioxo, amino, C₁₋₆alkanylamino,di(C₁₋₆alkanyl)amino, C₁₋₈alkanylthio, aminocarbonyl, aminothiocarbonyl,C₁₋₈alkanylaminocarbonyl, di(C₁₋₈alkanyl)aminocarbonyl, andC₁₋₆alkanyloxycarbonylamino; R₁ is C₁₋₄alkanyl, or hydrogen; R₂ ishydrogen or C₁₋₄alkanyl optionally substituted with phenyl; or R₁ and R₂taken together with the nitrogen to which they are attached form apyrrolidinyl ring optionally substituted with hydroxy; Z is NH oroxygen; R₃ is pyridinyl(C₁₋₈)alkanyl, furyl(C₁₋₈)alkanyl, C₁₋₈ alkanyl,hydrogen, C₂₋₈ alkenyl, thienyl(C₁₋₈)alkanyl, imidazolyl(C₁₋₈)alkanyl,phenyl(C₁₋₈)alkanyl, or thiazolyl(C₁₋₈)alkanyl; R₄ is hydrogen,C₁₋₆alkanyl, C₁₋₆alkanyloxy, hydroxy, halogen, aminocarbonyl, or phenyl;R₅ is hydrogen; A is CH₂CH₂; Z is O or NH; and enantiomers,diastereomers, tautomers, and pharmaceutically acceptable salts thereof.38. The method according to claim 37 wherein G is —C(Z)N(R₁)R₂;tetrazolyl; oxadiazolyl optionally substituted with oxo; furyl;quinolinyl; thienyl; phenyl optionally substituted with(C₁₋₈)alkanylcarbonylamino; or pyridinyl.
 39. The method according toclaim 38 wherein when R₁ and R₂ taken together with the nitrogen towhich they are attached form a pyrrolidinyl ring optionally substitutedwith hydroxy, Z is oxygen
 40. The method according to claim 1 wherein: Gis —C(Z)N(R₁)R₂; tetrazolyl; oxadiazolyl optionally substituted withoxo; phenyl optionally substituted with (C₁₋₈)alkanylcarbonylamino; orpyridinyl; R₁ is C₁₋₄ alkanyl, or hydrogen; R₂ is hydrogen or C₁₋₄alkanyl optionally substituted with phenyl; or R₁ and R₂ taken togetherwith the nitrogen to which they are attached form a pyrrolidinyl ringoptionally substituted with hydroxyl; Z is NH or oxygen; R₃ ispyridinyl(C₁₋₈)alkanyl, furyl(C₁₋₈)alkanyl, C₁₋₈ alkanyl, hydrogen, C₂₋₈alkenyl, thienyl(C₁₋₈)alkanyl, imidazolyl(C₁₋₈)alkanyl,phenyl(C₁₋₈)alkanyl, or thiazolyl(C₁₋₈)alkanyl; R₄ is hydrogen,α′-hydroxy, or α′-methoxy; R₅ is hydrogen; A is CH₂CH₂; Z is O or NH;and enantiomers, diastereomers, tautomers, and pharmaceuticallyacceptable salts thereof.
 41. The method according to claim 1 wherein: Gis —C(Z)N(R₁)R₂, 1H-tetrazol-4-yl, 4H-[1,2,4]-oxadiazol-5-oxo-3-yl,2-methylcarbonylaminophenyl, pyridin-3-yl or pyridin-4-yl, R₁ ishydrogen, ethyl, or methyl, R₂ is methyl, ethyl, phenethyl, or hydrogen;or R₁ and R₂ taken together with the nitrogen to which they are attachedform pyrrolidin-1-yl, 3-hydroxypyrrolidin-1-yl, or3-(S)-hydroxypyrrolidin-1-yl; Z is NH or oxygen, R₃ ispyridin-2-ylmethyl, fur-3-ylmethyl, methyl, hydrogen,3-methyl-2-butenyl, thiophene-2-ylmethyl, 2-propenyl,1H-imidazol-2-ylmethyl, 2-phenethyl, thiazol-2-ylmethyl, benzyl, R₄ ishydrogen, α′-methoxy, or α′-hydroxy, R₅ is hydrogen A is CH₂CH₂; Z is Oor NH; and enantiomers, diastereomers, tautomers, and pharmaceuticallyacceptable salts thereof.
 42. A method of providing analgesia comprisingadministering to a patient a compound of Formula (I):

wherein: G is independently selected from —C(Z)N(R₁)R₂, phenyl, or aheterocycle selected from the group consisting of imidazolyl, triazolyl,tetrazolyl, oxadiazolyl, thiadiazolyl, oxathiadiazolyl, imidazolinyl,tetrahydropyrimidinyl, thienyl, pyrazolyl, pyrimidinyl, triazinyl,isothiazolyl, isoxazolyl, oxazolyl, isoxadiazolyl, and pyridinyl;wherein phenyl and the heterocycles of G are optionally substituted withone to three substituents independently selected from the groupconsisting of C₁₋₈alkanyl, C₁₋₈alkanyloxy, hydroxy(C₁₋₈)alkanyl,carboxy(C₁₋₈)alkanyl, C₁₋₈alkanylcarbonylamino, halogen, hydroxy, cyano,oxo, thioxo, amino, C₁₋₆alkanylamino, di(C₁₋₆alkanyl)amino,C₁₋₈alkanylthio, aminocarbonyl, aminothiocarbonyl,C₁₋₈alkanylaminocarbonyl, di(C₁₋₈alkanyl)aminocarbonyl, andC₁₋₆alkanyloxycarbonylamino; provided that when G is pyridin-3-yl orthien-3-yl and R³ is hydrogen, R⁴ is other than hydrogen; R₁ is hydrogenor C₁₋₄alkanyl; R₂ is selected from the group consisting of hydrogen;C₁₋₄alkanyl; phenyl; and C₁₋₆cycloalkanyl; wherein C₁₋₄alkanyl isoptionally substituted with one to three substituents independentlyselected from the group consisting of phenyl, amino, C₁₋₆alkanylamino,di(C₁₋₆alkanyl)amino, C₁₋₄alkanyloxy, hydroxy, fluoro, chloro, cyano,aminocarbonyl, C₁₋₈alkanylaminocarbonyl, di(C₁₋₈alkanyl)aminocarbonyl,and phenoxy; and wherein any phenyl-containing substituent of R₂ andC₁₋₆cycloalkanyl substituents of R₂ are optionally substituted with oneto three substituents independently selected from the group consistingof C₁₋₈alkanyl, C₁₋₈alkanyloxy, trifluoromethyl, phenyl, fluoro,hydroxy, C₁₋₈alkanylthio, C₁₋₈alkanylsulfonyl, andC₁₋₈alkanylsulfonylamino; or R₁ and R₂ taken together with the nitrogento which they are attached form a 5-7 membered heterocycloalkyl whereinsaid heterocycloalkyl is optionally substituted with one to threesubstituents independently selected from the group consisting ofC₁₋₈alkanyl, hydroxy(C₁₋₈)alkanyl, and hydroxy; R₃ is selected from thegroup consisting of hydrogen, C₁₋₈alkanyl, C₂₋₈alkenyl, C₂₋₈alkynyl,C₁₋₈alkanyloxy(C₁₋₈)alkanyl, C₁₋₈alkanylthio (C₁₋₈)alkanyl,hydroxyC₁₋₈alkanyl, thioformyl, phenylimino(C₁₋₈)alkanyl,phenyl(C₁₋₈)alkanyl, and heteroaryl(C₁₋₈)alkanyl wherein heteroaryl isselected from the group consisting of benzo[1,3]dioxolyl, imidazolyl,furanyl, pyridinyl, thienyl, indolyl, indolinyl, isoquinolinyl,pyrazinyl, pyrazolyl, pyridazinyl, pyrimidinyl, pyrrolyl, quinolinyl,isoquinolinyl, tetrazolyl; wherein phenyl and heteroaryl are optionallysubstituted with one to three substituents independently selected fromthe group consisting of C₁₋₆alkanyloxy and hydroxy; or optionally, whenphenyl and heteroaryl are optionally substituted with two substituentsattached to adjacent carbon atoms, the two substituents together form asingle fused moiety; wherein the moiety is selected from —O(CH₂)₁₋₃O—;R₄ is one to three substituents independently selected from the groupconsisting of hydrogen; C₁₋₆alkanyl; C₁₋₆alkanyloxy; C₆₋₁₀arylaminowherein C₆₋₁₀aryl is optionally substituted with one to threesubstitutents independently selected from the group consisting ofC₁₋₆alkanyl; C₁₋₆alkoxy, halogen, and hydroxy; formylamino;pyridinylamino; aminocarbonyl; C₁₋₆alkanylaminocarbonyl;C₁₋₆alkanylcarbonylamino; halogen; hydroxy; C₆₋₁₀aryl; chromanyl;chromenyl; furanyl; imidazolyl; indazolyl; indolyl; indolinyl;isoindolinyl; isoquinolinyl; isothiazolyl; isoxazolyl; naphthyridinyl;oxazolyl; pyrazinyl; pyrazolyl; pyridazinyl; pyridinyl; pyrimidinyl;pyrrolyl; quinazolinyl; quinolinyl; quinolizinyl; quinoxalinyl;tetrazolyl; thiazolyl; and thienyl; R₅ is one to two substituentsindependently selected from the group consisting of hydrogen andhalogen; A is CH₂CH₂; Y is O; Z is O, NH, N(C₁₋₆alkanyl), N(OH),N(OC₁₋₆alkanyl), or N(phenyl); and enantiomers, diastereomers,tautomers, and pharmaceutically acceptable salts thereof.
 43. A methodof providing analgesia comprising administering a compound of Formula(I):

wherein: G is selected from —C(Z)N(R₁)R₂, phenyl, or a heterocycleselected from the group consisting of imidazolyl, tetrazolyl,oxadiazolyl, thiadiazolyl, oxathiadiazolyl, imidazolinyl, thienyl,pyrazolyl, pyrimidinyl, triazinyl, isothiazolyl, isoxazolyl, oxazolyl,isoxadiazolyl, and pyridinyl; wherein phenyl and the heterocycles of Gare optionally substituted with one to three substituents independentlyselected from the group consisting of C₁₋₄alkanyl, C₁₋₄alkanyloxy,hydroxy(C₁₋₄)alkanyl, carboxy(C₁₋₄alkanyl, C₁₋₄alkanylcarbonylamino,hydroxy, cyano, oxo, thioxo, amino, C₁₋₆alkanylamino,di(C₁₋₆alkanyl)amino, C₁₋₈alkanylthio, aminocarbonyl, aminothiocarbonyl,C₁₋₈alkanylaminocarbonyl, and di(C₁₋₈alkanyl)aminocarbonyl; R₁ isselected from the group consisting of hydrogen, methyl, ethyl, andpropyl; R₂ is selected from the group consisting of hydrogen,C₁₋₄alkanyl, phenyl, and C₁₋₆cycloalkanyl; wherein C₁₋₄alkanyl isoptionally substituted with one to three substituents independentlyselected from the group consisting of phenyl, C₁₋₄alkanyloxy, hydroxy,fluoro, aminocarbonyl, C₁₋₈alkanylaminocarbonyl,di(C₁₋₈alkanyl)aminocarbonyl, and phenoxy; and wherein anyphenyl-containing substituent of R₂ is optionally substituted with oneto three substituents independently selected from the group consistingof C₁₋₆alkanyl, C₁₋₆alkanyloxy, fluoro, hydroxy, and C₁₋₆alkanylthio; orR₁ and R₂ taken together with the nitrogen to which they are attachedform pyrrolidinyl or piperidinyl ring wherein said pyrrolidinyl orpiperidinyl is optionally substituted with a substituent selected fromthe group consisting of C₁₋₃alkanyl and hydroxy; R₃ is selected from thegroup consisting of hydrogen, methyl, allyl, 2-methyl-allyl, propynyl,hydroxyethyl, methylthioethyl, methoxyethyl, thioformyl,phenyliminomethyl, phenethyl, and heteroaryl(C₁₋₈)alkanyl wherein theheteroaryl is selected from the group consisting of benzo[1,3]dioxolyl,imidazolyl, furanyl, pyridinyl, thienyl, pyrimidinyl, pyrrolyl,quinolinyl, isoquinolinyl, tetrazolyl; wherein the phenyl in anyphenyl-containing substituent is optionally substituted with onehydroxyl group; R₄ is one to two substituents independently selectedfrom the group consisting of hydrogen, C₁₋₄alkanyl, C₁₋₄alkanyloxy,halogen, phenyl, furanyl, imidazolyl, indazolyl, indolyl, indolinyl,isoindolinyl, isoquinolinyl, isothiazolyl, isoxazolyl, oxazolyl,pyrazinyl, pyrazolyl, pyridazinyl, pyridinyl, pyrimidinyl, pyrrolyl,quinolinyl, tetrazolyl, thiazolyl, thienyl, and hydroxy; R₅ is hydrogen;A is CH₂CH₂; Y is O; Z is O, NH, or N(OH); and enantiomers,diastereomers, tautomers, and pharmaceutically acceptable salts thereof.44. The method according to claim 43 wherein G is —C(Z)N(R₁)R₂, phenyl,or a heterocycle selected from the group consisting of imidazolyl,tetrazolyl, oxadiazolyl, thiadiazolyl, oxathiadiazolyl, thienyl,isothiazolyl, isoxazolyl, isoxadiazolyl, and pyridinyl; wherein phenyland the heterocycles of G are optionally substituted with one to threesubstituents independently selected from the group consisting ofC₁₋₄alkanyl, C₁₋₄alkanyloxy, hydroxy(C₁₋₄)alkanyl,C₁₋₄alkanylcarbonylamino, hydroxy, cyano, oxo, thioxo, andaminocarbonyl.
 44. The method according to claim 43 wherein G is—C(Z)N(R₁)R₂, 2-methylcarbonylaminophenyl, 2-aminocarbonyl-phenyl,1H-tetrazol-4-yl, 2-methyl-tetrazol-5-yl,4H-[1,2,4]-oxadiazol-5-oxo-3-yl, 4H-[1,2,4]-oxadiazol-5-thioxo-3-yl,4H-[1,2,4]thiadiazol-5-oxo-3-yl, [1,2,3,5]oxathiadiazol-2-oxo-4-yl, orpyridin-3-yl.
 45. The method according to claim 43 wherein G is—C(Z)N(R₁)R₂, 1H-tetrazol-4-yl, 4H-[1,2,4]-oxadiazol-5-oxo-3-yl,2-methylcarbonylaminophenyl, pyridin-3-yl or pyridin-4-yl.
 46. Themethod according to claim 43 wherein R₂ is selected from the groupconsisting of hydrogen, C₁₋₄alkanyl and phenyl; wherein C₁₋₄alkanyl isoptionally substituted with one to three substituents independentlyselected from the group consisting of phenyl, C₁₋₄alkanyloxy, hydroxy,fluoro, and phenoxy; and wherein any phenyl-containing substituent isoptionally substituted with one to three substituents independentlyselected from the group consisting of C₁₋₆alkanyl, C₁₋₆alkanyloxy,fluoro, and hydroxy; or R₁ and R₂ taken together with the nitrogen towhich they are attached form a pyrrolidinyl or piperidinyl ring whereinsaid pyrrolidinyl or piperidinyl is optionally substituted with asubstituent selected from C₁₋₃alkanyl or hydroxy; and R₃ is asubstituent selected from the group consisting ofbenzo[1,3]dioxol-5-ylmethyl, carbamimidoyl, 1-H-imidazol-4-ylmethyl,phenyliminomethyl, 1-prop-2-ynyl, thioformyl, 2-hydroxyphenyl-methyl,hydroxy-ethyl, methoxy-ethyl, 2-methyl-allyl, 2-methyl-but-2-enyl,allyl, furan-3-ylmethyl, H, Me, methylthioethyl, phenethyl, pyridin-2-ylmethyl, and thiophen-2-yl methyl.
 47. The method according to claim 43wherein R₁ is hydrogen, ethyl, or methyl; R₂ is methyl, ethyl,phenethyl, or hydrogen; or R₁ and R₂ taken together with the nitrogen towhich they are attached form pyrrolidin-1-yl, 3-hydroxypyrrolidin-1-yl,or 3-(S)-hydroxypyrrolidin-1-yl.
 48. A method of providing analgesiacomprising administering to a patient a compound of Formula (I):

wherein: G is selected from —C(Z)N(R₁)R₂, 2-methylcarbonylaminophenyl,2-aminocarbonyl-phenyl, 1H-tetrazol-4-yl, 2-methyl-tetrazol-5-yl, 4H-[1,2,4]-oxadiazol-5-oxo-3-yl, 4H-[1,2,4]-oxadiazol-5-thioxo-3-yl, 4H-[1,2,4]thiadiazol-5-oxo-3-yl, [1,2,3,5]oxathiadiazol-2-oxo-4-yl, orpyridin-3-yl; R₁is hydrogen, methyl, or ethyl; R₂ is selected from thegroup consisting of hydrogen, C₁₋₄alkanyl and phenyl; whereinC₁₋₄alkanyl is optionally substituted with one to three substituentsindependently selected from the group consisting of phenyl,C₁₋₄alkanyloxy, hydroxy, fluoro, and phenoxy; and wherein anyphenyl-containing substituent of R₂ is optionally substituted with oneto three substituents independently selected from the group consistingof C₁₋₆alkanyl, C₁₋₆alkanyloxy, fluoro, and hydroxy; or R₁ and R₂ takentogether with the nitrogen to which they are attached form apyrrolidinyl or piperidinyl ring wherein said pyrrolidinyl orpiperidinyl is optionally substituted with a substituent selected fromC₁₋₃alkanyl or hydroxy; R₃ is selected from the group consisting ofhydrogen, methyl, allyl, 2-methyl-allyl, propynyl, hydroxyethyl,methylthioethyl, methoxyethyl, thioformyl, phenyliminomethyl, phenethyl,and heteroaryl(C₁₋₈)alkanyl wherein the heteroaryl is selected from thegroup consisting of benzo[1,3]dioxolyl, imidazolyl, furanyl, pyridinyl,thienyl, pyrimidinyl, pyrrolyl, quinolinyl, isoquinolinyl, tetrazolyl;wherein the phenyl in any phenyl-containing substituent is optionallysubstituted with one hydroxyl group; R₄ is one to three substituentsindependently selected from the group consisting of hydrogen,C₁₋₄alkanyl, C₁₋₄alkanyloxy, halogen, phenyl, furanyl, imidazolyl,indazolyl, indolyl, indolinyl, isoindolinyl, isoquinolinyl,isothiazolyl, isoxazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridazinyl,pyridinyl, pyrimidinyl, pyrrolyl, quinolinyl, tetrazolyl, thiazolyl,thienyl, and hydroxy; R₅ is hydrogen; A is CH₂CH₂; Y is O; Z is O or NH;and enantiomers, diastereomers, tautomers, and pharmaceuticallyacceptable salts thereof.
 49. The method according to claim 48 whereinR₂ is a substituent selected from the group consisting of hydrogen,C₁₋₄alkanyl and phenyl; wherein C₁₋₄alkanyl is optionally substitutedwith one to three substituents independently selected from the groupconsisting of phenyl, C₁₋₄alkanyloxy, hydroxy, and 2,6-dimethyl-phenoxy;and wherein any phenyl-containing substituent of R₂ is optionallysubstituted with one to three substituents independently selected fromthe group consisting of C₁₋₆alkanyl, C₁₋₆alkanyloxy, fluoro, andhydroxy; or R₁ and R₂ taken together with the nitrogen to which they areattached form a pyrrolidinyl or piperidinyl ring wherein saidpyrrolidinyl or piperidinyl is optionally substituted with a substituentselected from C₁₋₃alkanyl or hydroxy.
 50. The method according to claim48 wherein R₃ is a substituent selected from the group consisting ofbenzo[1,3]dioxol-5-ylmethyl, carbamimidoyl, 1-H-imidazol-4-ylmethyl,phenyliminomethyl, 1-prop-2-ynyl, thioformyl, 2-hydroxyphenyl-methyl,hydroxy-ethyl, methoxy-ethyl, 2-methyl-allyl, 2-methyl-but-2-enyl,allyl, furan-3-ylmethyl, H, Me, methylthioethyl, phenethyl, pyridin-2-ylmethyl, and thiophen-2-ylmethyl; and R₄ is one to two substituentsindependently selected from the group consisting of hydrogen,C₁₋₄alkanyl, C₁₋₄alkanyloxy, halogen, phenyl, furanyl, imidazolyl,indazolyl, indolyl, indolinyl, isoindolinyl, isoquinolinyl,isothiazolyl, isoxazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridazinyl,pyridinyl, pyrimidinyl, pyrrolyl, quinolinyl, tetrazolyl, thiazolyl,thienyl, and hydroxy.
 51. The method according to claim 48 wherein R₃ isa substituent selected from the group consisting ofbenzo[1,3]dioxol-5-ylmethyl, carbamimidoyl, 1-H-imidazol-4-yl methyl,phenyliminomethyl, 1-prop-2-ynyl, thioformyl, 2-hydroxyphenyl-methyl,hydroxyethyl, methoxyethyl, allyl, furan-3-yl methyl, H, Me,methylthioethyl, and phenethyl; R₄ is one to two substituentsindependently selected from the group consisting of hydrogen, methyl,methoxy, bromo, fluoro, α′- or β′-phenyl, α′- or β′-pyridinyl, α′- orβ′-furanyl, and hydroxy.
 52. The method according to claim 48 wherein R₃is a substituent selected from the group consisting of H,benzo[1,3]dioxol-5-ylmethyl, 1-H-imidazol-4-yl methyl, furan-3-ylmethyl,pyridin-2-ylmethyl, and phenyliminomethyl; and R₄ is a substituentindependently selected from the group consisting of hydrogen, methyl,methoxy, bromo, fluoro, α′- or β′-phenyl, α′- or β′-pyridinyl, α′- orβ′-furanyl, and hydroxy.
 53. A method of providing analgesia comprisingadministering to a patient a compound of Formula (I):

selected from the group consisting of: a compound of Formula (I) whereinG is N,N-diethylaminocarbonyl; R³ is 1H-imidazol-2-yl-methyl; R⁴ isα′-hydroxy; R⁵ is H; Y is O; and A is —CH₂CH₂—; a compound of Formula(I) wherein G is N,N-diethylaminocarbonyl; R³ is furan-3-yl-methyl; R⁴is α′-hydroxy; R⁵ is H; Y is O; and A is —CH₂CH₂—; a compound of Formula(I) wherein G is N,N-diethylaminocarbonyl; R³ is H; R⁴ is α′-hydroxy; R⁵is H; Y is O; and A is —CH₂CH₂—; a compound of Formula (I) wherein G isN,N-diethylaminocarbonyl; R³ is H; R⁴ is α′-methoxy; R⁵ is H; Y is O;and A is —CH₂CH₂—; a compound of Formula (I) wherein G isN,N-diethylaminocarbonyl; R³ is pyridin-2-yl-methyl; R⁴ is H; R⁵ is H; Yis O; A is —CH₂CH₂—; a compound of Formula (I) wherein G isN,N-diethylaminocarbonyl; R³ is furan-3-yl-methyl; R⁴ is H; R⁵ is H; Yis O; and A is —CH₂CH₂—; a compound of Formula (I) wherein G isN,N-diethylaminocarbonyl; R³ is thien-2-yl-methyl; R⁴ is H; R⁵ is H; Yis O; and A is —CH₂CH₂—; a compound of Formula (I) wherein G isN,N-diethylaminocarbonyl; R³ is benzyl; R⁴ is H; R⁵ is H; Y is O; and Ais —CH₂CH₂—; a compound of Formula (I) wherein G is pyridin-3-yl; R³ isfuran-3-y1 methyl; R⁴ is H; R⁵ is H; Y is O; and A is —CH₂CH₂—; acompound of Formula (I) wherein G is N,N-diethylaminocarbonyl; R³ isfuran-2-yl methyl; R⁴ is H; R⁵ is H; Y is O; and A is —CH₂CH₂—; acompound of Formula (I) wherein G is N,N-diethylaminocarbonyl; R³ is H;R⁴ is α′-methyl; R⁵ is H; Y is O; and A is —CH₂CH₂—; a compound ofFormula (I) wherein G is N,N-diethylaminocarbonyl; R³ is H; R⁴ isα′-phenyl; R⁵ is H; Y is O; and A is —CH₂CH₂—; a compound of Formula (I)wherein G is N,N-diethylaminocarbonyl; R³ is H; R⁴ is H; R⁵ is H; Y isO; and A is —CH₂CH₂—; a compound of Formula (I) wherein G isN,N-diethylaminocarbonyl; R³ is H; R⁴ is H; R⁵ is H; Y is O; and A is—CH₂CH₂—; a compound of Formula (I) wherein G isN,N-diethylaminocarbonyl; R³ is H; R⁴ is β″-bromo; R⁵ is H; Y is O; andA is —CH₂CH₂—; a compound of Formula (I) wherein G isN,N-diethylaminocarbonyl; R³ is H; R⁴ is H; R⁵ is H; Y is O; and A is—CH₂CH₂—; a compound of Formula (I) wherein G isN,N-diethylaminocarbonyl; R³ is H; R⁴ is α′-chloro; R⁵ is H; Y is O; andA is —CH₂CH₂—; a compound of Formula (I) wherein G isN,N-diethylaminocarbonyl; R³ is H; R⁴ is α′-fluoro; R⁵ is H; Y is O; andA is —CH₂CH₂—; a compound of Formula (I) wherein G is2-methylcarbonylamino-phenyl; R³ is H; R⁴ is H; R⁵ is H; Y is O; and Ais —CH₂CH₂—; a compound of Formula (I) wherein G is pyrrolidin-1-yl; R³is H; R⁴ is H; R⁵ is H; Y is O; and A is —CH₂CH₂—; a compound of Formula(I) wherein G is N,N-diethylaminocarbonyl; R³ is furan-3-yl-methyl; R⁴is H; R⁵ is H; Y is O; and A is —CH₂CH₂—; and a compound of Formula (I)wherein G is N,N-diethylaminocarbonyl; R³ is furan-3-yl-methyl; R⁴ is H;R⁵ is H; Y is O; and A is —CH₂CH₂—.
 54. A method according to claim 1wherein the compound is:10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide; (3-Hydroxy-pyrrolidin-1-yl)-[10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-yl]-methanone;10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3 -carboxylicacid methyl-phenethyl-amide;Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine;Endo-10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine;Endo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine;Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-N,N-diethyl-10H-phenoxazine-3-carboxamidine;Endo-N,N-Diethyl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxamidine;Endo-N,N-Diethyl-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxamidine;Endo-3-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-yl]-4H-[1,2,4]oxadiazol-5-one;endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic acidamide; Endo-3-[10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-yl]-4H-[1,2,4]oxadiazol-5-one;Endo-3-[10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-yl]-4H-[1,2,4]oxadiazol-5-one;10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide;10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-10H-phenoxazine-3-carboxylicacid diethylamide;6-Methoxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide;6-Hydroxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide;6-Methoxy-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide;10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine;N,N-Diethyl-10-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxamidine;3-[10-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-yl]-4H-[1,2,4]oxadiazol-5-one;10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenothiazine;N-{2-[10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine-3-yl]-phenyl}-acetamide;10-[8-(3-Methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-3-pyridin-3-yl-10H-phenothiazine;3-Pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine;10-[8-(3-Methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-3-pyridin-4-yl-10H-phenothiazine;3-Pyridin-4-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine;or3-Pyridin-4-yl-10-(8-thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenothiazine.55. A method according to claim 1 wherein the compound is:Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine;Endo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine;Endo-3-Pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine;Endo-10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine;Endo-3-Pyridin-3-yl-10-(8-thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine;Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine;Endo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine;Endo-3-Pyridin-4-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl-10H-phenoxazine;Endo-10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10-phenoxazine;Endo-3-Pyridin-4-yl-10-(8-thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine;Exo-3-(3-Pyridin-3-yl-phenoxazine-10-yl)-8-aza-bicyclo[3.2.1]octane-8-carboxylicacid tert-butyl ester;Exo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine;Exo-3-Pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine;Exo-10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine;Exo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine;Exo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine;Exo-3-Pyridin-4-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine;Exo-10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine;Exo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine;or Exo-3-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazin-3-yl]-4H-[1,2,4]oxadiazol-5-one;
 56. A method according to claim 1wherein the compound is:Endo-10-(8-Thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide;Endo-10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide;Endo-10-(8-Thiazol-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide;Endo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide;Endo-10-(8-Pyridin-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide;Endo-10-[8-(3-Methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenoxazine-3-carboxylicacid diethylamide;Endo-10-[8-(1H-Imidazol-2-ylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenoxazine-3-carboxylicacid diethylamide;Endo-10-(8-Benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide;Exo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylic aciddiethylamide;Exo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide;Exo-10-(8-Pyridin-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide;Exo-10-(8-Thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide;Exo-10-[8-(3-Methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenoxazine-3-carboxylicacid diethylamide;Exo-10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide;Exo-10-(8-Benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide; orExo-10-(8-Thiazol-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide.
 57. A method according to claim 1 that is:Exo-10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide;Exo-10-[8-(1H-Imidazol-2-ylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenoxazine-3-carboxylicacid diethylamide;Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-7-pyridin-3-yl-10H-phenoxazine-4-ol;Endo-7-Pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-4-ol;Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-3-pyridin-3-yl-10H-phenoxazine;Endo-6-Methoxy-3-pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine;Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-7-pyridin-4-yl-10H-phenoxazin-4-ol;Endo-7-Pyridin-4-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-4-ol;Endo-10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-7-pyridin-4-yl-10H-phenoxazine-4-ol;Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-3-pyridin-4-yl-10H-phenoxazine;Endo-6-Methoxy-3-pyridin-4-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine;Endo-6-Methoxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-4-yl-10H-phenoxazine;Endo-N-{2-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-yl]-phenyl}-acetamide;Endo-N-{2-[10-(8-Phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-yl]-phenyl}-acetamide;Endo-N-{2-[10-(8-Thiophen-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-yl]-phenyl}-acetamide;Endo-N-{2-[10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-yl]-phenyl}-acetamide;Exo-N-{2-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-yl]-phenyl}-acetamide;Endo-N-{2-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-hydroxy-10H-phenoxazine-3-yl]-phenyl}-acetamide;orEndo-N-{2-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-methoxy-10H-phenoxazine-3-yl]-phenyl}-acetamide.58. A method according to claim 1 wherein the compound is:Endo-10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide;Endo-10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-(1H-tetrazol-5-yl)-10H-phenoxazine;Endo-3-[10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-yl]-4H-[1,2,4]oxadiazol-5-one;Endo-10-[8-(1H-Imidazol-2-ylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenoxazine-3-carboxylicacid diethylamide;Endo-10-[8-(3-Methyl-but-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-10H-phenoxazine-3-carboxylicacid diethylamide;Endo-7-Pyridin-3-yl-10-(8-pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-4-ol;Endo-N-{2-[10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-6-hydroxy-10H-phenoxazine-3-yl]-phenyl}-acetamide;Endo-10-(8-Benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide;6-Hydroxy-10-(8-phenethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide;Endo-10-(8-Pyridin-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamide;Exo-10-(8-Pyridin-2-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-10H-phenoxazine-3-carboxylicacid diethylamideEndo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-7-pyridin-4-yl-10H-phenoxazine-4-ol;Endo-10-(8-Aza-bicyclo[3.2.1]oct-3-yl)-7-pyridin-3-yl-10H-phenoxazine-4-ol;orEndo-10-(8-Furan-3-ylmethyl-8-aza-bicyclo[3.2.1]oct-3-yl)-3-pyridin-3-yl-10H-phenoxazine.59. A method of providing analgesia comprising administering to apatient a composition comprising the dextrorotatory enantiomer of acompound according to claim 1 wherein said composition is substantiallyfree from the levorotatory isomer of said compound.
 60. A method ofproviding analgesia comprising administering to a patient a compositioncomprising the levororotatory enantiomer of a compound according toclaim 1 wherein said composition is substantially free from thedextrorotatory isomer of said compound.
 61. A method of providinganalgesia comprising administering to a patient a composition comprisingthe exo isomer of a compound according to claim 1 wherein saidcomposition is substantially free from the endo isomer of said compound.62. A method of providing analgesia comprising administering to apatient a composition comprising the endo isomer of a compound accordingto claim 1 wherein said composition is substantially free from the exoisomer of said compound.
 63. A method of providing analgesia comprisingadministering to a patient a pharmaceutical composition comprising acompound, salt or solvate according to any of claims 1 admixed with apharmaceutically acceptable carrier, excipient or diluent.
 64. A methodof providing analgesia comprising administering to a patient aveterinary composition comprising a compound, salt or solvate accordingto claim 1 admixed with a veterinarily acceptable carrier, excipient ordiluent.
 65. A method of providing analgesia comprising administering toa patient a pharmaceutical composition comprising a compound, salt orsolvate according to claim 42 admixed with a pharmaceutically acceptablecarrier, excipient or diluent.
 66. A method of providing analgesiacomprising administering to a patient a veterinary compositioncomprising a compound, salt or solvate according to claim 42 admixedwith a veterinarily acceptable carrier, excipient or diluent.
 67. Amethod of providing analgesia comprising administering to a patient apharmaceutical composition comprising a compound, salt or solvateaccording to claim 43 admixed with a pharmaceutically acceptablecarrier, excipient or diluent.
 68. A method of providing analgesiacomprising administering to a patient a veterinary compositioncomprising a compound, salt or solvate according to claim 43 admixedwith a veterinarily acceptable carrier, excipient or diluent.
 69. Amethod of providing analgesia comprising administering to a patient apharmaceutical composition comprising a compound, salt or solvateaccording to claim 48 admixed with a pharmaceutically acceptablecarrier, excipient or diluent.
 70. A method of providing analgesiacomprising administering to a patient a veterinary compositioncomprising a compound, salt or solvate according to claim 48 admixedwith a veterinarily acceptable carrier, excipient or diluent.
 71. Amethod of providing analgesia comprising administering to a patient apharmaceutical composition comprising a compound, salt or solvateaccording to claim 53 admixed with a pharmaceutically acceptablecarrier, excipient or diluent.
 72. A method of providing analgesiacomprising administering to a patient a veterinary compositioncomprising a compound, salt or solvate according to claim 53 admixedwith a veterinarily acceptable carrier, excipient or diluent.
 73. Amethod of providing analgesia comprising administering to a patient apharmaceutical composition comprising a compound, salt or solvateaccording to claim 54 admixed with a pharmaceutically acceptablecarrier, excipient or diluent.
 74. A method of providing analgesiacomprising administering to a patient a veterinary compositioncomprising a compound, salt or solvate according to claim 54 admixedwith a veterinarily acceptable carrier, excipient or diluent.
 75. Amethod of providing analgesia comprising administering to a patient apharmaceutical composition comprising a compound, salt or solvateaccording to claim 55 admixed with a pharmaceutically acceptablecarrier, excipient or diluent.
 76. A method of providing analgesiacomprising administering to a patient veterinary composition comprisinga compound, salt or solvate according to claim 55 admixed with aveterinarily acceptable carrier, excipient or diluent.
 77. A method ofproviding analgesia comprising administering to a patient apharmaceutical composition comprising a compound, salt or solvateaccording to claim 59 admixed with a pharmaceutically acceptablecarrier, excipient or diluent.
 78. A method of providing analgesiacomprising administering to a patient a veterinary compositioncomprising a compound, salt or solvate according to claim 59 admixedwith a veterinarily acceptable carrier, excipient or diluent.
 79. Amethod of providing analgesia comprising administering to a patient apharmaceutical composition comprising a compound, salt or solvateaccording to claim 60 admixed with a pharmaceutically acceptablecarrier, excipient or diluent.
 80. A method of providing analgesiacomprising administering to a patient a veterinary compositioncomprising a compound, salt or solvate according to claim 60 admixedwith a veterinarily acceptable carrier, excipient or diluent.
 81. Amethod of providing analgesia comprising administering to a patient apharmaceutical composition comprising a compound, salt or solvateaccording to claim 61 admixed with a pharmaceutically acceptablecarrier, excipient or diluent.
 82. A method of providing analgesiacomprising administering to a patient a veterinary compositioncomprising a compound, salt or solvate according to claim 61 admixedwith a veterinarily acceptable carrier, excipient or diluent.
 83. Amethod of providing analgesia comprising administering to a patient apharmaceutical composition comprising a compound, salt or solvateaccording to claim 62 admixed with a pharmaceutically acceptablecarrier, excipient or diluent.
 84. A method of providing analgesiacomprising administering to a patient a veterinary compositioncomprising a compound, salt or solvate according to claim 62 admixedwith a veterinarily acceptable carrier, excipient or diluent.